Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Feasibility of the Absolute Quantification and Left Ventricular Segmentation of Cardiac Sympathetic Innervation in Wild-type Transthyretin Amyloidosis Cardiomyopathy with [123I]-MIBG SPECT/CT: the I-NERVE study.
Published in: Journal of Nuclear Cardiology
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10.1016/j.nuclcard.2025.102146
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PURPOSE: Cardiac sympathetic neuronal dysfunction is an early marker in wild-type transthyretin amyloidosis cardiomyopathy (ATTRwt-CM). [ 123I]-MIBG imaging evaluates cardiac sympathetic innervation but lacks volumetric activity quantification in current methods. This study aims to quantify cardiac sympathetic neuronal dysfunction in ATTRwt-CM using [ 123I]-MIBG SPECT/CT and correlate findings with functional and structural cardiac parameters from echocardiogram and cardiac magnetic resonance imaging (CMR). METHODS: We conducted a single-center, descriptive, cross-sectional study to quantify absolute myocardial sympathetic function in ATTRwt-CM using [ 123I]-MIBG SPECT/CT. Retrospective reconstruction allowed for absolute tracer-uptake...
Intrapatient 16α-[18F]Fluoro-17β-Estradiol PET Heterogeneity as a Prognostic Factor for Endocrine Therapy Response and Survival in Patients with Estrogen Receptor-Positive Metastatic Breast Cancer.
Published in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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10.2967/jnumed.124.268984
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Intrapatient heterogeneity of estrogen receptor (ER) expression on 16α-[ 18F]fluoro-17β-estradiol ([ 18F]FES) PET is related to outcome in patients with ER-positive metastatic breast cancer (MBC), but a validated and practical method to support clinical decision-making is lacking. Therefore, the [ 18F]FES PET heterogeneity score (i.e., percentage of [ 18F]FES-positive metastases) was validated as a prognostic factor for endocrine therapy response and survival in a large cohort of patients with newly diagnosed MBC. Furthermore, we explored 2 less laborious methods to predict the [ 18F]FES PET heterogeneity score. Methods:...
IMPACT-Metastatic Breast Consortium, Jasper J L van Geel, Jasmine Moustaquim, Jorianne Boers, Sjoerd G Elias, Esther M M Smeets, Jelijn J Knip, Andor W J M Glaudemans, Erik F J de Vries, Geke A P Hospers, Michel van Kruchten, Marcel Stokkel, Daniela E Oprea-Lager, Willemien C Menke-van der Houven van Oordt, Elisabeth G E de Vries, Carolina P Schröder
[18F]FDG PET/CT to diagnose inflammation in critically ill immunocompromised patients.
Published in: Intensive care medicine
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10.1007/s00134-024-07723-x
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EANM/SNMMI guideline/procedure standard for [ 18F]FDG hybrid PET use in infection and inflammation in adults v2.0.
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-024-06915-3
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INTRODUCTION: Hybrid [ 18F]FDG PET imaging is currently the method of choice for a wide variety of infectious and inflammatory disorders and was recently adopted in several clinical guidelines. A large amount of evidence-based articles, guidelines and appropriate use criteria have been published since the first version of this guideline in 2013. PURPOSE: To provide updated evidence-based information to assist physicians in recommending, performing and interpreting hybrid [ 18F]FDG PET examinations for infectious and inflammatory disorders in the adult population. METHODS: A systematic literature search of evidence-based articles...
Gad Abikhzer, Giorgio Treglia, Matthieu Pelletier-Galarneau, John Buscombe, Arturo Chiti, Elizabeth H Dibble, Andor W J M Glaudemans, Christopher J Palestro, Mike Sathekge, Alberto Signore, Francois Jamar, Ora Israel, Olivier Gheysens
Long Axial Field of View PET/CT: Technical Aspects in Cardiovascular Diseases
Published in: Seminars in Nuclear Medicine
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10.1053/j.semnuclmed.2024.10.009
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Positron emission tomography / computed tomography (PET/CT) plays a pivotal role in the assessment of cardiovascular diseases (CVD), particularly in the context of ischemic heart disease. Nevertheless, its application in other forms of CVD, such as infiltrative, infectious, or inflammatory conditions, remains limited. Recently, PET/CT systems with an extended axial field of view (LAFOV) have been developed, offering greater anatomical coverage and significantly enhanced PET sensitivity. These advancements enable head-to-pelvis imaging with a single bed position, and in systems with an axial field of view (FOV) of approximately...
Tonantzin Samara Martinez-Lucio, Oscar Isaac Mendoza-Ibañez, Wanling Liu, Samaneh Mostafapour, Zekai Li, Laura Providência, Giordana Salvi de Souza, Philipp Mohr, Magdalena M Dobrolinska, Bram van Leer, Hendrea S A Tingen, Joyce van Sluis, Charalampos Tsoumpas, Andor W J M Glaudemans, Klaas Pieter Koopmans, Adriaan A Lammertsma, Riemer H J A Slart