Arjan Diepstra
dr.
As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.
Latest publications
(215)
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(38)
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(6)
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(1)
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(11)
Epstein-Barr virus, the germinal centre and the development of Hodgkin’s lymphoma
Published in: The Journal of general virology
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10.1099/vir.0.066712-0
The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin’s lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the...
Ghada Mohamed, Katerina Vrzalikova, Fathima Zumla Cader, Martina Vockerodt, Eszter Nagy, Patrik Flodr, Lee-Fah Yap, Arjan Diepstra, Philip M. Kluin, Stefano Rosati, Paul Murray
Toll-like receptors in the pathogenesis of human B cell malignancies
Published in: Journal of Hematology & Oncology
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10.1186/s13045-014-0057-5
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Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may be involved in the pathogenesis of B-cell lymphomas. Accumulating studies show differential expression in this heterogeneous group of cancers. Stimulation with TLR specific ligands, or agonists of their ligands, leads to aberrant responses in the malignant B-cells. According to current data, TLRs can be implicated in malignant transformation, tumor progression and immune evasion processes. Most of the studies focused on multiple myeloma and chronic lymphocytic leukemia, but in the last decade the putative role...
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
Published in: Nature Communications
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10.1038/ncomms4856
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Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR) = 0.81, 95% confidence interval (95% CI) = 0.76-0.86, P-combined 3.5 x...
W. Cozen, M. N. Timofeeva, D. Li, A. Diepstra, D. Hazelett, M. Delahaye-Sourdeix, C. K. Edlund, L. Franke, K. Rostgaard, D. J. Van Den Berg, V. K. Cortessis, K. E. Smedby, S. L. Glaser, H. -J. Westra, L. L. Robison, T. M. Mack, H. Ghesquieres, A. E. Hwang, A. Nieters, S. de SanjoseT. Lightfoot, N. Becker, M. Maynadie, L. Foretova, E. Roman, Y. Benavente, K. A. Rand, B. N. Nathwani, B. Glimelius, A. Staines, P. Boffetta, B. K. Link, L. Kiemeney, S. M. Ansell, S. Bhatia, L. C. Strong, P. Galan, L. Vatten, T. M. Habermann, E. J. Duell, A. Lake, R. N. Veenstra, Lydia Visser, Y. Liu, K. Y. Urayama, D. Montgomery, V. Gaborieau, L. M. Weiss, G. Byrnes, M. Lathrop, P. Cocco, T. Best, A. D. Skol, H. -O. Adami, M. Melbye, J. R. Cerhan, A. Gallagher, G. M. Taylor, S. L. Slager, P. Brennan, G. A. Coetzee, D. V. Conti, K. Onel, R. F. Jarrett, H. Hjalgrim, A. van den Berg, J. D. Mckay
The renal angiopoietin/Tie2 system in lethal human sepsis
Published in: Critical care (London, England)
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10.1186/cc13806
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Sepsis-induced multi-organ dysfunction syndrome (MODS) still has a high mortality. Improvements await a better understanding of the pathophysiological mechanisms. The angiopoietin (Ang)1/2 and Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2) ligand/receptor system is an important regulator of endothelial cell responses to severe insults. Plasma Ang2 levels are prognostic in sepsis, but data on Ang/Tie responses in organs in humans are lacking.. We hypothesized that, in kidneys of patients who died of sepsis with acute kidney injury (AKI), the Ang/Tie signaling system is changed...
The microenvironment in classical Hodgkin lymphoma: an actively shaped and essential tumor component
Published in: Seminars in cancer biology
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10.1016/j.semcancer.2013.07.002
Classical Hodgkin lymphoma (cHL) is characterized by a minority of tumor cells derived from germinal center B-cells and a vast majority of non-malignant reactive cells. The tumor cells show a loss of B-cell phenotype including lack of the B-cell receptor, which makes the tumor cells vulnerable to apoptosis. To overcome this threat, tumor cells and their precursors depend on anti-apoptotic and growth stimulating factors that are obtained via triggering of multiple membrane receptors. In addition, tumor cells shape the environment by producing a wide variety of chemokines and...