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Arjan Diepstra
dr.

As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.

Symptom Burden and Patient-Reported Outcomes in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Studies
Published in: Kidney Medicine
Access to document 10.1016/j.xkme.2025.101168 document
Rationale & Objective: A multitude of symptoms may contribute to low health-related quality of life (HRQoL) in kidney transplant recipients (KTR). We aimed to identify the most occurring and distressing symptoms, to explore potential determinants of symptom burden, and to examine associations with patient-reported outcomes in KTR. Study Design: A cross-sectional retrospective patient-reported outcome measures study. Setting & Participants: Stable KTR ≥1 year after transplantation participating in the TransplantLines Biobank and Cohort Studies. Predictors: Clinical variables, including sex, age, and time after transplantation. Outcomes: Symptom occurrence/distress/burden, medication adherence,...
TransplantLines Investigators, Niels L. Riemersma, Tim J. Knobbe, Daan Kremer, Svea Nolte, Ute Bültmann, Coby Annema, Naser B.N. Shehab, Michele F. Eisenga, Stefan P. Berger, Stephan J.L. Bakker, G. J. Nieuwenhuijs
Superior survival in diffuse large B cell lymphoma of the bone with immune rich tumor microenvironment
Published in: Blood cancer journal
Access to document 10.1038/s41408-025-01291-z document
With tumor genomic and gene-expression profiling (GEP), this study investigated the immune-molecular signatures of a unique cohort of diffuse large B-cell lymphoma of the bone (bone-DLBCL), including primary bone (PB-DLBCL, n = 52) and polyostotic-DLBCL (n = 20), in comparison to nodal DLBCLs with germinal center B-cell (GCB) phenotype (nodal-DLBCL-GCB, n = 34). PB-DLBCL and polyostotic-DLBCL shared similar genomic profiles and transcriptomic signatures, justifying their collective analysis as bone-DLBCL. Differential incidences of EZH2, HIST1H1E, and MYC aberrations (p < 0.05) confirmed the distinct oncogenic evolution between bone-DLBCL and...
Ruben A.L. de Groen, Fleur A. de Groot, Stefan Böhringer, Esther J. Kret, Lorraine M. de Haan, Troy Noordenbos, Susan Blommers, Romée E.W. Jansen, Tom van Wezel, Ronald van Eijk, Richard Raghoo, Dina Ruano, Liane te Boome, Valeska Terpstra, Henriette Levenga, Els Ahsmann, Eduardus F.M. Posthuma, Isabelle Focke-Snieders, Lizan Hardi, Wietske C.E. den HartogAnke van den Berg, Pim Mutsaers, King Lam, Marjolein W.M. van der Poel, Myrurgia Abdul Hamid, F. J.Sherida H. Woei-A-Jin, Ann Janssens, Thomas Tousseyn, Judith V.M.G. Bovée, Lianne Koens, Arjan Diepstra, Arjen H.G. Cleven, Marie José Kersten, Patty M. Jansen, Hendrik Veelken, Marcel Nijland, Tim J.A. Dekker, Joost S.P. Vermaat
MATRix and HD-MTX/IFO/DEP treatment and autologous stem cell transplantation in secondary central nervous system lymphoma: a Dutch retrospective analysis
Published in: Haematologica
Access to document 10.3324/haematol.2025.287485 document
Fleur A De Groot, Floriske G Stedema, Esther J Kret, Lorraine M De Haan, Patty M Jansen, Stefan Böhringer, Arjan Diepstra, Marjolein W M Van der Poel, Myrurgia Abdul Hamid, Liane C J Te Boome, Valeska Terpstra, Mirian Brink, Hendrik Veelken, Ruben A L De Groen, Tim J A Dekker, Marcel Nijland, Joost S P Vermaat
Posttransplant Dynamics of Serum T50 and Coronary Artery Calcium Scores Among Kidney Transplant Recipients
Published in: Kidney International Reports
Access to document 10.1016/j.ekir.2025.08.009 document
TransplantLines Investigators, Amarens van der Vaart, Daan Kremer, Edward R. Smith, Rozemarijn Vliegenthart, Andreas Pasch, Jan-Luuk Hillebrands, Jeroen H.F. de Baaij, Stephan J.L. Bakker, Martin H. de Borst, Charlotte A. Te Velde-Keyzer
Insights in Cellular and Molecular Signatures of the Small Intestinal Graft Posttransplantation: Successful, Recovered, and Rejected – A Case Series
Published in: Transplantation
Access to document 10.1097/TP.0000000000005411 document
BACKGROUND: Intestinal transplantation is the treatment for patients with irreversible intestinal failure and complications of parenteral nutrition. Five-year graft survival is only 56%, possibly due to an imbalance in immunosuppression, aiming to prevent rejection while maintaining protection against pathogens. Studying the graft’s mucosal cell populations and regulation of donor and recipient cells posttransplantation offers a unique opportunity to address this (im)balance leading to rejection. METHODS: We performed single-cell mRNA sequencing of longitudinally sampled ileal graft biopsies from surgery up to 6 mo after transplantation, althrough the TransplantLines Biobank...
TransplantLines Investigators, Naomi Karmi, Roy Oelen, Emilia Bigaeva, Sofie De Jong, Jan Willem Haveman, Frans Van Der Heide, Marcela A. Hermoso, Monique G.P. Van Der Wijst, Gursah Kats-Ugurlu, Rinse K. Weersma, Eleonora A.M. Festen, Werna T.C. Uniken Venema, Gerard Dijkstra