Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
LEUKOCYTE AND BACTERIA IMAGING IN PROSTHETIC JOINT INFECTION
There has been a significant increase in the number of joint prosthesis replacements worldwide. Although relatively uncommon, complications can occur with the most serious being an infection. Various radiological and nuclear imaging techniques are available to diagnose prosthetic joint infections (PJI). In this review article, we describe the pathophysiology of PJI, the principles of nuclear medicine imaging and the differences between Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET). The value of nuclear medicine techniques for clinical practice is also discussed. Then we provide an...
Andor W. J. M. Glaudemans, Filippo Galli, Marta Pacilio, Alberto Signore
Peritoneal lymphomatosis found on 18F-FDG PET/CT
Published in: European Journal of Haematology
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10.1111/j.1600-0609.2012.01823.x
Ronald W. J. van Rheenen, Alphons H. H. Bongaerts, Andor W. J. M. Glaudemans
Clinical use of differential nuclear medicine modalities in patients with ATTR amyloidosis
Published in: Amyloid: Journal of protein folding disorders
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10.3109/13506129.2012.717993
Histological proof remains the gold standard for the diagnosis of amyloidosis. Nuclear medicine imaging techniques are able to determine the amyloid load in the body. Currently, the best imaging modality is I-123-SAP scintigraphy. This modality has high sensitivity for detecting amyloid deposits in all amyloid subtypes. Involvement of liver and spleen can be visualized before clinical signs are present. The addition of single photon emission computed tomography improves the differentiation of overlying organs. However, I-123-SAP is not FDA approved. Its availability is limited to two centres in Europe....
I-123-Labelled metaiodobenzylguanidine for the evaluation of cardiac sympathetic denervation in early stage amyloidosis
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-012-2187-8
PURPOSE: Cardiac amyloidosis is a rare disorder, but it may lead to potentially life-threatening restrictive cardiomyopathy. Cardiac manifestations frequently occur in primary amyloidosis (AL) and familial amyloidosis (ATTR), but are uncommon in secondary amyloidosis (AA). Echocardiography is the method of choice for assessing cardiac amyloidosis. Amyloid deposits impair the function of sympathetic nerve endings. Disturbance of myocardial sympathetic innervations may play an important role in the remodelling process. (123)I-MIBG can detect these innervation changes. METHODS: Patients with biopsy-proven amyloidosis underwent general work-up, echocardiography and (123)I-MIBG scintigraphy. Left ventricular...
Walter Noordzij, Andor W J M Glaudemans, Ronald W J van Rheenen, Bouke P C Hazenberg, René A Tio, Rudi A J O Dierckx, Riemer H J A Slart
Adrenal Hemorrhage Causing Adrenal Insufficiency in a Patient with Antiphospholipid Syndrome: Increased Adrenal F-18-FDG Uptake
Published in: Journal of Clinical Endocrinology and Metabolism
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10.1210/jc.2012-2050
Leo Boneschansker, Marcel Nijland, Andor W J M Glaudemans, Sibylle B van der Meulen, Philip M Kluin, Robin P F Dullaart