Walter Noordzij
dr.
In my profession as a nuclear medicine physician, I’m involved in both clinical and scientific applications of nuclear medicine and radiology modalities. My main interests include haematology, general oncology, radio-immunotherapy, and especially the implementation of new therapeutic strategies. Currently, I have a special interest in imaging post-transplant lymphoproliferative disease, as well as radio-immunotherapy in chemotherapy refractory (non)-Hodgkin’s lymphoma.
Influence of Ultra-Low-Dose CT on PET Image Quantification and Visual Assessment
Published in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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10.2967/jnumed.124.269188
Recent advances in high-sensitivity PET allow for significantly reduced radiation doses, making the CT radiation dose a larger fraction of the total scan dose. This is the first study to the best of our knowledge that evaluates the feasibility and efficacy of an ultra-low-dose CT (ULD-CT) protocol, incorporating a Sn filter, by reducing radiation exposure while maintaining PET image quality and quantitative accuracy in oncology patients. Methods: The study involved 29 oncology patients. FDG PET/CT scans were performed using both low-dose CT (LD-CT) and ULD-CT protocols. The ULD-CT...
Metastatic mismatch repair deficient oesophageal squamous cell carcinoma leading to diagnosis of Lynch syndrome with a complete response to nivolumab treatment
Published in: Virchows Archiv : an International Journal of Pathology
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10.1007/s00428-025-04269-1
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A 59-year-old woman with two colorectal adenocarcinomas in 2015 and 2022 (both with loss of MSH2 and focal presence of MSH6 protein, thus MMR-deficient profile) had a variant of c.1012G > C p.(Gly338Arg) in the MSH2 gene, classified as Variant of Uncertain Significance (VUS) in 2023. That year, she was also diagnosed with oesophageal squamous cell carcinoma (ESCC), again MMR-deficient. Although uncommon, a proportion of ESCC can be MMR-deficient. The ESCC showed complete response to nivolumab. Genetic studies of the three tumours showed the same germline variant. During follow-up, the...
H H Wang, G Kats-Ugurlu, R H Sijmons, J L Kluiver, S Z Commandeur-Jan, W Noordzij, B van Etten, J T M Plukker, G A P Hospers, D G Knapen
Financial illiteracy among internal medicine, surgery, and radiology residents regarding medical imaging costs in the Netherlands
Published in: European Radiology
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10.1007/s00330-025-11510-7
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PURPOSE: To assess the knowledge of internal medicine, surgery, and radiology residents of medical imaging costs at a university hospital in the Netherlands. METHODS: A survey was conducted among internal medicine, surgery, and radiology residents at a tertiary care university hospital to determine their knowledge and view on medical imaging costs. Participants were asked to estimate the costs of a two-view chest X-ray, unenhanced CT of the brain, unenhanced MRI of the brain, contrast-enhanced CT of the chest and abdomen, ultrasound of the complete abdomen, and FDG-PET and...
Reflections on the PEACE V-STORM trial
Published in: Lancet Oncology
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10.1016/S1470-2045(25)00365-1
Motion-resolved parametric imaging derived from short dynamic [18F]FDG PET/CT scans.
Published in: Physica medica-European journal of medical physics
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10.1016/j.ejmp.2025.105010
PURPOSE: This study aims to assess the added value of utilizing short-dynamic whole-body PET/CT scans and implementing motion correction before quantifying metabolic rate, offering more insights into physiological processes. While this approach may not be commonly adopted, addressing motion effects is crucial due to their demonstrated potential to cause significant errors in parametric imaging. METHODS: A 15-minute dynamic FDG PET acquisition protocol was utilized for four lymphoma patients undergoing therapy evaluation. Parametric imaging was obtained using a population-based input function (PBIF) derived from twelve patients with full 65-minute...
Alessia Artesani, Joyce van Sluis, Laura Providência, Johannes H van Snick, Riemer H J A Slart, Walter Noordzij, Charalampos Tsoumpas