Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Editorial: Functional Imaging of Inflammation and Infection
Published in: Frontiers in Medicine
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10.3389/fmed.2022.925635
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Ismaheel O. Lawal, Olivier Gheysens, Mike M. Sathekge, Andor W.J.M. Glaudemans
Identification of the estrogen receptor beta as a possible new tamoxifen-sensitive target in diffuse large B-cell lymphoma
Published in: Blood cancer journal
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10.1038/s41408-022-00631-7
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Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype. Despite the proven efficacy of combined immunochemotherapy (R-CHOP) in the majority of patients, ~40% of DLBCL patients do not respond or will relapse and consequently have a very poor prognosis. The development of targeted therapies has not improved patient survival, underscoring the need for new treatment approaches. Using an unbiased genome-wide CD20 guilt-by-association approach in more than 1800 DLBCL patients, we previously identified the estrogen receptor beta (ERβ) as a new target in DLBCL. Here, we demonstrate...
Myra Langendonk, Mathilde R W de Jong, Nienke Smit, Jonas Seiler, Bart Reitsma, Emanuele Ammatuna, Andor W J M Glaudemans, Anke van den Berg, Gerwin A Huls, Lydia Visser, Tom van Meerten
Comparison and validation of FDG-PET/CT scores for polymyalgia rheumatica
Published in: Rheumatology
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10.1093/rheumatology/keab483
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OBJECTIVES: To compare and validate the diagnostic accuracy of FDG-PET/CT scores for polymyalgia rheumatica (PMR); and to explore their relationship with clinical factors. METHODS: This retrospective study included 39 consecutive patients diagnosed with PMR and 19 PMR comparators. The final clinical diagnosis was established after 6 months follow-up. Patients underwent FDG-PET/CT prior to glucocorticoid treatment. Visual grading of FDG uptake was performed at 30 anatomic sites. Three FDG-PET/CT scores (one by Henckaerts, two by Sondag) and two algorithms (by Flaus and Owen) were investigated. Receiver operating characteristic (ROC)...
Validation and test-retest repeatability performance of parametric methods for [11C]UCB-J PET
Published in: EJNMMI Research
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10.1186/s13550-021-00874-8
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[11C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [11C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main objective of this study was to evaluate the quantitative accuracy and the 28-day test-retest repeatability (TRT) of various parametric quantitative methods for dynamic [11C]UCB-J studies in Alzheimer’s disease (AD) patients and healthy controls (HC). Eight HCs and seven AD patients underwent two 60-min dynamic [11C]UCB-J PET scans with arterial sampling over a 28-day interval. Several plasma-input based and reference-region based...
Hayel Tuncel, Ronald Boellaard, Emma M Coomans, Marijke den Hollander-Meeuwsen, Erik F J de Vries, Andor W J M Glaudemans, Paula Kopschina Feltes, David Vállez García, Sander C J Verfaillie, Emma E Wolters, Steven P Sweeney, J Michael Ryan, Magnus Ivarsson, Berkley A Lynch, Patrick Schober, Philip Scheltens, Robert C Schuit, Albert D Windhorst, Peter P De Deyn, Bart N M van BerckelSandeep S V Golla
Nuclear imaging does not have clear added value in patients with low a priori chance of periprosthetic joint infection. A retrospective single-center experience
Published in: Journal of bone and joint infection
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10.5194/jbji-7-1-2022
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Background: A low-grade periprosthetic joint infection (PJI) may present without specific symptoms, and its diagnosis remains a challenge. Three-phase bone scintigraphy (TPBS) and white blood cell (WBC) scintigraphy are incorporated into recently introduced diagnostic criteria for PJI, but their exact value in diagnosing low-grade PJI in patients with nonspecific symptoms remains unclear. Methods: In this retrospective study, we evaluated patients with a prosthetic joint of the hip or knee who underwent TPBS and/or WBC scintigraphy between 2009 and 2016 because of nonspecific symptoms. We reviewed and calculated diagnostic...
Karsten D Ottink, Stefan J Gelderman, Marjan Wouthuyzen-Bakker, Joris J W Ploegmakers, Andor W J M Glaudemans, Paul C Jutte