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Arjan Diepstra
dr.

As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.

Urinary endotrophin as a biomarker for T cell-mediated rejection-associated fibrogenesis in kidney transplant recipients
Published in: Clinical Kidney Journal
Access to document 10.1093/ckj/sfaf301 document
BACKGROUND: Endotrophin, a C-terminal pro-collagen type VIα3 fragment, has been shown to correlate with kidney interstitial fibrosis, kidney outcome measures and survival in various kidney diseases and kidney transplantation. In this study we investigated whether endotrophin is associated with fibrogenesis in T cell-mediated rejection (TCMR), allowing its use as a non-invasive biomarker. METHOD: Plasma endotrophin and urinary endotrophin (indexed for creatinine) were measured in samples from a cross-sectional study among kidney transplant recipients (KTRs) who underwent indication biopsy after transplantation and enrolled in TransplantLines Biobank and Cohort Study....
Firas F. Alkaff, Daan Kremer, Daniel G.K. Rasmussen, Nadja Sparding, Federica Genovese, Morten Karsdal, Wendy A. Dam, Marius C. Van Den Heuvel, Martin Tepel, Olivier Thaunat, Coby Annema, Stephan J.L. Bakker, Stefan P. Berger, Hans Blokzijl, Frank A.J.A. Bodewes, Marieke T. De Boer, Kevin Damman, Martin H. De Borst, Arjan Diepstra, Gerard DijkstraCaecilia S.E. Doorenbos, Rianne M. Douwes, Michele F. Eisenga, Michiel E. Erasmus, C. Tji Gan, Antonio W. Gomes Neto, Eelko Hak, Bouke G. Hepkema, Jip Jonker, Frank Klont, Tim J. Knobbe, Daan Kremer, Henri G.D. Leuvenink, Willem S. Lexmond, Vincent E. De Meijer, Hubert G.M. Niesters, Gertrude J. Nieuwenhuijs-Moeke, L. Joost Van Pelt, Robert A. Pol, Anna M. Posthumus, Adelita V. Ranchor, Jan Stephan F. Sanders, Marion J. Siebelink, Riemer J.H.J.A. Slart, J. Casper Swarte, Daan J. Touw, Marius C. Van Den Heuvel, Coretta Van Leer-Buter, Marco Van Londen, Charlotte A. Te Velde Keyzer, Erik A.M. Verschuuren, Michel J. Vos, Rinse K. Weersma, Stefan P. Berger, Jacob Van Den Born, Stephan J.L. Bakker
Multi-cohort high-dimensional proteomics reveals early risk markers for lymphoid cancer subtypes
Published in: Nature Communications
Access to document 10.1038/s41467-025-64534-4 document
This study aims to investigate the early stages of lymphoid malignancy pathogenesis and identify pre-diagnostic proteomic markers for lymphoma. Using the SomaScan-7K platform, we analyze 6412 unique plasma proteins in a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, comprising 4565 participants (484 incident lymphoid malignancy cases, median follow-up 9 years). We identify over 500 unique protein-lymphoid malignancy associations. Enriched pathways include viral protein interactions, cytokine signaling, B-cell receptor signaling, and NF-κB activation, reflecting key mechanisms in lymphoma pathogenesis. Cross-cohort validation of...
P Martijn Kolijn, Karl Smith-Byrne, Vernon Burk, Vivian Viallon, Matthew A Lee, Keren Papier, Ziqiao Wang, Anton W Langerak, Florentin Späth, Arjan Diepstra, Christina M Lill, Raul Zamora-Ros, Alessandra Macciotta, Amaia Aizpurua, Rosario Tumino, Nilanjan Chatterjee, Ruth C Travis, Marc J Gunter, Elizabeth A Platz, Elio RiboliJames McKay, Roel C H Vermeulen
Non-inferior outcome of abbreviated R-CHOP in patients with stage I primary testicular lymphoma
Published in: European Journal of Cancer
Access to document 10.1016/j.ejca.2025.115776 document
BACKGROUND: Patients with limited-stage primary testicular lymphoma (PTL) typically receive a multimodal regimen, including 6 cycles of R-CHOP, despite limited evidence. In low-risk diffuse large B-cell lymphoma, de-escalation to 4 R-CHOP cycles has proven non-inferior. It remains unclear whether similar de-escalation is feasible in PTL. METHODS: Patients aged ≥ 18 years with Ann Arbor stage I-II PTL diagnosed between 2014 and 2021 were identified in the Netherlands Cancer Registry. Patients receiving ≥ 3 R-CHOP cycles were included. Outcomes were 5-year progression-free survival (PFS), overall survival (OS), and cumulative incidence function...
Diana Al-Sarayfi, Johanna A A Bult, Ruben A L de Groen, Fleur A de Groot, Joost S P Vermaat, Djamilla Issa, Arjan Diepstra, Gerwin Huls, Mar Bellido, Wouter Plattel, Mirian Brink, Marcel Nijland
Programmed cell death-1 inhibition activates CD4 T cells in a novel in vitro model of Hodgkin lymphoma
Published in: British Journal of Haematology
Access to document 10.1111/bjh.70089 document
Rodrigo Martinez Alcala, Yajie Lei, Lydia Visser, Arjan Diepstra, Johanna Veldman
Plasma creatine, estimated intramuscular creatine and risk of mortality in stable kidney transplant recipients: Results from the TransplantLines biobank and cohort study
Published in: Clinical Nutrition ESPEN
Access to document 10.1016/j.clnesp.2025.07.030 document
BackgroundKidney transplant recipients (KTR) have reduced survival rates compared to the general population. Creatine is an endogenous nitrogenous organic acid, essential for energy metabolism. This study investigates sex stratified plasma creatine and estimated intramuscular creatine concentrations, and their transmembrane cellular gradient in relation to mortality in KTR. MethodsWe included 700 adult KTR with a functioning graft for at least one year post transplantation (TransplantLines Biobank and Cohort Study (NCT03272841)). Plasma creatine was measured using nuclear magnetic resonance spectroscopy. Intramuscular creatine was estimated using 24-h urinary creatinine excretion divided...
TransplantLines Investigators, Caecilia S.E. Doorenbos, Adrian Post, Yvonne van der Veen, Casper F.M. Franssen, Michele F. Eisenga, Gerjan Navis, Qinglin Wu, Margery A. Connelly, Stephan J.L. Bakker