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Arjan Diepstra

As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.

Clonal hematopoiesis and UBA1 mutations in individuals with biopsy-proven giant cell arteritis and population-based controls
Published in: Rheumatology
Jonas B Salzbrunn, Isabelle A van Zeventer, Aniek O de Graaf, Priscilla Kamphuis, Maaike G J M van Bergen, Yannick van Sleen, Bert A van der Reijden, Jan Jacob Schuringa, Elisabeth Brouwer, Arjan Diepstra, Joop H Jansen, Gerwin Huls
Demographics and additional haematologic cancers of patients with histiocytic/dendritic cell neoplasms
Published in: Histopathology
AIMS: The discovery of somatic genetic alterations established many histiocytic disorders as haematologic neoplasms. We aimed to investigate the demographic characteristics and additional haematologic cancers of patients diagnosed with histiocytic disorders in The Netherlands. METHODS AND RESULTS: We retrieved data on histiocytosis patients from the Dutch Nationwide Pathology Databank (Palga). During 1993 to 2022, more than 4000 patients with a pathologist-assigned diagnosis of a histiocytic disorder were registered in Palga. Xanthogranulomas were the most common subtype, challenging the prevailing assumption that Langerhans cell histiocytosis (LCH) is the most...
Paul G Kemps, Lennart Kester, Marijn A Scheijde-Vermeulen, Carel J M van Noesel, Robert M Verdijk, Arjan Diepstra, Ariënne M W van Marion, Natasja Dors, Cor van den Bos, Annette H Bruggink, Pancras C W Hogendoorn, Astrid G S van Halteren
TOX as a new diagnostic marker for T cell large granular lymphocytic leukaemia
Published in: Histopathology
AIMS: T cell large granular lymphocytic leukaemia (T-LGLL) is a rare disorder that may underlie otherwise unexplained cytopenias. The identification of T-LGLL cells in bone marrow biopsies can be a challenge, because a robust immunohistochemistry marker is lacking. The markers currently in use (granzyme B, TIA-1 and CD8) are difficult to interpret or lack specificity. Therefore, we investigated whether immunohistochemistry for thymocyte selection-associated high-mobility group box (TOX), a transcription factor that associates with chronic T cell stimulation, could be a reliable tool for the identification of T-LGLL cells....
Manske M L Burg, Lydia Visser, Arjan Diepstra
Health-related quality of life is linked to the gut microbiome in kidney transplant recipients
Published in: Nature Communications
Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. Here, we investigate the association between the gut microbiome and HRQoL in KTR, using metagenomic sequencing data from fecal samples collected from 507 KTR. Multiple bacterial species are associated with lower HRQoL, many of which have previously been associated with adverse health conditions. Gut microbiome distance to the general population is highest among KTR with an impaired...
Elevated serum TARC levels precede classic Hodgkin lymphoma diagnosis by several years
Published in: Blood
Tumor cells in classic Hodgkin lymphoma produce high quantities of the chemokine TARC. We measured TARC levels in pre-diagnostic serum samples and found strikingly increased values in the vast majority of patients, up to over six years before diagnosis.
Arjan Diepstra, Ilja M Nolte, Anke van den Berg, Larry I Magpantay, Otoniel Martinez-Maza, Lynn I Levin