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Arjan Diepstra
dr.

As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.

Superior survival in diffuse large B cell lymphoma of the bone with immune rich tumor microenvironment
Published in: Blood cancer journal
Access to document 10.1038/s41408-025-01291-z document
With tumor genomic and gene-expression profiling (GEP), this study investigated the immune-molecular signatures of a unique cohort of diffuse large B-cell lymphoma of the bone (bone-DLBCL), including primary bone (PB-DLBCL, n = 52) and polyostotic-DLBCL (n = 20), in comparison to nodal DLBCLs with germinal center B-cell (GCB) phenotype (nodal-DLBCL-GCB, n = 34). PB-DLBCL and polyostotic-DLBCL shared similar genomic profiles and transcriptomic signatures, justifying their collective analysis as bone-DLBCL. Differential incidences of EZH2, HIST1H1E, and MYC aberrations (p < 0.05) confirmed the distinct oncogenic evolution between bone-DLBCL and...
Ruben A.L. de Groen, Fleur A. de Groot, Stefan Böhringer, Esther J. Kret, Lorraine M. de Haan, Troy Noordenbos, Susan Blommers, Romée E.W. Jansen, Tom van Wezel, Ronald van Eijk, Richard Raghoo, Dina Ruano, Liane te Boome, Valeska Terpstra, Henriette Levenga, Els Ahsmann, Eduardus F.M. Posthuma, Isabelle Focke-Snieders, Lizan Hardi, Wietske C.E. den HartogAnke van den Berg, Pim Mutsaers, King Lam, Marjolein W.M. van der Poel, Myrurgia Abdul Hamid, F. J.Sherida H. Woei-A-Jin, Ann Janssens, Thomas Tousseyn, Judith V.M.G. Bovée, Lianne Koens, Arjan Diepstra, Arjen H.G. Cleven, Marie José Kersten, Patty M. Jansen, Hendrik Veelken, Marcel Nijland, Tim J.A. Dekker, Joost S.P. Vermaat
Whole-body CD8+ T-cell PET imaging in patients with large B-cell lymphoma before and during CD19-directed CAR T-cell therapy: a phase 2 study.
Published in: Nature Communications
Access to document 10.1038/s41467-025-66767-9 document
Chimeric antigen receptor T-cell therapy (CART) has revolutionized the treatment of patients with refractory/relapsed large B-cell lymphoma (R/R LBCL). Limited biopsy data indicate that a higher activated CD8 + T-cell density is associated with tumor response. However, tumor biopsies fail to capture the systemic kinetics of CD8 + T-cells. Therefore, we conducted an exploratory phase 2 single-arm trial utilizing a zirconium-89-labeled one-armed anti-CD8α antibody ( 89ZED88082A) to enable whole-body imaging of CD8 + T-cells through positron emission tomography (PET) (NL9034; EUCTR2020-004749-35-NL). Imaging analysis was performed in 23 patients...
