Walter Noordzij
dr.
In my profession as a nuclear medicine physician, I’m involved in both clinical and scientific applications of nuclear medicine and radiology modalities. My main interests include haematology, general oncology, radio-immunotherapy, and especially the implementation of new therapeutic strategies. Currently, I have a special interest in imaging post-transplant lymphoproliferative disease, as well as radio-immunotherapy in chemotherapy refractory (non)-Hodgkin’s lymphoma.
Scan speed reduction in post-therapy [177Lu]LuPSMA SPECT/CT: How fast can we go without afecting accuracy of dosimetry calculations?
Aim/Introduction: Accurate dose estimation in [177Lu]LuPSMA therapy is crucial for organs at risk such as the kidneys. However, the current method involves lengthy scans, causingdiscomfort for patients with bone metastases common in prostate cancer, fnancial pressure and image quality problems due to the motion. Our research aims to optimise this process byinvestigating acceptable scan reduction while maintaining the accuracy of the calculate dose to organs at risk. Materials and Methods: A total of 11 post-therapy imaging sequences from patients undergoing [177Lu]Lu-PSMA therapy were selected. For each, two post-therapy...
Clinical Performance Comparison of a Long Versus a Short Axial Field-of-View PET/CT Using EARL-Compliant Reconstructions
Published in: Molecular Imaging and Biology
Access to document
10.1007/s11307-024-01939-5
document
PURPOSE: To ensure comparable PET/CT image quality between or within centres, clinical inter-system performance comparisons following European Association of Nuclear Medicine Research Ltd. (EARL) guidelines is required. In this work the performance of the long axial field-of-view Biograph Vision Quadra is compared to its predecessor, the short axial field-of-view Biograph Vision. PROCEDURES: To this aim, patients with suspected tumour lesions received a single weight-based (3 MBq/kg) 2-deoxy-2-[ 18F]fluoro-D-glucose injection and underwent routine clinical ( ∼ 15 min) scans on the Vision and 3-min scans on the Quadra in...
Ultrashort Oncologic Whole-Body [18F]FDG Patlak Imaging Using LAFOV PET.
Published in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Access to document
10.2967/jnumed.124.267784
document
Methods to shorten [ 18F]FDG Patlak PET imaging procedures ranging from 65-90 to 20-30 min after injection, using a population-averaged input function (PIF) scaled to patient-specific image-derived input function (IDIF) values, were recently evaluated. The aim of the present study was to explore the feasibility of ultrashort 10-min [ 18F]FDG Patlak imaging at 55-65 min after injection using a PIF combined with direct Patlak reconstructions to provide reliable quantitative accuracy of lung tumor uptake, compared with a full-duration 65-min acquisition using an IDIF. Methods: Patients underwent a 65-min dynamic PET...
[15O]H2O PET: Potential or Essential for Molecular Imaging?
Published in: Seminars in Nuclear Medicine
Access to document
10.1053/j.semnuclmed.2023.08.002
document
Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a wide range of diseases that are related to perfusion and oxygenation. Although water PET has a long history, its true potential has not made it into regular clinical practice. The article highlights the potential of water PET in molecular imaging and suggests its prospective role in becoming an essential tool for the 21st century precision medicine in different...
Riemer H J A Slart, T Samara Martinez-Lucio, Hendrikus H Boersma, Ronald H Borra, Bart Cornelissen, Rudi A J O Dierckx, Magdalena Dobrolinska, Janine Doorduin, Paola A Erba, Andor W J M Glaudemans, Bruno Lima Giacobbo, Gert Luurtsema, Walter Noordzij, Joyce van Sluis, Charalampos Tsoumpas, Adriaan A Lammertsma
Impact of patient motion on parametric PET imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Access to document
10.1007/s00259-024-06599-9
document
Alessia Artesani, Joyce van Sluis, Johannes H van Snick, Laura Providência, Walter Noordzij, Charalampos Tsoumpas