Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Analyzing the Estrogen Receptor Status of Liver Metastases with [F-18]-FES-PET in Patients with Breast Cancer
Published in: Diagnostics
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10.3390/diagnostics11112019
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BACKGROUND: Positron emission tomography (PET) with 16α-[18F]-fluoro-17β-estradiol ([18F]-FES) can visualize estrogen receptor (ER) expression, but it is challenging to determine the ER status of liver metastases, due to high physiological [18F]-FES uptake. We evaluated whether [18F]-FES-PET can be used to determine the ER status of liver metastases, using corresponding liver biopsies as the gold standard. METHODS: Patients with metastatic breast cancer (n = 23) were included if they had undergone a [18F]-FES-PET, liver metastasis biopsy, CT-scan, and [18F]-FDG-PET. [18F]-FES-PET scans were assessed by visual and quantitative analysis, tracer...
Jorianne Boers, Naila Loudini, Robbert J de Haas, Antoon T M Willemsen, Bert van der Vegt, Elisabeth G E de Vries, Geke A P Hospers, Carolina P Schröder, Andor W J M Glaudemans, Erik F J de Vries
Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies
Published in: Diagnostics
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10.3390/diagnostics11111986
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The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using mean, maximum, and peak standardized uptake values corrected for body weight (SUVs) and lean body mass (SULs) in 41 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans of LVV patients. Sex influence on the blood pool activity was assessed with t-tests,...
Limitations and Pitfalls of FDG-PET/CT in Infection and Inflammation
Published in: Seminars in Nuclear Medicine
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10.1053/j.semnuclmed.2021.06.008
document
White blood cells activated by either a pathogen or as part of a systemic inflammatory disease are characterized by high energy consumption and are therefore taking up the glucose analogue PET tracer FDG avidly. It is therefore not surprising that a steadily growing body of research and clinical reports now supports the use of FDG PET/CT to diagnose a wide range of patients with non-oncological diseases. However, using FDG PET/CT in patients with infectious or inflammatory diseases has some limitations and potential pitfalls that are not necessarily as...
Jordy P Pijl, Pieter H Nienhuis, Thomas C Kwee, Andor W J M Glaudemans, Riemer H J A Slart, Lars C Gormsen
Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-021-05362-8
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PURPOSE: Monitoring disease activity in patients with large vessel vasculitis (LVV) can be challenging. [18F]FDG-PET/CT is increasingly used to evaluate treatment response in LVV. In this systematic review and meta-analysis, we aimed to summarize the current evidence on the value of [18F]FDG-PET/CT for treatment monitoring in LVV. METHODS: PubMed/MEDLINE and the Cochrane library database were searched from inception through October 21, 2020. Studies containing patients with LVV (i.e. giant cell arteritis, Takayasu arteritis and isolated aortitis) that received treatment and underwent [18F]FDG-PET/CT were included. Screening, full-text review and...
K. S. M. van der Geest, G. Treglia, A. W. J. M. Glaudemans, E. Brouwer, M. Sandovici, F. Jamar, O. Gheysens, R. H. J. A. Slart
Study on intracranial meningioma using PET ligand investigation during follow-up over years (SIMPLIFY)
Published in: Neuroradiology
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10.1007/s00234-021-02683-1
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Purpose Radiologic follow-up of patients with a meningioma at the skull base or near the venous sinuses with magnetic resonance imaging (MRI) after stereotactic radiotherapy (SRT) and neurosurgical resection(s) can be difficult to interpret. This study evaluates the addition of C-11-methionine positron emission tomography (MET-PET) to the regular MRI follow-up. Methods This prospective pilot study included patients with predominantly WHO grade I meningiomas at the skull base or near large vascular structures. Previous SRT was part of their oncological treatment. A MET-PET in adjunct to their regular MRI...
Hanne-Rinck Jeltema, Marnix R Jansen, Adriaan R E Potgieser, Antoinette D I van Asselt, Mart A A M Heesters, Anouk van de Hoorn, Andor W J M Glaudemans, J Marc C van Dijk