Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Gastrocolocutaneous fistula detected by [F-18]fluorodeoxyglucose positron emission tomography with low-dose computed tomography: a rare iatrogenic complication of colonoscopy
Published in: Endoscopy
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10.1055/s-0032-1325979
Multiagent imaging of inflammation and infection with radionuclides
Published in: Clinical and Translational Imaging
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10.1007/s40336-013-0041-z
Molecular imaging with single photon- and positron-emitting tracers plays an important role in the evaluation of inflammation and infection. Although supplanted by labeled leukocyte imaging for most indications, gallium-67 remains useful for opportunistic infections, pulmonary inflammation and interstitial nephritis and, when [18F]FDG is not available, spinal infection and fever of unknown origin. In vitro labeled leukocyte imaging is the radionuclide procedure of choice for most infections in immunocompetent patients. When performed for musculoskeletal infection, complementary bone marrow imaging usually is necessary. Recent data suggest that dual time point...
Christopher J. Palestro, Andor W.J.M. Glaudemans, Rudi A.J.O. Dierckx
Positron emission tomography imaging of oestrogen receptor-expression in endometrial stromal sarcoma supports oestrogen receptor-targeted therapy: case report and review of the literature
Published in: European Journal of Cancer
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10.1016/j.ejca.2013.08.005
Although the majority of endometrial stromal sarcomas (ESSs) express oestrogen receptor (ER), data on the efficacy of ER-targeted therapies are scarce. Using PubMed search engine we identified nine case reports and small series in a total of 25 patients reporting on the efficacy of palliative ER-targeted therapies. Literature supports the efficacy of aromatase inhibitors after the failure of progestins, but not of the partial ER-antagonist tamoxifen. Fulvestrant is a pure ER-antagonist with a distinct mechanism, of which efficacy has not yet been reported in ESS. We present a...
Michel van Kruchten, Geke A P Hospers, Andor W J M Glaudemans, Harry Hollema, Henriëtte J G Arts, Anna K L Reyners
PET imaging of oestrogen receptors in patients with breast cancer
Oestrogen receptors are overexpressed in around 70% of all breast cancers, and are a target for endocrine therapy. These receptors can be visualised on PET with use of 16 alpha-[F-18]-fluoro-17 beta-oestradiol (F-18-FES) as a tracer. Compared with biopsy, which enables assessment of individual sites, whole-body F-18-FES-PET enables quantification of oestrogen-receptor expression in all metastases. In several studies, measurement of tumour protein expression in oestrogen receptors by F-18-FES-PET, concurrent with biopsy, detected oestrogen-receptor-positive tumour lesions with a sensitivity of 84% and specificity of 98%. Roughly 45% of patients with...
Michel van Kruchten, Elisabeth G. E. de Vries, Myles Brown, Andor W. J. M. Glaudemans, Rudi A. J. O. Dierckx, Carolien P. Schroder, Geke A. P. Hospers, Erik de Vries
A large retrospective single-centre study to define the best image acquisition protocols and interpretation criteria for white blood cell scintigraphy with Tc-99m-HMPAO-labelled leucocytes in musculoskeletal infections
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-013-2481-0
The diagnosis of infection is often based on clinical, pathological and microbiological results. However, these investigations lack specificity. White blood cell (WBC) scintigraphy is considered the gold standard nuclear imaging technique for diagnosing infections in bone and soft tissues (except spondylodiscitis). However, image acquisition and interpretation criteria differ amongst centres throughout the world, leading to differences in reported results. The aim of this study was to identify the most accurate WBC scintigraphy acquisition and interpretation protocols for diagnosis of bone and soft tissue infections. Included in this retrospective...
Andor W. J. M. Glaudemans, Erik F. J. de Vries, Liliane E. M. Vermeulen, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Alberto Signore