Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Positron emission tomography imaging of oestrogen receptor-expression in endometrial stromal sarcoma supports oestrogen receptor-targeted therapy: case report and review of the literature
Published in: European Journal of Cancer
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10.1016/j.ejca.2013.08.005
Although the majority of endometrial stromal sarcomas (ESSs) express oestrogen receptor (ER), data on the efficacy of ER-targeted therapies are scarce. Using PubMed search engine we identified nine case reports and small series in a total of 25 patients reporting on the efficacy of palliative ER-targeted therapies. Literature supports the efficacy of aromatase inhibitors after the failure of progestins, but not of the partial ER-antagonist tamoxifen. Fulvestrant is a pure ER-antagonist with a distinct mechanism, of which efficacy has not yet been reported in ESS. We present a...
Michel van Kruchten, Geke A P Hospers, Andor W J M Glaudemans, Harry Hollema, Henriëtte J G Arts, Anna K L Reyners
PET imaging of oestrogen receptors in patients with breast cancer
Oestrogen receptors are overexpressed in around 70% of all breast cancers, and are a target for endocrine therapy. These receptors can be visualised on PET with use of 16 alpha-[F-18]-fluoro-17 beta-oestradiol (F-18-FES) as a tracer. Compared with biopsy, which enables assessment of individual sites, whole-body F-18-FES-PET enables quantification of oestrogen-receptor expression in all metastases. In several studies, measurement of tumour protein expression in oestrogen receptors by F-18-FES-PET, concurrent with biopsy, detected oestrogen-receptor-positive tumour lesions with a sensitivity of 84% and specificity of 98%. Roughly 45% of patients with...
Michel van Kruchten, Elisabeth G. E. de Vries, Myles Brown, Andor W. J. M. Glaudemans, Rudi A. J. O. Dierckx, Carolien P. Schroder, Geke A. P. Hospers, Erik de Vries
A large retrospective single-centre study to define the best image acquisition protocols and interpretation criteria for white blood cell scintigraphy with Tc-99m-HMPAO-labelled leucocytes in musculoskeletal infections
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-013-2481-0
The diagnosis of infection is often based on clinical, pathological and microbiological results. However, these investigations lack specificity. White blood cell (WBC) scintigraphy is considered the gold standard nuclear imaging technique for diagnosing infections in bone and soft tissues (except spondylodiscitis). However, image acquisition and interpretation criteria differ amongst centres throughout the world, leading to differences in reported results. The aim of this study was to identify the most accurate WBC scintigraphy acquisition and interpretation protocols for diagnosis of bone and soft tissue infections. Included in this retrospective...
Andor W. J. M. Glaudemans, Erik F. J. de Vries, Liliane E. M. Vermeulen, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Alberto Signore
Myocardial perfusion reserve in spared myocardium: correlation with infarct size and left ventricular ejection fraction
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-013-2394-y
PURPOSE: Left ventricular ejection fraction (LVEF) after myocardial infarction is considered to be determined by the size of the infarction and residual function of the spared myocardium. Myocardial perfusion reserve (MPR) has been shown to be a strong prognostic factor in patients with ischaemic heart failure, even stronger than LVEF. In the present study, the interrelationship between MPR, LVEF and infarct size was investigated. METHODS: In total, 102 patients with a prior history of myocardial infarction were included. All underwent rest and stress (13)N-ammonia and gated (18)F-fluorodeoxyglucose ((18)F-FDG)...
Luis Eduardo Juárez-Orozco, Julius Glauche, Erick Alexanderson, Clark J Zeebregts, Hendrikus H Boersma, Andor W J M Glaudemans, Rudi A Dierckx, Dirk J van Veldhuisen, René A Tio, Riemer H J A Slart
Nuclear Medicine Imaging of Infl ammatory Diseases
Published in: Diagnostic Imaging of Infections and Inflammatory Diseases: A Multidisciplinary Approach
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10.1002/9781118484388.ch17
Inflammatory diseases are often relapsing and require life-long treatment. New specific targeted therapies are being developed, and several clinical trials are being performed to assess the efficacy and safety of this new approach. Nowadays, nuclear medicine techniques greatly contribute to the management and determination of the prognosis of the disease. Most importantly, nuclear medicine techniques are the most sensitive diagnostic modalities for the evaluation of disease activity. This chapter reviews molecular imaging by nuclear medicine techniques, and discusses the clinical problem and methodological considerations. It talks about normal...
Marco Chianelli, Gaurav Malviya, Andor W.J.M. Glaudemans, Alberto Signore