Lydia Visser
PhD
My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
Published in: Nature Communications
Access to document
10.1038/ncomms4856
document
Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR) = 0.81, 95% confidence interval (95% CI) = 0.76-0.86, P-combined 3.5 x...
W. Cozen, M. N. Timofeeva, D. Li, A. Diepstra, D. Hazelett, M. Delahaye-Sourdeix, C. K. Edlund, L. Franke, K. Rostgaard, D. J. Van Den Berg, V. K. Cortessis, K. E. Smedby, S. L. Glaser, H. -J. Westra, L. L. Robison, T. M. Mack, H. Ghesquieres, A. E. Hwang, A. Nieters, S. de SanjoseT. Lightfoot, N. Becker, M. Maynadie, L. Foretova, E. Roman, Y. Benavente, K. A. Rand, B. N. Nathwani, B. Glimelius, A. Staines, P. Boffetta, B. K. Link, L. Kiemeney, S. M. Ansell, S. Bhatia, L. C. Strong, P. Galan, L. Vatten, T. M. Habermann, E. J. Duell, A. Lake, R. N. Veenstra, Lydia Visser, Y. Liu, K. Y. Urayama, D. Montgomery, V. Gaborieau, L. M. Weiss, G. Byrnes, M. Lathrop, P. Cocco, T. Best, A. D. Skol, H. -O. Adami, M. Melbye, J. R. Cerhan, A. Gallagher, G. M. Taylor, S. L. Slager, P. Brennan, G. A. Coetzee, D. V. Conti, K. Onel, R. F. Jarrett, H. Hjalgrim, A. van den Berg, J. D. Mckay
Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn’s disease
Published in: Science Translational Medicine
Access to document
10.1126/scitranslmed.3006763
In inflammatory bowel disease (IBD), large areas of apparently healthy mucosa lie adjacent to ulcerated intestine. Knowledge of the mechanisms that maintain remission in an otherwise inflamed intestine could provide important clues to the pathogenesis of this disease and provide rationale for clinical treatment strategies. We used kinome profiling to generate comprehensive descriptions of signal transduction pathways in inflamed and noninflamed colonic mucosa in a cohort of IBD patients, and compared the results to non-IBD controls. We observed that p21Rac1 guanosine triphosphatase (GTPase) signaling was strongly suppressed in...
Kaushal Parikh, Lu Zhou, Rajesh Somasundaram, Gwenny M Fuhler, J Jasper Deuring, Tjasso Blokzijl, Anouk Regeling, Ernst J Kuipers, Rinse K Weersma, Veerle J Nuij, Maria Alves, Lauran Vogelaar, Lydia Visser, Colin de Haar, Kausilia K Krishnadath, C Janneke van der Woude, Gerard Dijkstra, Klaas Nico Faber, Maikel P Peppelenbosch
The microenvironment in classical Hodgkin lymphoma: an actively shaped and essential tumor component
Published in: Seminars in cancer biology
Access to document
10.1016/j.semcancer.2013.07.002
Classical Hodgkin lymphoma (cHL) is characterized by a minority of tumor cells derived from germinal center B-cells and a vast majority of non-malignant reactive cells. The tumor cells show a loss of B-cell phenotype including lack of the B-cell receptor, which makes the tumor cells vulnerable to apoptosis. To overcome this threat, tumor cells and their precursors depend on anti-apoptotic and growth stimulating factors that are obtained via triggering of multiple membrane receptors. In addition, tumor cells shape the environment by producing a wide variety of chemokines and...
Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma
Published in: PLoS ONE
Access to document
10.1371/journal.pone.0087474
document
The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL. IGF-1R was overexpressed in 55% (44/80) of cHL patients. Phosphorylated IGF-1R was detectable in a minority of the IGF-1R positive tumor cells. The overall survival (OS, 98%) and 5-year progression-free survival (PFS, 93%) was significantly higher in IGF-1R positive cHL patients compared to IGF-1R negative patients (OS 83%,...
Zheng Liang, Arjan Diepstra, Chuanhui Xu, Gustaaf van Imhoff, Wouter Plattel, Anke Van Den Berg, Lydia Visser
Long Non-Coding RNAs Are Commonly Deregulated In Hodgkin Lymphoma
Masoumeh Tayari, Klaas Kok, Gertrud Kortman, Jantine Sietzema, Debora de Jang, Martijn Terpstra, Lydia Visser, Arjan Diepstra, Joost Kluiver, Anke Van den Berg