Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Differential synovial fluid white blood cell count for the diagnosis of chronic peri-prosthetic joint infection – a systematic review and meta-analysis
Published in: Journal of bone and joint infection
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10.5194/jbji-10-165-2025
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Introduction: Peri-prosthetic joint infection (PJI) is a significant complication of arthroplasty, lacking a single gold standard diagnostic test. Synovial fluid white blood cell (WBC) count and polymorphonuclear neutrophil (PMN) proportion are widely used diagnostic tools, but their optimal cutoffs remain unclear, particularly for chronic PJI. Material and methods: This systematic review and meta-analysis included 74 studies published between 2000 and 2024. Data on diagnostic performance (sensitivity, specificity, and diagnostic odds ratios DORs) of WBC count and PMN proportions were analysed. Sub-group analyses and heterogeneity assessments were performed, and...
Leukocyte Count Synovial Fluid working group for the Unified PJI definition task force, Marta Sabater-Martos, Martin Clauss, Ana Ribau, Ricardo Sousa
Cardiovascular PET imaging of fibroblast activation A review of the current literature
Published in: Journal of Nuclear Cardiology
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10.1016/j.nuclcard.2024.102106
document
Fibrosis is one of the key healing responses to injury, especially within the heart where it helps to maintain structural integrity following acute insults such as myocardial infarction. However, if it becomes dysregulated then fibrosis can become maladaptive leading to adverse remodelling, impaired cardiac function and heart failure. Fibroblast activation protein is exclusively expressed by activated fibroblasts, the key effector cells of fibrogenesis, and has a unique extracellular domain that is an ideal ligand for novel molecular imaging probes. Fibroblast activation protein inhibitor (FAPI) radiotracers have been developed...
Krithika Loganath, Neil Craig, Anna Barton, Shruti Joshi, Constantinos Anagnostopoulos, Paola Anna Erba, Andor W J M Glaudemans, Antti Saraste, Jan Bucerius, Mark Lubberink, Olivier Gheysens, Ronny R Buechel, Gilbert Habib, Oliver Gaemperli, Alessia Gimelli, Fabien Hyafil, David E Newby, Riemer H J A Slart, Marc R Dweck
Evaluating Bone Healing with [18F]NaF PET/CT During Bone Segment Transport in Femoral Fracture Treatment.
Published in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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10.2967/jnumed.124.268913
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18F-FDG-PET/CT for polymyalgia rheumatica: agreement and diagnostic accuracy of routine PET scan report vs. standardized PMR PET scores
Published in: Frontiers in Nuclear Medicine
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10.3389/fnume.2025.1550881
document
BACKGROUND: 18F-FDG-PET/CT may reveal widespread inflammation of musculoskeletal structures in polymyalgia rheumatica (PMR). Currently, scans are subjectively analysed based on the overall gestalt of the scan. Standardized PET scores may potentially aid the interpretation of the scans for suspected PMR. Here, we compared the agreement and diagnostic accuracy of routine PET scan reports vs. the most validated PET scores for PMR. METHODS: 68 consecutive patients with suspected PMR (treatment-naïve, n = 29; already treated, n = 39) undergoing 18F-FDG-PET/CT were included. In glucocorticoid-treated patients, complete tapering was pursued prior to...
Kornelis S M van der Geest, Rob G J Grootelaar, Karin Bouwman, Maria Sandovici, Andor W J M Glaudemans, Elisabeth Brouwer, Riemer H J A Slart
Diagnostic Value of Increased [18F]FDG Uptake in Locoregional Lymph Nodes on PET/CT in Patients with Suspected Fracture-Related Infection
Published in: Diagnostics
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10.3390/diagnostics15050616
document
Background: Diagnosing fracture-related infection (FRI) without clinical confirmatory signs is challenging. [18F]FDG-PET/CT has been shown to have good diagnostic accuracy. However, direct interpretation criteria are lacking. The aim of this study was to assess the diagnostic value of increased FDG-uptake in locoregional lymph nodes on [18F]FDG-PET/CT in patients with suspected upper and lower extremity FRI. Methods: This was a retrospective cohort study of patients who underwent [18F]FDG-PET/CT for suspected extremity FRI in two tertiary referral centers between January 2011 and December 2023. The sensitivity, specificity and diagnostic value...
Paul Bosch, Andor W J M Glaudemans, Jean-Paul P M de Vries, Johannes H van Snick, Justin V C Lemans, Janna van den Kieboom, Monique G G Hobbelink, Geertje A M Govaert, Frank F A IJpma