Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
A phase 1b study evaluating the effect of elacestrant treatment on estrogen receptor availability and estradiol binding to the estrogen receptor in metastatic breast cancer lesions using 18F-FES PET/CT imaging
Published in: Breast cancer research
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10.1186/s13058-020-01333-3
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BACKGROUND: Elacestrant is an oral selective estrogen receptor (ER) degrader. This phase 1b open-label, non-randomized study (RAD1901-106) was initiated to determine the effect of elacestrant on the availability of ER in lesions from postmenopausal women with ER+ advanced breast cancer (ABC) using 16α-18F-fluoro-17β-estradiol positron emission tomography with low-dose computed tomography (FES-PET/CT). METHODS: Eligible patients were postmenopausal women with ER+, HER2- ABC; tumor progression after ≥ 6 months of 1-3 lines of endocrine treatment for ABC; and measurable or evaluable disease. Two 8-patient cohorts were enrolled: one treated with 400 mg elacestrant...
Agnes Jager, Elisabeth G E de Vries, C Willemien Menke-van der Houven van Oordt, Patrick Neven, Clasina M Venema, Andor W J M Glaudemans, Yamei Wang, Rebecca G Bagley, Maureen G Conlan, Philippe Aftimos
Image quality and interpretation of [F-18]-FES-PET: is there any effect of food intake?
Jorianne Boers, K. Giatagana, G. A. P. Hospers, C. P. Schroder, E. F. J. de Vries, A. W. J. M. Glaudemans
Relationship between F-18-FDG Uptake in the Oral Cavity, Recent Dental Treatments, and Oral Inflammation or Infection: A Retrospective Study of Patients with Suspected Endocarditis
Published in: Diagnostics
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10.3390/diagnostics10090625
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[F-18]-fluorodeoxyglucose positron emission tomography ([F-18]FDG PET/CT) has proven to be a useful diagnostic tool in patients with suspected infective endocarditis (IE), but is conflicting in relation to dental procedures. Questions: Is there a correlation between [F-18]FDG PET/CT findings, recent dental treatment, and an affected oral cavity? (2) Is there a correlation between infective endocarditis (IE), oral health status, and (extra)cardiac findings on [F-18]FDG PET/CT? Methods: This retrospective study included 52 patients. All [F-18]FDG PET/CT scans were examined visually by pattern recognition using a three-point scale and semi-quantified within...
Geertruida W Dijkstra, Andor W J M Glaudemans, Paola A Erba, Marjan Wouthuyzen-Bakker, Bhanu Sinha, David Vállez García, Luc W M van der Sluis, Riemer H J A Slart
F-18-FDG PET/CT in the Diagnostic and Treatment Evaluation of Pediatric Posttransplant Lymphoproliferative Disorders
Published in: Journal of Nuclear Medicine
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10.2967/jnumed.119.239624
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We aimed to evaluate the diagnostic performance of 18F-FDG PET/CT for the detection of posttransplantation lymphoproliferative disorder (PTLD) in a pediatric population and explore its feasibility during response assessment. Methods: This retrospective study included 28 pediatric transplant recipients who underwent a total of 32 18F-FDG PET/CT scans due to clinical suspicion of PTLD within an 8-y period. Pathology reports and 2 y of follow-up were used as the reference standard. Twenty-one response assessment 18F-FDG PET/CT scans were reevaluated according to the Lugano criteria. Results: The diagnosis of PTLD...
The Role of Imaging Techniques to Define a Peri-Prosthetic Hip and Knee Joint Infection: Multidisciplinary Consensus Statements
Published in: Journal of Clinical Medicine
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10.3390/jcm9082548
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Diagnosing a peri-prosthetic joint infection (PJI) remains challenging despite the availability of a variety of clinical signs, serum and synovial markers, imaging techniques, microbiological and histological findings. Moreover, the one and only true definition of PJI does not exist, which is reflected by the existence of at least six different definitions by independent societies. These definitions are composed of major and minor criteria for defining a PJI, but most of them do not include imaging techniques. This paper highlights the pros and cons of available imaging techniques-X-ray, ultrasound,...
Carlo Luca Romanò, Nicola Petrosillo, Giuseppe Argento, Luca Maria Sconfienza, Giorgio Treglia, Abass Alavi, Andor W J M Glaudemans, Olivier Gheysens, Alex Maes, Chiara Lauri, Christopher J Palestro, Alberto Signore