Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Semi-Quantitative and Quantitative [F-18]FDG-PET/CT Indices for Diagnosing Large Vessel Vasculitis: A Critical Review
Published in: Diagnostics
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10.3390/diagnostics11122355
document
To confirm the diagnosis of large vessel vasculitis (LVV) with high accuracy, one of the recommended imaging techniques is [F-18]Fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography ([F-18]FDG-PET/CT). Visual assessment of [F-18]FDG uptake in the arterial wall compared to liver uptake is the mainstay for diagnosing LVV in routine clinical practice. To date, there is no consensus on the preferred semi-quantitative or quantitative parameter for diagnosing LVV. The aim of this review is to critically update the knowledge on the available evidence of semi-quantitative and quantitative [F-18]FDG uptake parameters...
Olivier Gheysens, Francois Jamar, Andor W. J. M. Glaudemans, Halil Yildiz, Kornelis S. M. van der Geest
White Blood Cell Scintigraphy for Fracture-Related Infection: Is Semiquantitative Analysis of Equivocal Scans Accurate?
Published in: Diagnostics
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10.3390/diagnostics11122227
document
Purpose: White blood cell (WBC) scintigraphy is considered the gold-standard nuclear imaging technique for diagnosing fracture-related infection (FRI). Correct interpretation of WBC scans in FRI is important since a false positive or false negative diagnosis has major consequences for the patient in terms of clinical decision-making. The European Association of Nuclear Medicine (EANM) guideline for correct analysis and interpretation of WBC scans recommends semiquantitative analysis of visually equivocal scans. Therefore, this study aims to assess the diagnostic accuracy of semiquantitative analysis of visually equivocal WBC scans for diagnosing...
Paul Bosch, Frank F. A. IJpma, Geertje A. M. Govaert, Inge H. F. Reininga, Jean-Paul P. M. de Vries, Andor W. J. M. Glaudemans
Long axial field of view PET scanners: a road map to implementation and new possibilities
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-021-05461-6
document
In this contribution, several opportunities and challenges for long axial field of view (LAFOV) PET are described. It is an anthology in which the main issues have been highlighted. A consolidated overview of the camera system implementation, business and financial plan, opportunities and challenges is provided. What the nuclear medicine and molecular imaging community can expect from these new PET/CT scanners is the delivery of more comprehensive information to the clinicians for advancing diagnosis, therapy evaluation and clinical research.
Interleukin-2 PET imaging in patients with metastatic melanoma before and during immune checkpoint inhibitor therapy
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-021-05407-y
document
PURPOSE: Immune checkpoint inhibitors can induce a T cell-mediated anti-tumor immune response in patients with melanoma. Visualizing T cell activity using positron emission tomography (PET) might allow early insight into treatment efficacy. Activated tumor-infiltrating T cells express the high-affinity interleukin-2 receptor (IL-2R). Therefore, we performed a pilot study, using fluorine-18-labeled IL-2 ([18F]FB-IL2 PET), to evaluate whether a treatment-induced immune response can be detected. METHODS: Patients with metastatic melanoma received ~ 200 MBq [18F]FB-IL2 intravenously, followed by a PET/CT scan before and during immune checkpoint inhibitor therapy. [18F]FB-IL2 uptake...
Radionuclide Imaging of Invasive Fungal Disease in Immunocompromised Hosts
Published in: Diagnostics
Access to document
10.3390/diagnostics11112057
document
Invasive fungal disease (IFD) leads to increased mortality, morbidity, and costs of treatment in patients with immunosuppressive conditions. The definitive diagnosis of IFD relies on the isolation of the causative fungal agents through microscopy, culture, or nucleic acid testing in tissue samples obtained from the sites of the disease. Biopsy is not always feasible or safe to be undertaken in immunocompromised hosts at risk of IFD. Noninvasive diagnostic techniques are, therefore, needed for the diagnosis and treatment response assessment of IFD. The available techniques that identify fungal-specific antigens...
Ismaheel O Lawal, Kgomotso M G Mokoala, Mankgopo M Kgatle, Rudi A J O Dierckx, Andor W J M Glaudemans, Mike M Sathekge, Alfred O Ankrah