I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists.
Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Current and Emerging Radiotracers in Molecular Cardiovascular Imaging
Published in: Circulation-Cardiovascular Imaging
Cardiovascular imaging has rapidly advanced over the past decades. Traditional imaging techniques such as echocardiography, computed tomography, and cardiovascular magnetic resonance are essential for assessing the structural and functional aspects of the cardiovascular system but often fall short in providing direct insights into disease activity. This gap is increasingly being bridged by molecular nuclear imaging techniques, including positron emission tomography and single-photon emission computed tomography, which enable the visualization of disease processes at the molecular and cellular levels. This review highlights the role of cardiovascular molecular imaging, emphasizing...
Shruti S Joshi, Jolien Geers, Alessia Gimelli, Fabien Hyafil, Gilbert Habib, Paola Erba, Olivier Gheysens,
Andor W J M Glaudemans, David E Newby,
Riemer H J A Slart, Marc R Dweck
Paediatric Dose Optimization for Long Axial Field-ofView FDG PET/CT
Aim/Introduction: Paediatric patients are more radiationsensitive, therefore minimizing exposure during imaging is vital, while tailoring protocols to their varying sizes and ages is complex. The European Association of Nuclear Medicine (EANM) developed the paediatric dose card, a tool helping to determine safe and sufcient tracer activity levels. This dose card relies on data from large retrospective paediatric patient cohorts. Consequently failing to incorporate recent breakthroughs in whole-body and long axial feld-of-view (LAFOV) PET/CT imaging, which hold signifcant promise for reducing radiation exposure in children. This study evaluates the...
Paediatric Dose Optimization for Long Axial Field-ofView FDG PET/CT
Aim/Introduction: Paediatric patients are more radiationsensitive, therefore minimizing exposure during imaging is vital, while tailoring protocols to their varying sizes and ages is complex. The European Association of Nuclear Medicine (EANM) developed the paediatric dose card, a tool helping to determine safe and sufcient tracer activity levels. This dose card relies on data from large retrospective paediatric patient cohorts. Consequently failing to incorporate recent breakthroughs in whole-body and long axial feld-of-view (LAFOV) PET/CT imaging, which hold signifcant promise for reducing radiation exposure in children. This study evaluates the...
[18F]FDG PET/CT imaging of spinal infections
Published in: Clinical and Translational Imaging
The annual incidence of spinal infections has been rising significantly over the last years and is expected to increase even further. Spinal infections may include infection of the vertebral body and intervertebral disc (spondylodiscitis), paravertebral abscess, epidural abscess and septic arthritis of the facet joints. Positron emission tomography (PET) with [18F]FDG has high sensitivity for detecting spinal infections, may help in differentiating between spinal infection subtypes and is able to detect dissemination of infection outside the spine. [18F]FDG PET/CT is especially indicated if MRI is inconclusive, in patients...
Clinical Performance Comparison of a Long Versus a Short Axial Field-of-View PET/CT Using EARL-Compliant Reconstructions
Published in: Molecular Imaging and Biology
PURPOSE: To ensure comparable PET/CT image quality between or within centres, clinical inter-system performance comparisons following European Association of Nuclear Medicine Research Ltd. (EARL) guidelines is required. In this work the performance of the long axial field-of-view Biograph Vision Quadra is compared to its predecessor, the short axial field-of-view Biograph Vision. PROCEDURES: To this aim, patients with suspected tumour lesions received a single weight-based (3 MBq/kg) 2-deoxy-2-[ 18F]fluoro-D-glucose injection and underwent routine clinical ( ∼ 15 min) scans on the Vision and 3-min scans on the Quadra in...