Janneke W de Boer, Kylie Keijzer, Jaap A van Doesum, Nienke A M Smit, Adrienne H Brouwers, Joyce van Sluis, Marjolijn N Lub-de Hooge, Frank R Pierik, Gerwin A Huls, Lisanne V van Dijk, Lydia Visser, Arjan Diepstra, Walter Noordzij, Simon P Williams, Alexander Ungewickell, Sjoerd G Elias, Elisabeth G E de Vries, Anne G H Niezink, Tom van Meerten
MATRix and HD-MTX/IFO/DEP treatment and autologous stem cell transplantation in secondary central nervous system lymphoma: a Dutch retrospective analysis
Published in: Haematologica
Access to document 10.3324/haematol.2025.287485 document
Fleur A De Groot, Floriske G Stedema, Esther J Kret, Lorraine M De Haan, Patty M Jansen, Stefan Böhringer, Arjan Diepstra, Marjolein W M Van der Poel, Myrurgia Abdul Hamid, Liane C J Te Boome, Valeska Terpstra, Mirian Brink, Hendrik Veelken, Ruben A L De Groen, Tim J A Dekker, Marcel Nijland, Joost S P Vermaat
Urinary endotrophin as a biomarker for T cell-mediated rejection-associated fibrogenesis in kidney transplant recipients
Published in: Clinical Kidney Journal
Access to document 10.1093/ckj/sfaf301 document
BACKGROUND: Endotrophin, a C-terminal pro-collagen type VIα3 fragment, has been shown to correlate with kidney interstitial fibrosis, kidney outcome measures and survival in various kidney diseases and kidney transplantation. In this study we investigated whether endotrophin is associated with fibrogenesis in T cell-mediated rejection (TCMR), allowing its use as a non-invasive biomarker. METHOD: Plasma endotrophin and urinary endotrophin (indexed for creatinine) were measured in samples from a cross-sectional study among kidney transplant recipients (KTRs) who underwent indication biopsy after transplantation and enrolled in TransplantLines Biobank and Cohort Study....
Firas F. Alkaff, Daan Kremer, Daniel G.K. Rasmussen, Nadja Sparding, Federica Genovese, Morten Karsdal, Wendy A. Dam, Marius C. Van Den Heuvel, Martin Tepel, Olivier Thaunat, Coby Annema, Stephan J.L. Bakker, Stefan P. Berger, Hans Blokzijl, Frank A.J.A. Bodewes, Marieke T. De Boer, Kevin Damman, Martin H. De Borst, Arjan Diepstra, Gerard DijkstraCaecilia S.E. Doorenbos, Rianne M. Douwes, Michele F. Eisenga, Michiel E. Erasmus, C. Tji Gan, Antonio W. Gomes Neto, Eelko Hak, Bouke G. Hepkema, Jip Jonker, Frank Klont, Tim J. Knobbe, Daan Kremer, Henri G.D. Leuvenink, Willem S. Lexmond, Vincent E. De Meijer, Hubert G.M. Niesters, Gertrude J. Nieuwenhuijs-Moeke, L. Joost Van Pelt, Robert A. Pol, Anna M. Posthumus, Adelita V. Ranchor, Jan Stephan F. Sanders, Marion J. Siebelink, Riemer J.H.J.A. Slart, J. Casper Swarte, Daan J. Touw, Marius C. Van Den Heuvel, Coretta Van Leer-Buter, Marco Van Londen, Charlotte A. Te Velde Keyzer, Erik A.M. Verschuuren, Michel J. Vos, Rinse K. Weersma, Stefan P. Berger, Jacob Van Den Born, Stephan J.L. Bakker
Multi-cohort high-dimensional proteomics reveals early risk markers for lymphoid cancer subtypes
Published in: Nature Communications
Access to document 10.1038/s41467-025-64534-4 document
This study aims to investigate the early stages of lymphoid malignancy pathogenesis and identify pre-diagnostic proteomic markers for lymphoma. Using the SomaScan-7K platform, we analyze 6412 unique plasma proteins in a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, comprising 4565 participants (484 incident lymphoid malignancy cases, median follow-up 9 years). We identify over 500 unique protein-lymphoid malignancy associations. Enriched pathways include viral protein interactions, cytokine signaling, B-cell receptor signaling, and NF-κB activation, reflecting key mechanisms in lymphoma pathogenesis. Cross-cohort validation of...
P Martijn Kolijn, Karl Smith-Byrne, Vernon Burk, Vivian Viallon, Matthew A Lee, Keren Papier, Ziqiao Wang, Anton W Langerak, Florentin Späth, Arjan Diepstra, Christina M Lill, Raul Zamora-Ros, Alessandra Macciotta, Amaia Aizpurua, Rosario Tumino, Nilanjan Chatterjee, Ruth C Travis, Marc J Gunter, Elizabeth A Platz, Elio RiboliJames McKay, Roel C H Vermeulen