Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Role of FDG-PET/CT in children with fever of unknown origin
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Access to document
10.1007/s00259-020-04707-z
document
PURPOSE: To determine the role of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET)/computed tomography (CT) in children with fever of unknown origin (FUO). METHODS: This retrospective single-center study included 110 children (0-18 years) with FUO who underwent FDG-PET/CT between 2010 and 2019. The diagnostic value of FDG-PET/CT for identifying cause of fever was calculated, treatment modifications after FDG-PET/CT were assessed, and logistic regression analyses were performed to identify clinical and biochemical factors associated with FDG-PET/CT outcome. RESULTS: In 53 out of 110 patients (48%), FDG-PET/CT identified a (true positive) cause...
Jordy P Pijl, Thomas C Kwee, G E Legger, Helja J H Peters, Wineke Armbrust, E H Schölvinck, Andor W J M Glaudemans
Comparison of White Blood Cell Scintigraphy, FDG PET/CT and MRI in Suspected Diabetic Foot Infection: Results of a Large Retrospective Multicenter Study
Published in: Journal of Clinical Medicine
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10.3390/jcm9061645
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Diabetic foot infections (DFIs) represent one of the most frequent and disabling morbidities of longstanding diabetes; therefore, early diagnosis is mandatory. The aim of this multicenter retrospective study was to compare the diagnostic accuracy of white blood cell scintigraphy (WBC), 18F-fluorodeoxyglucose positron emission tomography/computed tomography ((18F) FDG PET/CT), and Magnetic Resonance Imaging (MRI) in patients with suspected DFI. Images and clinical data from 251 patients enrolled by five centers were collected in order to calculate the sensitivity, specificity, and accuracy of WBC, FDG, and MRI in diagnosing osteomyelitis...
Chiara Lauri, Andor W J M Glaudemans, Giuseppe Campagna, Zohar Keidar, Marina Muchnik Kurash, Stamata Georga, Georgios Arsos, Edel Noriega-Álvarez, Giuseppe Argento, Thomas C Kwee, Riemer H J A Slart, Alberto Signore
Diagnostic performance of F-18-FDG PET/CT in patients with spinal infection: a systematic review and a bivariate meta-analysis
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-019-04571-6
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Purpose: Diagnosis of spinal infection (SI) is challenging and usually requires multiple tests. We aimed to perform a systematic review and a bivariate meta-analysis on the diagnostic role of 18F-FDG PET/CT in patients with SI. Methods: A comprehensive literature search of studies published through February 2019 in PubMed/MEDLINE and Cochrane library databases was carried out. Studies investigating the diagnostic performance of 18F-FDG PET/CT in patients with SI were eligible for inclusion in the qualitative analysis. For the quantitative analysis, pooled sensitivity, specificity, positive and negative likelihood ratio (LR+...
Giorgio Treglia, Mariarosa Pascale, Elena Lazzeri, Wouter van der Bruggen, Roberto C. Delgado Bolton, Andor W. J. M. Glaudemans
Image Quality and Activity Optimization in Oncologic F-18-FDG PET Using the Digital Biograph Vision PET/CT System
Published in: Journal of Nuclear Medicine
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10.2967/jnumed.119.234351
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The first Biograph Vision PET/CT system (Siemens Healthineers) was installed at the University Medical Center Groningen. Improved performance of this system could allow for a reduction in activity administration or scan duration. This study evaluated the effects of reduced scan duration in oncologic 18F-FDG PET imaging on quantitative and subjective imaging parameters and its influence on clinical image interpretation. Methods: Patients referred for a clinical PET/CT scan were enrolled in this study, received a weight-based 18F-FDG injected activity, and underwent list-mode PET acquisition at 180 s per bed...
Visual and quantitative evaluation of [F-18]FES and [F-18]FDHT PET in patients with metastatic breast cancer: an interobserver variability study
Published in: EJNMMI Research
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10.1186/s13550-020-00627-z
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PURPOSE: Correct identification of tumour receptor status is important for treatment decisions in breast cancer. [18F]FES PET and [18F]FDHT PET allow non-invasive assessment of the oestrogen (ER) and androgen receptor (AR) status of individual lesions within a patient. Despite standardised analysis techniques, interobserver variability can significantly affect the interpretation of PET results and thus clinical applicability. The purpose of this study was to determine visual and quantitative interobserver variability of [18F]FES PET and [18F]FDHT PET interpretation in patients with metastatic breast cancer. METHODS: In this prospective, two-centre study,...
Lemonitsa H Mammatas, Clasina M Venema, Carolina P Schröder, Henrica C W de Vet, Michel van Kruchten, Andor W J M Glaudemans, Maqsood M Yaqub, Henk M W Verheul, Epie Boven, Bert van der Vegt, Erik F J de Vries, Elisabeth G E de Vries, Otto S Hoekstra, Geke A P Hospers, C Willemien Menke-van der Houven van Oordt