Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Using machine learning to improve the diagnostic accuracy of the modified Duke/ESC 2015 criteria in patients with suspected prosthetic valve endocarditis: a proof of concept study
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-024-06774-y
document
Introduction: Prosthetic valve endocarditis (PVE) is a serious complication of prosthetic valve implantation, with an estimated yearly incidence of at least 0.4-1.0%. The Duke criteria and subsequent modifications have been developed as a diagnostic framework for infective endocarditis (IE) in clinical studies. However, their sensitivity and specificity are limited, especially for PVE. Furthermore, their most recent versions (ESC2015 and ESC2023) include advanced imaging modalities, e.g., cardiac CTA and [18F]FDG PET/CT as major criteria. However, despite these significant changes, the weighing system using major and minor criteria has remained...
D. ten Hove, R. H.J.A. Slart, A. W.J.M. Glaudemans, D. F. Postma, A. Gomes, L. E. Swart, W. Tanis, P. P. van Geel, G. Mecozzi, R. P.J. Budde, K. Mouridsen, B. Sinha
Current and Emerging Radiotracers in Molecular Cardiovascular Imaging
Published in: Circulation-Cardiovascular Imaging
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10.1161/CIRCIMAGING.123.016323
document
Cardiovascular imaging has rapidly advanced over the past decades. Traditional imaging techniques such as echocardiography, computed tomography, and cardiovascular magnetic resonance are essential for assessing the structural and functional aspects of the cardiovascular system but often fall short in providing direct insights into disease activity. This gap is increasingly being bridged by molecular nuclear imaging techniques, including positron emission tomography and single-photon emission computed tomography, which enable the visualization of disease processes at the molecular and cellular levels. This review highlights the role of cardiovascular molecular imaging, emphasizing...
Shruti S Joshi, Jolien Geers, Alessia Gimelli, Fabien Hyafil, Gilbert Habib, Paola Erba, Olivier Gheysens, Andor W J M Glaudemans, David E Newby, Riemer H J A Slart, Marc R Dweck
EANM/SNMMI guideline/procedure standard for [ 18F]FDG hybrid PET use in infection and inflammation in adults v2.0.
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-024-06915-3
document
INTRODUCTION: Hybrid [ 18F]FDG PET imaging is currently the method of choice for a wide variety of infectious and inflammatory disorders and was recently adopted in several clinical guidelines. A large amount of evidence-based articles, guidelines and appropriate use criteria have been published since the first version of this guideline in 2013. PURPOSE: To provide updated evidence-based information to assist physicians in recommending, performing and interpreting hybrid [ 18F]FDG PET examinations for infectious and inflammatory disorders in the adult population. METHODS: A systematic literature search of evidence-based articles...
Gad Abikhzer, Giorgio Treglia, Matthieu Pelletier-Galarneau, John Buscombe, Arturo Chiti, Elizabeth H Dibble, Andor W J M Glaudemans, Christopher J Palestro, Mike Sathekge, Alberto Signore, Francois Jamar, Ora Israel, Olivier Gheysens
[18F]FDG PET/CT imaging of spinal infections
Published in: Clinical and Translational Imaging
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10.1007/s40336-024-00629-0
document
The annual incidence of spinal infections has been rising significantly over the last years and is expected to increase even further. Spinal infections may include infection of the vertebral body and intervertebral disc (spondylodiscitis), paravertebral abscess, epidural abscess and septic arthritis of the facet joints. Positron emission tomography (PET) with [18F]FDG has high sensitivity for detecting spinal infections, may help in differentiating between spinal infection subtypes and is able to detect dissemination of infection outside the spine. [18F]FDG PET/CT is especially indicated if MRI is inconclusive, in patients...
Erik T. te Beek, Marc R.J. ten Broek, Sakar Abdul-Fatah, Andor W.J.M. Glaudemans
Clinical Performance Comparison of a Long Versus a Short Axial Field-of-View PET/CT Using EARL-Compliant Reconstructions
Published in: Molecular Imaging and Biology
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10.1007/s11307-024-01939-5
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PURPOSE: To ensure comparable PET/CT image quality between or within centres, clinical inter-system performance comparisons following European Association of Nuclear Medicine Research Ltd. (EARL) guidelines is required. In this work the performance of the long axial field-of-view Biograph Vision Quadra is compared to its predecessor, the short axial field-of-view Biograph Vision. PROCEDURES: To this aim, patients with suspected tumour lesions received a single weight-based (3 MBq/kg) 2-deoxy-2-[ 18F]fluoro-D-glucose injection and underwent routine clinical ( ∼ 15 min) scans on the Vision and 3-min scans on the Quadra in...