Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
A systematic review for the evidence of recommendations and guidelines in hybrid nuclear cardiovascular imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-024-06597-x
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OBJECTIVES: This study aimed to evaluate the level of evidence of expert recommendations and guidelines for clinical indications and procedurals in hybrid nuclear cardiovascular imaging. METHODS: From inception to August 2023, a PubMed literature analysis of the latest version of guidelines for clinical hybrid cardiovascular imaging techniques including SPECT(/CT), PET(/CT), and PET(/MRI) was performed in two categories: (1) for clinical indications for all-in primary diagnosis; subgroup in prognosis and therapy evaluation; and for (2) imaging procedurals. We surveyed to what degree these followed a standard methodology to collect...
Florent L Besson, Giorgio Treglia, Jan Bucerius, Constantinos Anagnostopoulos, Ronny R Buechel, Marc R Dweck, Paula A Erba, Oliver Gaemperli, Alessia Gimelli, Olivier Gheysens, Andor W J M Glaudemans, Gilbert Habib, Fabian Hyafil, Mark Lubberink, Christopher Rischpler, Antti Saraste, Riemer H J A Slart
Pharmacokinetic Analysis of [18F]FES PET in the Human Brain and Pituitary Gland.
Published in: Molecular Imaging and Biology
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10.1007/s11307-023-01880-z
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PURPOSE: Estrogen receptors (ER) are implicated in psychiatric disorders. We assessed if ER availability in the human brain could be quantified using 16α-[ 18F]-fluoro-17β-estradiol ([ 18F]FES) positron emission tomography (PET). PROCEDURES: Seven post‑menopausal women underwent a dynamic [ 18F]FES PET scan with arterial blood sampling. A T1-weighted MRI was acquired for anatomical information. After one week, four subjects received a selective ER degrader (SERD), four hours before the PET scan. Pharmacokinetic analysis was performed using a metabolite-corrected plasma curve as the input function. The optimal kinetic model was...
Nafiseh Ghazanfari, Janine Doorduin, Chris W J van der Weijden, Antoon T M Willemsen, Andor W J M Glaudemans, Aren van Waarde, Rudi A J O Dierckx, Erik F J de Vries
EANM consensus document on the use of [18F]FDG PET/CT in fever and inflammation of unknown origin
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-024-06732-8
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PURPOSE: Patients with fever and inflammation of unknown origin (FUO/IUO) are clinically challenging due to variable clinical presentations with nonspecific symptoms and many differential diagnoses. Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[ 18F]fluoro-D-glucose ([ 18F]FDG) is increasingly used in FUO and IUO, but the optimal diagnostic strategy remains controversial. This consensus document aims to assist clinicians and nuclear medicine specialists in the appropriate use of [ 18F]FDG-PET/CT in FUO and IUO based on current evidence. METHODS: A working group created by the EANM infection and inflammation committee performed...
Søren Hess, Edel Noriega-Álvarez, Lucia Leccisotti, Giorgio Treglia, Domenico Albano, Anne Roivainen, Andor W J M Glaudemans, Olivier Gheysens
Salivary gland 18F-FDG-PET/CT uptake patterns in Sjögren’s syndrome and giant cell arteritis patients
Published in: Clinical and Experimental Rheumatology
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10.55563/clinexprheumatol/8qt9me
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OBJECTIVES: Wide variety in salivary gland 18F-FDG-uptake is observed in the general population. A general consensus about the usefulness of 18F-FDG-PET/CT to detect salivary gland inflammatory conditions, such as in primary Sjögren’s syndrome (pSS), is not yet clear. This study aimed to investigate whether there are differences in uptake of 18F-FDG in salivary glands among two autoimmune groups [pSS, giant cell arteritis (GCA)] and a non-autoimmune group (lung cancer). METHODS: PSS patients aged ≥50 years who underwent 18F-FDG-PET/CT were included and age-matched with GCA patients and a non-autoimmune...
Rob G J Grootelaar, Martha S van Ginkel, Pieter H Nienhuis, Suzanne Arends, Remge M Pieterman, Elisabeth Brouwer, Hendrika Bootsma, Andor W J M Glaudemans, Riemer H J A Slart
The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine
Published in: British journal of radiology
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10.1259/bjr.20230704
document
Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the average population, might provide significant health benefits for this patient group and decrease CVD morbidity and mortality. Molecular imaging provides the opportunity to assess biological processes in individuals in addition to anatomical context provided by other imaging modalities and could prove to be essential in the implementation of precision medicine in...