Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Added value of semi-quantitative analysis of [18F]FDG PET/CT for the diagnosis of device-related infections in patients with a left ventricular assist device
Published in: European heart journal. Cardiovascular Imaging
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10.1093/ehjci/jeac260
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AIMS: Left ventricular assist devices (LVADs) improve quality of life and survival in patients with advanced heart failure, but device-related infections (DRIs) remain cumbersome. We evaluated the diagnostic capability of [18F]FDG PET/CT, factors affecting its accuracy, and the additive value of semi-quantitative analysis for the diagnosis of DRI. METHODS AND RESULTS: LVAD recipients undergoing [18F]FDG PET/CT between 2012 and 2020 for suspected DRI were retrospectively included. [18F]FDG PET/CT was performed and evaluated in accordance with EANM guidelines. The final diagnosis of DRI, based on multidisciplinary consensus and findings...
Derk Ten Hove, Ali R Wahadat, Riemer H J A Slart, Marjan Wouthuyzen-Bakker, Gianclaudio Mecozzi, Kevin Damman, Hester Witteveen, Kadir Caliskan, Olivier C Manintveld, Bhanu Sinha, Ricardo P J Budde, Andor W J M Glaudemans
[18F]FDG and [18F]FES PET/CT Imaging as a Biomarker for Therapy Effect in Patients with Metastatic ER+ Breast Cancer Undergoing Treatment with Rintodestrant
Published in: Clinical Cancer Research
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10.1158/1078-0432.CCR-22-2720
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PURPOSE: Positron emission tomography (PET) with 16α-[18F]-fluoro-17β-estradiol ([18F]FES) allows assessment of whole body estrogen receptor (ER) expression. The aim of this study was to investigate [18F]fluorodeoxyglucose ([18F]FDG) and [18F]FES PET/CT imaging for response prediction and monitoring of drug activity in patients with metastatic ER+ breast cancer undergoing treatment with the selective estrogen receptor downregulator (SERD) rintodestrant. PATIENTS AND METHODS: In this trial (NCT03455270), PET/CT imaging was performed at baseline ([18F]FDG and [18F]FES), during treatment and at time of progression (only [18F]FES). Visual, quantitative and mutational analysis was performed...
Ramsha Iqbal, Maqsood Yaqub, Husseyin O Bektas, Daniela E Oprea-Lager, Elisabeth G E de Vries, Andor W J M Glaudemans, Philippe Aftimos, Géraldine Gebhart, Andrew P Beelen, Robert C Schuit, Albert D Windhorst, Ronald Boellaard, C Willemien Menke-van der Houven van Oordt
Positron Emission Tomography Imaging in Vasculitis
Published in: Cardiology Clinics
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10.1016/j.ccl.2023.01.012
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Systemic vasculitides comprise a group of autoimmune diseases affecting blood vessels. [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) plays an important role in the diagnosis and therapeutic monitoring of vasculitides affecting large-sized and medium-sized vessels. FDG-PET/CT also provides complementary information to other vascular imaging tools. The resolution and sensitivity of newer generation scanners continues to increase, hereby improving the ability of FDG-PET/CT to accurately assess the full disease extent in patients with vasculitis. Novel tracers targeting specific immune cells will allow for more detailed detection of vascular infiltrates.
Kornelis S.M. van der Geest, Berend G.C. Slijkhuis, Alessandro Tomelleri, Olivier Gheysens, William F. Jiemy, Costanza Piccolo, Pieter Nienhuis, Maria Sandovici, Elisabeth Brouwer, Andor W.J.M. Glaudemans, Douwe J. Mulder, Riemer H.J.A. Slart
Preclinical evaluation of 2-[18F]fluorodeoxysorbitol as a tracer for targeted imaging of Enterobacterales infection.
Published in: International journal of medical microbiology
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10.1016/j.ijmm.2023.151581
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Fluorine-18-fluorodeoxyglucose ([ 18F]FDG) positron emission tomography ( 18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. Although this modality has proven to be a useful diagnostic tool, reliable distinction of bacterial infection from sterile inflammation or even from a malignancy remains challenging. Therefore, there is a need for bacteria-specific tracers for PET imaging that facilitate a reliable distinction of bacterial infection from other pathology. The present study was aimed at exploring the potential of 2-[ 18F]-fluorodeoxysorbitol ([ 18F]FDS) as a tracer for detection of Enterobacterales...
Role of 18F-FDG PET/CT in Large Vessel Vasculitis and Polymyalgia Rheumatica
Published in: Journal of Nuclear Medicine
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10.2967/jnumed.122.265016
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Systemic vasculitides comprise a group of autoimmune diseases affecting blood vessels, including large vessel vasculitis (LVV) and medium-sized vessel vasculitis such as giant cell arteritis (GCA) and Takayasu arteritis (TAK). GCA frequently overlaps with polymyalgia rheumatica (PMR), a rheumatic inflammatory condition affecting bursae, tendons or tendon sheaths, and joints. 18F-FDG PET/CT plays an important role in the diagnostic work-up of GCA, PMR, and TAK and is increasingly used to monitor treatment response. This continuing education article provides up-to-date guidance on the role of 18F-FDG PET/CT in patients with...
Riemer H.J.A. Slart, Pieter H. Nienhuis, Andor W.J.M. Glaudemans, Elisabeth Brouwer, Olivier Gheysens, Kornelis S.M. van der Geest