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Arjan Diepstra
dr.

As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.

Plasma trimethylamine N-oxide concentration and all-cause mortality in kidney transplant recipients
Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Access to document 10.1093/ndt/gfaf071 document
BACKGROUND AND HYPOTHESIS: Trimethylamine N-oxide (TMAO) is a pro-atherosclerotic molecule produced by intestinal microbiome. TMAO has been linked to increased mortality risk in chronic kidney disease, but its effect in kidney transplant recipients (KTR) is unclear. We investigated the pre-post-transplantation plasma TMAO change, and the association of post-transplantation plasma TMAO with all-cause mortality in KTR. METHODS: This prospective study included two cohorts. Cohort A comprised 623 KTR from the TransplantLines Cohort and Biobank Study (ClinicalTrials.gov: NCT03272841), assessed pre-transplantation and at 3, 6, 12, and 24 months post-transplantation. Cohort...
TransplantLines Investigators, Manuela Yepes-Calderón, Fernando Martín Del Campo Sanchez, Daan Kremer, Tim J. Knobbe, Antonio W. Gomes Neto, Margery A. Connelley, Robin P.F. Dullaart, Eva Corpeleijn, Martin H. De Borst, Stephan J.L. Bakker
Serum TARC: a biomarker for early detection or exclusion of relapse in classic Hodgkin Lymphoma
Published in: Blood Advances
Access to document 10.1182/bloodadvances.2025015837 document
Sophie A Teesink, Lydia Visser, Marcel Nijland, Kylie Keijzer, Anne Gh Niezink, Bart-Jan Kroesen, Anke van den Berg, Arjan Diepstra, Wouter J Plattel
IgM Immunohistochemical Expression is a Potential Risk Factor for Extracutaneous Dissemination in Patients With Primary Cutaneous Follicle Center Lymphoma
Published in: American Journal of Surgical Pathology
Access to document 10.1097/PAS.0000000000002436 document
Primary cutaneous follicle center lymphoma (PCFCL) is a type of cutaneous B-cell lymphoma with an indolent behavior and a 5-year disease-specific survival of 95%. Given the difficulty of identifying patients at risk for developing extracutaneous dissemination (ECD), this study aimed to identify predictors in the clinical presentation, histopathology, immune phenotype, and genetic profile of PCFCL patients by comparing those who developed ECD with those whose disease remained skin limited (SL) during follow-up. After review of clinical data and histopathology, a total of 13 ECD-PCFCL patients and 15 SL-PCFCL...
Anne M R Schrader, Ruben A L de Groen, Rein Willemze, Patty M Jansen, Koen D Quint, Tom van Wezel, Ronald van Eijk, Dina Ruano, Cornelis P Tensen, Arjan Diepstra, Anke van den Berg, Lianne Koens, Naomi Kakiailatu, Maarten H Vermeer, Joost S P Vermaat
Multi-Cohort High-Dimensional Proteomics Reveals Early Risk Markers for Lymphoid Cancer Subtypes
Access to document 10.21203/rs.3.rs-7400676/v1
This study aims to investigate the early stages of lymphoid malignancy pathogenesis and identify novel pre-diagnostic proteomic markers for lymphoma. Using the SomaScan-7K platform, we analyzed 6,412 unique plasma proteins in a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, comprising 4,565 participants (484 incident lymphoid malignancy cases, median follow-up 9 years). We identified over 500 unique protein-lymphoid malignancy associations. Enriched pathways included viral protein interactions, cytokine signaling, B-cell receptor signaling, and NF-κB activation, reflecting key mechanisms in lymphoma pathogenesis. Cross-cohort validation...
P Martijn Kolijn, Karl Smith-Byrne, Vernon Burk, Vivian Viallon, Matthew A Lee, Keren Papier, Ziqiao Wang, Anton W Langerak, Florentin Späth, Arjan Diepstra, Christina M Lill, Raul Zamora-Ros, Alessandra Macciotta, Amaia Aizpurua, Rosario Tumino, Nilanjan Chatterjee, Ruth C Travis, Marc J Gunter, Elizabeth A Platz, Elio RiboliJames McKay, Roel C H Vermeulen
Posttransplant Dynamics of Serum T50 and Coronary Artery Calcium Scores Among Kidney Transplant Recipients
Published in: Kidney International Reports
Access to document 10.1016/j.ekir.2025.08.009 document
TransplantLines Investigators, Amarens van der Vaart, Daan Kremer, Edward R. Smith, Rozemarijn Vliegenthart, Andreas Pasch, Jan-Luuk Hillebrands, Jeroen H.F. de Baaij, Stephan J.L. Bakker, Martin H. de Borst, Charlotte A. Te Velde-Keyzer