Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Improved [18F]FDG PET/CT Diagnostic Accuracy for Infective Endocarditis Using Conventional Cardiac Gating or Combined Cardiac and Respiratory Motion Correction (CardioFreezeTM)
Published in: Diagnostics
Access to document
10.3390/diagnostics13193146
document
Infective endocarditis (IE) is a serious and diagnostically challenging condition. [18F]FDG PET/CT is valuable for evaluating suspected IE, but it is susceptible to motion-related artefacts. This study investigated the potential benefits of cardiac motion correction for [18F]FDG PET/CT. In this prospective study, patients underwent [18F]FDG PET/CT for suspected IE, combined with a conventional cardiac gating sequence, a data-driven cardiac and respiratory gating sequence (CardioFreezeTM), or both. Scans were performed in adherence to EANM guidelines and assessors were blinded to patients’ clinical contexts. Final diagnosis of IE was established...
FDG-PET/CT discriminates between patients with and without lymphomas in primary Sjögren’s syndrome
Published in: Rheumatology
Access to document
10.1093/rheumatology/kead071
document
OBJECTIVES: To assess the usefulness of FDG-PET/CT 1) to discriminate between pSS patients with and without lymphomas and 2) to evaluate systemic disease activity in pSS. METHODS: ACR-EULAR-positive pSS patients who underwent FDG-PET/CT were included. Scans were visually evaluated and quantitative analysis was performed by measuring standardized uptake values (SUV) of salivary and lacrimal glands and systemic regions. ROC analyses were performed to find SUV cut-off values to discriminate between lymphoma and non-lymphoma. RESULTS: 26 of the 70 included patients were diagnosed with a pSS-associated lymphoma, mostly of...
PET/MRI in practice: a clinical centre survey endorsed by the European Association of Nuclear Medicine (EANM) and the EANM Forschungs GmbH (EARL)
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Access to document
10.1007/s00259-023-06308-y
document
Niek H.J. Prakken, Florent L. Besson, Ronald J.H. Borra, Florian Büther, Ronny R. Buechel, Ciprian Catana, Arturo Chiti, Rudi A.J.O. Dierckx, Marc R. Dweck, Paola A. Erba, Andor W.J.M. Glaudemans, Lars C. Gormsen, Ivalina Hristova, Michel Koole, Thomas C. Kwee, Felix M. Mottaghy, Irene Polycarpou, Mathias Prokop, Lars Stegger, Charalampos TsoumpasRiemer H.J.A. Slart
Importance of Blood Glucose Management Before 18F-FDG PET/CT in 322 Patients with Bacteremia of Unknown Origin
Published in: Journal of Nuclear Medicine
Access to document
10.2967/jnumed.122.264839
document
We investigated the effects of blood glucose levels on the performance of 18F-FDG PET/CT for detecting an infection focus in patients with bacteremia. Methods: A total of 322 consecutive patients with bacteremia who underwent 18F-FDG PET/CT between 2010 and 2021 were included. Logistic regression analysis was performed to evaluate the association between finding a true-positive infection focus on 18F-FDG PET/CT and blood glucose level, type of diabetes, and use of hypoglycemic medication. C-reactive protein, leukocyte count, duration of antibiotic treatment, and type of isolated bacteria were considered as...
[18F]FDG-PET/CT in mechanically ventilated critically ill patients with COVID-19 ARDS and persistent inflammation
Published in: Clinical and Translational Imaging
Access to document
10.1007/s40336-023-00550-y
document
Purpose: We report the findings of four critically ill patients who underwent an [18F]FDG-PET/CT because of persistent inflammation during the late phase of their COVID-19. Methods: Four mechanically ventilated patients with COVID-19 were retrospectively discussed in a research group to evaluate the added value of [18F]FDG-PET/CT. Results: Although pulmonary PET/CT findings differed, bilateral lung anomalies could explain the increased CRP and leukocytes in all patients. This underscores the limited ability of the routine laboratory to discriminate inflammation from secondary infections. Based on PET/CT findings, a secondary infection/inflammatory focus...
Bram van Leer, Johannes H. van Snick, Mark Londema, Maarten W.N. Nijsten, Ömer Kasalak, Riemer H.J.A. Slart, Andor W.J.M. Glaudemans, Janesh Pillay