Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Influence of androgen deprivation therapy on choline PET/CT in recurrent prostate cancer
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-013-2398-7
Purpose Recurrent prostate cancer is usually treated by combining radiotherapy and androgen deprivation therapy. To stage the cancer, choline positron emission tomography (PET)/CT can be performed. It is generally thought that androgen deprivation therapy does not influence choline PET/CT. In this article we focus on the molecular backgrounds of choline and androgens, and the results of preclinical and clinical studies performed using PET/CT. Methods Using PubMed, we looked for the relevant articles about androgen deprivation therapy and choline PET/CT. Results During ADT, a tendency of decreased uptake of...
Utility of F-18-FDG PET(/CT) in patients with systemic and localized amyloidosis
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-013-2375-1
Purpose Amyloidosis is a group of diseases characterized by deposition of fibrils and this deposition may be localized or systemic. The presence of giant cells is typical of localized AL amyloidosis in contrast to systemic amyloidosis. Because of this presence of giant cells we hypothesize that F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) may show uptake in localized amyloidosis but not in systemic amyloidosis. The aim of the study was to evaluate the utility of F-18-FDG PET/CT in distinguishing systemic amyloidosis from localized amyloidosis. Methods A retrospective search...
Fluorine-18 labeled fluorodeoxyglucose PET useful for therapy monitoring in localized AL amyloidosis?
Published in: Amyloid: Journal of protein folding disorders
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10.3109/13506129.2013.773888
Walter Noordzij, Andor W. J. M. Glaudemans, Rudi A. Dierckx, Riemer H. J. A. Slart, Alexander L. Boerboom, Bouke P. C. Hazenberg
Feasibility of Vascular Endothelial Growth Factor Imaging in Human Atherosclerotic Plaque Using Zr-89-Bevacizumab Positron Emission Tomography
Published in: Molecular imaging
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10.2310/7290.2012.00034
Intraplaque angiogenesis is associated with the occurrence of atherosclerotic plaque rupture. Cardiovascular molecular imaging can be used for the detection of rupture-prone plaques. Imaging with radiolabeled bevacizumab, a monoclonal anti-vascular endothelial growth factor (VEGF)-A, can depict VEGF levels corresponding to the angiogenic status in tumors. We determined the feasibility of Zr-89-bevacizumab imaging for the detection of VEGF in carotid endarterectomy (CEA) specimens. Five CEA specimens were coincubated with Zr-89-bevacizumab and aspecific In-111-labeled IgG to determine the specificity of bevacizumab accumulation. In 11 CEA specimens, Zr-89-bevacizumab micro-positron emission tomography...
Reza Golestani, Clark J. Zeebregts, Anton G. T. Terwisscha Van Scheltinga, Marjolijn N. Lub-de Hooge, Gooitzen M. van Dam, Andor W. J. M. Glaudemans, Rudi A. J. O. Dierckx, Rene A. Tio, Albert J. H. Suurmeijer, Hendrikus Boersma, Wouter B. Nagengast, Riemer H. J. A. Slart
Unexpected symptoms after rhTSH administration due to occult thyroid carcinoma metastasis
F-18-fluorodeoxyglucose positron emission tomography ((18)FDG-PET) scintigraphy is a useful imaging technique in the evaluation of metastasised thyroid carcinoma. Administration of recombinant human thyrotropin (rhTSH, Thyrogen (R)) increases the diagnostic yield of this procedure. Here we present a 64-year-old male who was followed for Hurthle cell carcinoma of the thyroid with several intrapulmonary metastases. He developed sudden complaints of neck pain following rhTSH administration as part of the routine preparation for a diagnostic (18)FDG-PET/CT procedure. This investigation subsequently revealed a previously undetected metastatic lesion in the first cervical vertebra,...