Arjan Diepstra
dr.
As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.
Latest publications
(216)
Activities
(38)
Press/Media
(7)
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(4)
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(1)
Supervised work
(12)
Mutations in CD58 and Other Immune System Related Genes in Hodgkin Lymphoma
Mir-155 Enhances B-Cell Lymphoma Growth By Targeting TBRG1
Joost Kluiver, Izabella Slezak, Melanie Winkle, Lydia Visser, Arjan Diepstra, Bart-Jan Kroesen, Anke Van den Berg
Microenvironment, crosstalk, and immune escape mechanisms
Published in: Hematologic Malignancies
Access to document
10.1007/978-3-319-12505-3_4
A Novel Risk Locus at 6p21.3 for Epstein-Barr Virus-Positive Hodgkin Lymphoma
Published in: Cancer Epidemiology, Biomarkers & Prevention
Access to document
10.1158/1055-9965.EPI-15-0534
Background: A proportion of the genetic variants involved in susceptibility to Hodgkin lymphoma differ by the tumor’s Epstein-Barr virus (EBV) status, particularly within the MHC region. Methods: We have conducted an SNP imputation study of the MHC region, considering tumor EBV status in 1,200 classical Hodgkin lymphoma (cHL) cases and 5,726 control subjects of European origin. Notable findings were genotyped in an independent study population of 468 cHL cases and 551 controls. Results: We identified and subsequently replicated a novel association between a common genetic variant rs6457715 and...
Manon Delahaye-Sourdeix, Kevin Y. Urayama, Valerie Gaborieau, Rianne Veenstra, Matthieu Foll, Amelie Chabrier, Yolanda Benavente, Alexandra Nieters, Nikolaus Becker, Lenka Foretova, Marc Maynadie, Anthony Staines, Karin Ekstrom Smedby, Ingrid Glimelius, Tracy Lightfoot, Pierluigi Cocco, Pilar Galan, Lars J. Vatten, Eric J. Duell, Lambertus KiemeneyEve Roman, Silvia de Sanjose, Mark Lathrop, Mads Melbye, Paul Brennan, Arjan Diepstra, Anke Van den Berg, Henrik Hjalgrim, Ruth F. Jarrett, James D. McKay
Paediatric nodal marginal zone B cell lymphadenopathy of the neck: a Haemophilus influenzae driven immune disorder?
Published in: The Journal of Pathology
Access to document
10.1002/path.4524
Many hyperplasias and lymphomas of marginal zone B-cells are associated with infection. We identified 6 children and 1 adolescent with cervical lymphadenopathy showing a prominent polyclonal nodal marginal zone hyperplasia (pNMZH) and 4 adolescents with monoclonal paediatric nodal marginal zone lymphoma (pNMZL). The clonality status was assessed using BIOMED 2-IG PCR analysis. H. influenzae was identified in all 6 pNMZH that could be tested by direct culture (N = 3) or a very sensitive PCR for the H. influenzae gyrase gene in frozen materials (N = 5). H. influenzae was not detected...
Philip M. Kluin, Anton W. Langerak, Jannetta Beverdam-Vincent, Willemina R. R. Geurts-Giele, Lydia Visser, Bea Rutgers, Ed Schuuring, Joop Van Baarlen, King H. Lam, Kees Seldenrijk, Robby E. Kibbelaar, Peter de Wit, Arjan Diepstra, Stefano Rosati, Max M. van Noesel, C. Michel Zwaan, Jarmo C. B. Hunting, Mels Hoogendoorn, Ellen J. van der Gaag, Joost W. J. van EsserEveline de Bont, Hanneke C. Kluin-Nelemans, Rik H. Winter, Jerome R. Lo ten Foe, Adri G. M. van der Zanden