Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
How can children benefit from total-body PET?
Published in: British journal of radiology
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10.1093/bjr/tqaf242
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The introduction of long axial field-of-view (LAFOV) PET/CT scanners marks a major advancement in paediatric nuclear medicine. These systems provide greatly enhanced sensitivity, enabling superior image quality with reduced radiopharmaceutical doses and substantially shorter scan times. This is particularly advantageous in children, who are more radiosensitive and often struggle with prolonged procedures that may require sedation. LAFOV PET/CT allows whole-body imaging in a single bed position, reducing motion artefacts, improving patient comfort, and lessening procedural anxiety. Such benefits align with the ALARA (As Low As Reasonably Achievable) principle,...
Paul J H van Snick, Sasha O V Ivashchenko, Joyce van Sluis, Limme B de Langen, Georgie C van den Oever, Mostafa Roya, Andor W J M Glaudemans, Riemer H J A Slart
Clinical evaluation of dynamic [18F]FDG PET imaging to distinguish infection from inflammation in fracture-related infections.
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-025-07563-x
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BACKGROUND: Standard [ 18F]FDG PET/CT is widely used to detect infections, but is limited in differentiating bacterial infection from inflammation due to overlapping uptake patterns. This distinction is particularly challenging in fracture-related infection (FRI), due to multiple factors, including recent surgery, soft tissue injury, fracture healing, and surgical implants. Dynamic [ 18F]FDG imaging over time may overcome this limitation by capturing a rapid, sustained uptake seen in infections, driven by ongoing immune and microbial activity, as opposed to the potentially slower uptake in inflammation. This study investigates the...
N D van Rijsewijk, M Wouthuyzen-Bakker, J H van Snick, J van Sluis, R H J A Slart, A W J M Glaudemans, F F A IJpma
[18F]NaF PET/CT to assess bone healing capacity in orthopaedic trauma surgery: a feasibility study
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-025-07209-y
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OBJECTIVE: Evaluation of bone healing potential in cases of delayed union or non-union remains a challenge. This study evaluated the use of [ 18F]NaF PET/CT to assess bone healing and its role in guiding clinical decision-making in orthopaedic trauma surgery. METHODS: From June 2019 to December 2024, a prospective study was conducted in a level 1 trauma center. The study included 18 patients (20 fractures: 15 non-unions, 5 bone defects) all showing impaired bone healing after initial surgical fracture treatment, who were eligible for revision surgery. Dynamic (first...
Vancomycin-based tracers guiding in situ visualization of bacteria on osteosynthesis devices and surgical debridement
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-025-07249-4
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PURPOSE: Bacterial infections associated with musculoskeletal injuries are challenging to detect and distinguish from sterile inflammation. Here we present the combined first-time application of a bacteria-targeted positron emission tomography (PET) tracer and a near-infrared fluorescent tracer to detect infected osteosynthesis implants and guide surgical treatment. METHODS: To this end, osteosynthesis plates covered with bacterial biofilm and pre-incubated with [ 18F]PQ-VE1-vancomycin for PET imaging and/or vancomycin-IRDye800CW for optical imaging were fixed to post-mortem human tibiae and femora. PET/CT and fluorescence imaging were used to quantify the bacterial load before...
Gerbren B Spoelstra, Philip H Elsinga, Jan Maarten van Dijl, Johannes H van Snick, Ben L Feringa, Andor W J M Glaudemans, Bas Keizers, Schelto Kruijff, Wiktor Szymanski, Marleen van Oosten, Frank F A IJpma
Correction: Bosch et al. Diagnostic Value of Increased [18F]FDG Uptake in Locoregional Lymph Nodes on PET/CT in Patients with Suspected Fracture-Related Infection. Diagnostics 2025, 15, 616.
Published in: Diagnostics
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10.3390/diagnostics15151894
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Paul Bosch, Andor W J M Glaudemans, Jean-Paul P M de Vries, Johannes H van Snick, Justin V C Lemans, Janna van den Kieboom, Monique G G Hobbelink, Geertje A M Govaert, Frank F A IJpma