I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists.
Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Long Axial Field of View PET/CT: Technical Aspects in Cardiovascular Diseases
Published in: Seminars in Nuclear Medicine
Positron emission tomography / computed tomography (PET/CT) plays a pivotal role in the assessment of cardiovascular diseases (CVD), particularly in the context of ischemic heart disease. Nevertheless, its application in other forms of CVD, such as infiltrative, infectious, or inflammatory conditions, remains limited. Recently, PET/CT systems with an extended axial field of view (LAFOV) have been developed, offering greater anatomical coverage and significantly enhanced PET sensitivity. These advancements enable head-to-pelvis imaging with a single bed position, and in systems with an axial field of view (FOV) of approximately...
Tonantzin Samara Martinez-Lucio,
Oscar Isaac Mendoza-Ibañez,
Wanling Liu,
Samaneh Mostafapour,
Zekai Li,
Laura Providência, Giordana Salvi de Souza,
Philipp Mohr,
Magdalena M Dobrolinska, Bram van Leer, Hendrea S A Tingen,
Joyce van Sluis,
Charalampos Tsoumpas,
Andor W J M Glaudemans,
Klaas Pieter Koopmans,
Adriaan A Lammertsma,
Riemer H J A Slart
Fetal dose minimization: ultra-low dose long axial field of view (LAFOV) PET/CT imaging of a pregnant patient
Published in: European Journal of Nuclear Medicine and Molecular Imaging
A cutting-edge technology for the future of nuclear medicine
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Using machine learning to improve the diagnostic accuracy of the modified Duke/ESC 2015 criteria in patients with suspected prosthetic valve endocarditis: a proof of concept study
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Introduction: Prosthetic valve endocarditis (PVE) is a serious complication of prosthetic valve implantation, with an estimated yearly incidence of at least 0.4-1.0%. The Duke criteria and subsequent modifications have been developed as a diagnostic framework for infective endocarditis (IE) in clinical studies. However, their sensitivity and specificity are limited, especially for PVE. Furthermore, their most recent versions (ESC2015 and ESC2023) include advanced imaging modalities, e.g., cardiac CTA and [18F]FDG PET/CT as major criteria. However, despite these significant changes, the weighing system using major and minor criteria has remained...
D. ten Hove,
R. H.J.A. Slart,
A. W.J.M. Glaudemans,
D. F. Postma,
A. Gomes, L. E. Swart, W. Tanis, P. P. van Geel,
G. Mecozzi, R. P.J. Budde, K. Mouridsen,
B. Sinha
Current and Emerging Radiotracers in Molecular Cardiovascular Imaging
Published in: Circulation-Cardiovascular Imaging
Cardiovascular imaging has rapidly advanced over the past decades. Traditional imaging techniques such as echocardiography, computed tomography, and cardiovascular magnetic resonance are essential for assessing the structural and functional aspects of the cardiovascular system but often fall short in providing direct insights into disease activity. This gap is increasingly being bridged by molecular nuclear imaging techniques, including positron emission tomography and single-photon emission computed tomography, which enable the visualization of disease processes at the molecular and cellular levels. This review highlights the role of cardiovascular molecular imaging, emphasizing...
Shruti S Joshi, Jolien Geers, Alessia Gimelli, Fabien Hyafil, Gilbert Habib, Paola Erba, Olivier Gheysens,
Andor W J M Glaudemans, David E Newby,
Riemer H J A Slart, Marc R Dweck