Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Vancomycin-based tracers guiding in situ visualization of bacteria on osteosynthesis devices and surgical debridement
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-025-07249-4
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PURPOSE: Bacterial infections associated with musculoskeletal injuries are challenging to detect and distinguish from sterile inflammation. Here we present the combined first-time application of a bacteria-targeted positron emission tomography (PET) tracer and a near-infrared fluorescent tracer to detect infected osteosynthesis implants and guide surgical treatment. METHODS: To this end, osteosynthesis plates covered with bacterial biofilm and pre-incubated with [ 18F]PQ-VE1-vancomycin for PET imaging and/or vancomycin-IRDye800CW for optical imaging were fixed to post-mortem human tibiae and femora. PET/CT and fluorescence imaging were used to quantify the bacterial load before...
Gerbren B Spoelstra, Philip H Elsinga, Jan Maarten van Dijl, Johannes H van Snick, Ben L Feringa, Andor W J M Glaudemans, Bas Keizers, Schelto Kruijff, Wiktor Szymanski, Marleen van Oosten, Frank F A IJpma
Correction: Bosch et al. Diagnostic Value of Increased [18F]FDG Uptake in Locoregional Lymph Nodes on PET/CT in Patients with Suspected Fracture-Related Infection. Diagnostics 2025, 15, 616.
Published in: Diagnostics
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10.3390/diagnostics15151894
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Paul Bosch, Andor W J M Glaudemans, Jean-Paul P M de Vries, Johannes H van Snick, Justin V C Lemans, Janna van den Kieboom, Monique G G Hobbelink, Geertje A M Govaert, Frank F A IJpma
Positron Emission Tomography Imaging in Vasculitis
Published in: Heart failure clinics
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10.1016/j.hfc.2025.01.007
document
Systemic vasculitides comprise a group of autoimmune diseases affecting blood vessels. [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) plays an important role in the diagnosis and therapeutic monitoring of vasculitides affecting large-sized and medium-sized vessels. FDG-PET/CT also provides complementary information to other vascular imaging tools. The resolution and sensitivity of newer generation scanners continues to increase, hereby improving the ability of FDG-PET/CT to accurately assess the full disease extent in patients with vasculitis. Novel tracers targeting specific immune cells will allow for more detailed detection of vascular infiltrates.
Kornelis S M van der Geest, Berend G C Slijkhuis, Alessandro Tomelleri, Olivier Gheysens, William F Jiemy, Costanza Piccolo, Pieter Nienhuis, Maria Sandovici, Elisabeth Brouwer, Andor W J M Glaudemans, Douwe J Mulder, Riemer H J A Slart
Current Developments on [18F]FDG PET/CT in Inflammatory Disorders of the Central Nervous System.
Published in: Seminars in Nuclear Medicine
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10.1053/j.semnuclmed.2025.06.001
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2-Deoxy-2-[ 18F]fluoro-D-glucose positron emission tomography (FDG-PET) is widely used to study cerebral glucose metabolism and may be useful in several inflammatory disorders of the central nervous system. Emerging literature suggests that [ 18F]FDG may be more sensitive to detect abnormalities in auto-immune encephalitis (AIE) in comparison to MRI, especially in NDMA receptor encephalitis. Distinct patterns of regional abnormalities in AIE have been reported, depending on the auto-antibody involved. Predominant findings are hypermetabolism of the mediotemporal lobe and hypometabolism in parietal and occipital lobes. The possibility for whole body...
The diagnostic role of 2-[18F]FDG PET/CT in critically ill patients with suspected infection of unknown origin: a real-world experience
Published in: Radiologia medica
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10.1007/s11547-025-02005-y
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PURPOSE: 2-Deoxy-2-[ 18F]-fluoro-D-glucose (2-[ 18F]FDG) positron emission tomography/computed tomography (PET/CT) is a hybrid imaging tool with an emerging role in the study of several infectious and inflammatory diseases. Its role in critically ill patients admitted to the intensive care unit (ICU) is only marginally investigated. This study aimed to investigate the diagnostic performance and the clinical impact of 2-[ 18F]FDG PET/CT in the management of critically ill patients with suspected infections of unknown origin. METHODS: We retrospectively included 47 ICU patients (mean age 63.6 years, 33 males) who...
Domenico Albano, Carlo Rodella, Anna Calabrò, Andor W J M Glaudemans, Giorgio Treglia, Francesco Bertagna