I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists.
Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Ultrashort Oncologic Whole-Body [18F]FDG Patlak Imaging Using LAFOV PET.
Published in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Methods to shorten [ 18F]FDG Patlak PET imaging procedures ranging from 65-90 to 20-30 min after injection, using a population-averaged input function (PIF) scaled to patient-specific image-derived input function (IDIF) values, were recently evaluated. The aim of the present study was to explore the feasibility of ultrashort 10-min [ 18F]FDG Patlak imaging at 55-65 min after injection using a PIF combined with direct Patlak reconstructions to provide reliable quantitative accuracy of lung tumor uptake, compared with a full-duration 65-min acquisition using an IDIF. Methods: Patients underwent a 65-min dynamic PET...
[15O]H2O PET: Potential or Essential for Molecular Imaging?
Published in: Seminars in Nuclear Medicine
Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a wide range of diseases that are related to perfusion and oxygenation. Although water PET has a long history, its true potential has not made it into regular clinical practice. The article highlights the potential of water PET in molecular imaging and suggests its prospective role in becoming an essential tool for the 21st century precision medicine in different...
Riemer H J A Slart,
T Samara Martinez-Lucio,
Hendrikus H Boersma,
Ronald H Borra,
Bart Cornelissen,
Rudi A J O Dierckx,
Magdalena Dobrolinska,
Janine Doorduin, Paola A Erba,
Andor W J M Glaudemans,
Bruno Lima Giacobbo,
Gert Luurtsema,
Walter Noordzij,
Joyce van Sluis,
Charalampos Tsoumpas,
Adriaan A Lammertsma
Advances in PET Imaging of Large Vessel Vasculitis: An Update and Future Trends
Published in: Seminars in Nuclear Medicine
Systemic vasculitides are autoimmune diseases characterized by inflammation of blood vessels. They are categorized based on the size of the preferentially affected blood vessels: large-, medium-, and small-vessel vasculitides. The main forms of large-vessel vasculitis include giant cell arteritis (GCA) and Takayasu arteritis (TAK). Depending on the location of the affected vessels, various imaging modalities can be employed for diagnosis of large vessel vasculitis: ultrasonography (US), magnetic resonance angiography (MRA), computed tomography angiography (CTA), and [ 18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT). These imaging tools offer complementary information...
Towards molecular imaging-guided intervention theatres in oncology
Published in: European Journal of Nuclear Medicine and Molecular Imaging
11C-Methionine uptake in meningiomas after stereotactic radiotherapy.
Published in: Annals of Nuclear Medicine
OBJECTIVE: 11C-Methionine positron emission tomography (MET-PET) is used for stereotactic radiotherapy planning in meningioma patients. The role of MET-PET during subsequent follow-up (FU) is unclear. We analyzed the uptake of 11C-Methionine before and after stereotactic radiotherapy (SRT) in patients with a complex meningioma and investigated if there was a difference between patients with progressive disease (PD) and stable disease (SD) during FU. METHODS: This retrospective study investigates 62 MET-PETs in 29 complex meningioma patients. Standardized uptake value (SUV) max and SUV peak tumor-to-normal ratios (T/N-ratios) were calculated, comparing...