Walter Noordzij
dr.
In my profession as a nuclear medicine physician, I’m involved in both clinical and scientific applications of nuclear medicine and radiology modalities. My main interests include haematology, general oncology, radio-immunotherapy, and especially the implementation of new therapeutic strategies. Currently, I have a special interest in imaging post-transplant lymphoproliferative disease, as well as radio-immunotherapy in chemotherapy refractory (non)-Hodgkin’s lymphoma.
Is work overload associated with diagnostic errors on 18F-FDG-PET/CT?
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-023-06543-3
PURPOSE: To determine the association between workload and diagnostic errors on 18F-FDG-PET/CT. MATERIALS AND METHODS: This study included 103 18F-FDG-PET/CT scans with a diagnostic error that was corrected with an addendum between March 2018 and July 2023. All scans were performed at a tertiary care center. The workload of each nuclear medicine physician or radiologist who authorized the 18F-FDG-PET/CT report was determined on the day the diagnostic error was made and normalized for his or her own average daily production (workload normalized). A workload normalized of more than...
Reduction of Metabolic Active Tumor Volume Prior to CAR T-Cell Therapy Improves Survival Outcomes in Patients with Large B-Cell Lymphoma
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10.1182/blood-2023-173947
Kylie Keijzer, Janneke W. de Boer, Jaap A. van Doesum, Walter Noordzij, Gerwin A. Huls, Lisanne V. van Dijk, Tom van Meerten, Anne G.H. Niezink
Current and Future Use of Long Axial Field-of-View Positron Emission Tomography/Computed Tomography Scanners in Clinical Oncology
Published in: Cancers
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10.3390/cancers15215173
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The latest technical development in the field of positron emission tomography/computed tomography (PET/CT) imaging has been the extension of the PET axial field-of-view. As a result of the increased number of detectors, the long axial field-of-view (LAFOV) PET systems are not only characterized by a larger anatomical coverage but also by a substantially improved sensitivity, compared with conventional short axial field-of-view PET systems. In clinical practice, this innovation has led to the following optimization: (1) improved overall image quality, (2) decreased duration of PET examinations, (3) decreased amount...
Mostafa Roya, Samaneh Mostafapour, Philipp Mohr, Laura Providência, Zekai Li, Johannes H van Snick, Adrienne H Brouwers, Walter Noordzij, Antoon T M Willemsen, Rudi A J O Dierckx, Adriaan A Lammertsma, Andor W J M Glaudemans, Charalampos Tsoumpas, Riemer H J A Slart, Joyce van Sluis
PSMA PET/CT based clinical target volume delineation guideline for post-prostatectomy salvage radiation therapy: the PERYTON-Guideline
Published in: International Journal of Radiation Oncology, Biology, Physics
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10.1016/j.ijrobp.2023.09.016
PURPOSE: PSMA PET/CT scan is the standard imaging procedure for biochemical recurrent prostate cancer post-prostatectomy due to its high detection rate at low serum PSA levels. However, existing guidelines for clinical target volume (CTV) in prostate bed salvage external beam radiation therapy (sEBRT) are primarily based on experience-based clinical consensus and have been validated using conventional imaging modalities. Therefore, this study aimed to optimize CTV definition in sEBRT by utilizing PSMA PET/CT-detected local recurrences (LRs). METHODS AND MATERIALS: Patients with suspected LR on PSMA PET/CT post-prostatectomy were retrospectively...
F H E Staal, J Janssen, D E Oprea-Lager, A M Engelen, E J van Limbergen, R J Smeenk, M A A de Jong, T C G Budiharto, I Jacobs, M A D Haverkort, C L Brouwer, K Ng Wei Siang, J A Langendijk, J F Verzijlbergen, I J de Jong, W Noordzij, S Aluwini
Genomic profiling of post-transplant lymphoproliferative disorders using cell-free DNA
Published in: Journal of Hematology and Oncology
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10.1186/s13045-023-01500-x
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Diagnosing post-transplant lymphoproliferative disorder (PTLD) is challenging and often requires invasive procedures. Analyses of cell-free DNA (cfDNA) isolated from plasma is minimally invasive and highly effective for genomic profiling of tumors. We studied the feasibility of using cfDNA to profile PTLD and explore its potential to serve as a screening tool. We included seventeen patients with monomorphic PTLD after solid organ transplantation in this multi-center observational cohort study. We used low-coverage whole genome sequencing (lcWGS) to detect copy number variations (CNVs) and targeted next-generation sequencing (NGS) to identify...
Nick Veltmaat, Yujie Zhong, Filipe Montes de Jesus, Geok Wee Tan, Johanna A.A. Bult, Martijn M. Terpstra, Pim G.N.J. Mutsaers, Wendy B.C. Stevens, Rogier Mous, Joost S.P. Vermaat, Martine E.D. Chamuleau, Walter Noordzij, Erik A.M. Verschuuren, Klaas Kok, Joost L. Kluiver, Arjan Diepstra, Wouter J. Plattel, Anke van den Berg, Marcel Nijland