Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Image acquisition and interpretation criteria for Tc-99m-HMPAO-labelled white blood cell scintigraphy: results of a multicentre study
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-013-2631-4
Purpose There is no consensus yet on the best protocol for planar image acquisition and interpretation of radiolabelled white blood cell (WBC) scintigraphy. This may account for differences in reported diagnostic accuracy amongst different centres. Methods This was a multicentre retrospective study analysing 235 WBC scans divided into two groups. The first group of scans (105 patients) were acquired with a fixed-time acquisition protocol and the second group (130 patients) were acquired with a decay time-corrected acquisition protocol. Planar images were interpreted both qualitatively and semiquantitatively. Three blinded...
Paola A. Erba, Andor W. J. M. Glaudemans, Niels C. Veltman, Martina Sollini, Marta Pacilio, Filippo Galli, Rudi A. J. O. Dierckx, Alberto Signore
In vivo imaging of brain estrogen receptors in rats: A 16α-18F-fluoro-17β-estradiol PET study
Published in: Journal of Nuclear Medicine
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10.2967/jnumed.113.128751
UNLABELLED: The steroid hormone estrogen is important for brain functioning and is thought to be involved in brain diseases, such as Alzheimer disease and depression. The action of estrogen is mediated by estrogen receptors (ERs). To understand the role of estrogens in brain functioning, it is important to study ERs in the brain. The aims of the present study were to determine whether ERs could be measured in the rat brain by PET with the ER ligand 16α-(18)F-fluoro-17β-estradiol ((18)F-FES) and to evaluate whether tracer uptake was affected by...
Bone scintigraphy with (99m)technetium-hydroxymethylene diphosphonate allows early diagnosis of cardiac involvement in patients with transthyretin-derived systemic amyloidosis
Published in: Amyloid: Journal of protein folding disorders
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10.3109/13506129.2013.871250
document
Objective: To assess the usefulness of bone scintigraphy with (99m)Technetium-hydroxymethylene diphosphonate (Tc-99m-HDP) for the detection of cardiac involvement in a group of patients with ATTR amyloidosis in different phases of disease, to relate the findings to echocardiography, ECG and cardiac biomarkers, and to evaluate different bone scintigraphic techniques and calculation methods for quantification of the cardiac uptake and for correlation with echocardiographic features and cardiac biomarkers. Methods: Forty-one patients underwent clinical examinations, echocardiography, ECG, measurement of cardiac biomarkers and bone scintigraphy (planar imaging and SPECT-CT) and were subsequently...
Andor W. J. M. Glaudemans, Ronald W. J. van Rheenen, Maarten P. van den Berg, Walter Noordzij, Michel Koole, Hans Blokzijl, Rudi A. J. O. Dierckx, Riemer H. J. A. Slart, Bouke P. C. Hazenberg
PET and SPECT imaging of steroid hormone receptors
Nuclear Medicine Imaging Modalities: Bone Scintigraphy, PET-CT, SPECT-CT
Published in: Bone Metastases: A translational and Clinical Approach
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10.1007/978-94-007-7569-5_5
Nuclear medicine allows imaging of (patho) physiological processes within the body and contributes in the diagnosis and treatment of specific diseases. In patients with bone metastases, nuclear medicine not only plays an important role in the diagnosis, but may also be used for therapeutic purposes. For several decades, bone scintigraphy has been used and nowadays is still the nuclear medicine imaging method of choice for diagnosing bone metastases in many malignant diseases. Its sensitivity (>90 %) is still superior to any other available imaging method. However, the specificity...