Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Comparative analysis of FES-PET/CT and FDG-PET/CT in patients with ER-positive metastatic invasive lobular breast cancer
Published in: European Journal of Cancer
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10.1016/j.ejca.2025.115792
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BACKGROUND: Detection of metastatic invasive lobular carcinoma (mILC) with standard imaging is challenging. 2-[18F]Fluoro-2-deoxyglucose (FDG) PET/CT is commonly used in the work-up of metastatic breast cancer (MBC), but may be suboptimal for mILC. 16α-[18F]Fluoro-17β-estradiol (FES) PET/CT measures estrogen receptor (ER) expression, which is generally high in mILC. To assess whether FES-PET/CT outperforms FDG-PET/CT, we compared the detection rate of both scans to identify mILC, in patients who were enrolled in the prospective IMPACT-MBC study. METHODS: Patients with newly diagnosed ER-positive mILC underwent baseline FDG-PET/CT, FES-PET/CT, diagnostic computed tomography...
IMPACT-Metastatic Breast Consortium, Jasmine Moustaquim, Gabriëlle E van Wonderen, Jasper J L van Geel, Michel van Kruchten, Erik F J de Vries, Agnes Jager, Evelien Kuip, Marcel P M Stokkel, Andor W J M Glaudemans, Adrienne H Brouwers, Geke A P Hospers, C Willemien Menke-van der Houven van Oordt, Bert van der Vegt, Elisabeth G E de Vries, Carolina P Schröder
Influence of Ultra-Low-Dose CT on PET Image Quantification and Visual Assessment
Published in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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10.2967/jnumed.124.269188
Recent advances in high-sensitivity PET allow for significantly reduced radiation doses, making the CT radiation dose a larger fraction of the total scan dose. This is the first study to the best of our knowledge that evaluates the feasibility and efficacy of an ultra-low-dose CT (ULD-CT) protocol, incorporating a Sn filter, by reducing radiation exposure while maintaining PET image quality and quantitative accuracy in oncology patients. Methods: The study involved 29 oncology patients. FDG PET/CT scans were performed using both low-dose CT (LD-CT) and ULD-CT protocols. The ULD-CT...
How can children benefit from total-body PET?
Published in: British journal of radiology
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10.1093/bjr/tqaf242
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The introduction of long axial field-of-view (LAFOV) PET/CT scanners marks a major advancement in paediatric nuclear medicine. These systems provide greatly enhanced sensitivity, enabling superior image quality with reduced radiopharmaceutical doses and substantially shorter scan times. This is particularly advantageous in children, who are more radiosensitive and often struggle with prolonged procedures that may require sedation. LAFOV PET/CT allows whole-body imaging in a single bed position, reducing motion artefacts, improving patient comfort, and lessening procedural anxiety. Such benefits align with the ALARA (As Low As Reasonably Achievable) principle,...
Paul J H van Snick, Sasha O V Ivashchenko, Joyce van Sluis, Limme B de Langen, Georgie C van den Oever, Mostafa Roya, Andor W J M Glaudemans, Riemer H J A Slart
Clinical evaluation of dynamic [18F]FDG PET imaging to distinguish infection from inflammation in fracture-related infections.
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-025-07563-x
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BACKGROUND: Standard [ 18F]FDG PET/CT is widely used to detect infections, but is limited in differentiating bacterial infection from inflammation due to overlapping uptake patterns. This distinction is particularly challenging in fracture-related infection (FRI), due to multiple factors, including recent surgery, soft tissue injury, fracture healing, and surgical implants. Dynamic [ 18F]FDG imaging over time may overcome this limitation by capturing a rapid, sustained uptake seen in infections, driven by ongoing immune and microbial activity, as opposed to the potentially slower uptake in inflammation. This study investigates the...
N D van Rijsewijk, M Wouthuyzen-Bakker, J H van Snick, J van Sluis, R H J A Slart, A W J M Glaudemans, F F A IJpma
Impact of Ultrahigh Sensitivity and Continuous Bed Motion on Performance Characteristics of Biograph Vision Quadra PET/CT
Published in: Journal of Nuclear Medicine
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10.2967/jnumed.125.270078
Continuous bed motion (CBM) for long-axial-field-of-view PET/CT enables swift total-body examination of patients. However, the sensitivity profile along the axial field of view (AFOV) varies significantly, and its effect on image quality when combined with CBM remains unexplored. This study assesses the effects of ultrahigh sensitivity (UHS) and CBM on recovery coefficients (RCs) and spatial resolution (SR). Methods: Phantom measurements, performed in static bed and CBM acquisition with different bed speeds (3.5, 7, 14, and 30 mm/s), were reconstructed for both high-sensitivity (HS) and UHS modes, and their...