Lydia Visser
PhD
My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.
Proteomics Based Identification of Proteins with Deregulated Expression in B Cell Lymphomas
Published in: PLoS ONE
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10.1371/journal.pone.0146624
document
Follicular lymphoma and diffuse large B cell lymphomas comprise the main entities of adult B cell malignancies. Although multiple disease driving gene aberrations have been identified by gene expression and genomic studies, only a few studies focused at the protein level. We applied 2 dimensional gel electrophoresis to compare seven GC B cell non Hodgkin lymphoma (NHL) cell lines with a lymphoblastoid cell line (LCL). An average of 130 spots were at least two folds different in intensity between NHL cell lines and the LCL. We selected approximately...
Rui Wu, Marcel Nijland, Bea Rutgers, Rianne Veenstra, Myra Langendonk, Lotte E. van der Meeren, Philip M. Kluin, Guanwu Li, Arjan Diepstra, Jen-Fu Chiu, Anke van den Berg, Lydia Visser
Mutations in CD58 and Other Immune System Related Genes in Hodgkin Lymphoma
Mir-155 Enhances B-Cell Lymphoma Growth By Targeting TBRG1
Joost Kluiver, Izabella Slezak, Melanie Winkle, Lydia Visser, Arjan Diepstra, Bart-Jan Kroesen, Anke Van den Berg
Microenvironment, crosstalk, and immune escape mechanisms
Published in: Hematologic Malignancies
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10.1007/978-3-319-12505-3_4
Paediatric nodal marginal zone B cell lymphadenopathy of the neck: a Haemophilus influenzae driven immune disorder?
Published in: The Journal of Pathology
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10.1002/path.4524
Many hyperplasias and lymphomas of marginal zone B-cells are associated with infection. We identified 6 children and 1 adolescent with cervical lymphadenopathy showing a prominent polyclonal nodal marginal zone hyperplasia (pNMZH) and 4 adolescents with monoclonal paediatric nodal marginal zone lymphoma (pNMZL). The clonality status was assessed using BIOMED 2-IG PCR analysis. H. influenzae was identified in all 6 pNMZH that could be tested by direct culture (N = 3) or a very sensitive PCR for the H. influenzae gyrase gene in frozen materials (N = 5). H. influenzae was not detected...
Philip M. Kluin, Anton W. Langerak, Jannetta Beverdam-Vincent, Willemina R. R. Geurts-Giele, Lydia Visser, Bea Rutgers, Ed Schuuring, Joop Van Baarlen, King H. Lam, Kees Seldenrijk, Robby E. Kibbelaar, Peter de Wit, Arjan Diepstra, Stefano Rosati, Max M. van Noesel, C. Michel Zwaan, Jarmo C. B. Hunting, Mels Hoogendoorn, Ellen J. van der Gaag, Joost W. J. van EsserEveline de Bont, Hanneke C. Kluin-Nelemans, Rik H. Winter, Jerome R. Lo ten Foe, Adri G. M. van der Zanden