Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Long Versus Short Axial Field of View Immuno-PET/CT: Semiquantitative Evaluation for 89Zr-Trastuzumab
Published in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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10.2967/jnumed.123.265621
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The purpose of this study was to quantify any differences between the SUVs of 89Zr immuno-PET scans obtained using a PET/CT system with a long axial field of view (LAFOV; Biograph Vision Quadra) compared to a PET/CT system with a short axial field of view (SAFOV; Biograph Vision) and to evaluate how LAFOV PET scan duration affects image noise and SUV metrics. Methods: Five metastatic breast cancer patients were scanned consecutively on SAFOV and LAFOV PET/CT scanners. Four additional patients were scanned using only LAFOV PET/CT. Scans on...
Philipp Mohr, Joyce van Sluis, Laura Providência, Johannes H van Snick, Marjolijn N Lub-de Hooge, Antoon T Willemsen, Andor W J M Glaudemans, Ronald Boellaard, Adriaan A Lammertsma, Adrienne H Brouwers, Charalampos Tsoumpas
Variability of [18F]FDG-PET/LDCT reporting in vascular graft and endograft infection
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-023-06349-3
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PURPOSE: 18F-fluoro-D-deoxyglucose positron emission tomography with low dose and/or contrast enhanced computed tomography ([ 18F]FDG-PET/CT) scan reveals high sensitivity for the diagnosis of vascular graft and endograft infection (VGEI), but lower specificity. Reporting [ 18F]FDG-PET/CT scans of suspected VGEI is challenging, reader dependent, and reporting standards are lacking. The aim of this study was to evaluate variability of [ 18F]FDG-PET/low dose CT (LDCT) reporting of suspected VGEI using a proposed standard reporting format. METHODS: A retrospective cohort study was conducted including all patients with a suspected VGEI (according...
David J Liesker, Stijn Legtenberg, Paola A Erba, Andor W J M Glaudemans, Clark J Zeebregts, Jean-Paul P M De Vries, Nabil Chakfé, Ben R Saleem, Riemer H J A Slart
Current and Future Use of Long Axial Field-of-View Positron Emission Tomography/Computed Tomography Scanners in Clinical Oncology
Published in: Cancers
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10.3390/cancers15215173
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The latest technical development in the field of positron emission tomography/computed tomography (PET/CT) imaging has been the extension of the PET axial field-of-view. As a result of the increased number of detectors, the long axial field-of-view (LAFOV) PET systems are not only characterized by a larger anatomical coverage but also by a substantially improved sensitivity, compared with conventional short axial field-of-view PET systems. In clinical practice, this innovation has led to the following optimization: (1) improved overall image quality, (2) decreased duration of PET examinations, (3) decreased amount...
Mostafa Roya, Samaneh Mostafapour, Philipp Mohr, Laura Providência, Zekai Li, Johannes H van Snick, Adrienne H Brouwers, Walter Noordzij, Antoon T M Willemsen, Rudi A J O Dierckx, Adriaan A Lammertsma, Andor W J M Glaudemans, Charalampos Tsoumpas, Riemer H J A Slart, Joyce van Sluis
SARS-CoV-2 Affects Thyroid and Adrenal Glands: An 18F-FDG PET/CT Study
Published in: Biomedicines
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10.3390/biomedicines11112899
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BACKGROUND: Since most endocrine glands express ACE-2 receptors and can be infected by SARS-CoV-2 virus, this retrospective multicentre observational study aims to assess the metabolic activity of thyroid and adrenal glands of COVID-19 patients by 18F-FDG PET/CT. METHODS: We retrospectively evaluated the 18F-FDG PET/CT scans of COVID-19 patients admitted by three different centres, either in a low-intensity department or in the intensive care unit (ICU). A visual assessment and a semi-quantitative evaluation of areas of interest in thyroid and adrenal glands were performed by recording SUVmax and SUVmean....
Chiara Lauri, Giuseppe Campagna, Andor W J M Glaudemans, Riemer H J A Slart, Bram van Leer, Janesh Pillay, Marzia Colandrea, Chiara Maria Grana, Antonio Stigliano, Alberto Signore
Improved [18F]FDG PET/CT Diagnostic Accuracy for Infective Endocarditis Using Conventional Cardiac Gating or Combined Cardiac and Respiratory Motion Correction (CardioFreezeTM)
Published in: Diagnostics
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10.3390/diagnostics13193146
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Infective endocarditis (IE) is a serious and diagnostically challenging condition. [18F]FDG PET/CT is valuable for evaluating suspected IE, but it is susceptible to motion-related artefacts. This study investigated the potential benefits of cardiac motion correction for [18F]FDG PET/CT. In this prospective study, patients underwent [18F]FDG PET/CT for suspected IE, combined with a conventional cardiac gating sequence, a data-driven cardiac and respiratory gating sequence (CardioFreezeTM), or both. Scans were performed in adherence to EANM guidelines and assessors were blinded to patients’ clinical contexts. Final diagnosis of IE was established...