Lydia Visser
PhD
My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.
A Meta-Analysis Of Hodgkin Lymphoma Reveals 19p13.3 (TCF3) As a Novel Susceptibility Loc
Wendy Cozen, Dalin Li, Maria Timofeeva, Arjan Diepstra, Dennis Hazelett, Manon Delahaye-Sourdeix, Christopher K. Edlund, Klaus Rostgaard, David J. Van Den Berg, Lude Franke, Karin Eckstrom Smedby, Sally L. Glaser, Harm-Jam Westra, Leslie L. Robison, Thomas M. Mack, Herve Ghesquieres, Arnie E. Hwang, Alexandra Nieters, Silvia de Sanjose, Victoria K. CortessisTracy Lightfoot, Nikolaus Becker, Marc Maynadie, Lenka Foretova, Eve Roman, Yolanda Benavente, Bharat N. Nathwani, Bengt Glimelius, Anthony Staines, Paolo Boffetta, Brian K. Link, L. A. Kiemeney, Stephen M. Ansell, Smita Bhatia, Louise C. Strong, Pilar Galan, Lars Vatten, Thomas M. Habermann, Eric J. Duell, Annette Lake, Rianne Veenstra, Lydia Visser, Kevin Urayama, Dorothy Montgomery, Valerie Gaborieau, Lawrence Weiss, Graham Byrnes, Mark Lathrop, Hans-Olov Adami, Mads Melbye, James R. Cerhan, Alice Gallagher, G. Malcolm Taylor, Susan L. Slager, Paul Brennan, David V. Conti, Gerhard Coetzee, Kenan Onel, Ruth F. Jarrett, Henrik Hjalgrim, Anke Van Den Berg, James D. McKay
The Role of MicroRNAs in Hodgkin’s Lymphoma
Published in: MicroRNAs in Medicine
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10.1002/9781118300312.ch26
In this chapter, we summarize the current knowledge on microRNA (miRNA) expression, function and putative clinical value in Hodgkin’s lymphoma (HL). HL is the second most common lymphoma subtype, and mainly affects young adults or elderly. Malignant cells in HL are scarce, usually less than 1%, and these cells are of B-cell origin. As miRNAs are involved in almost all known biological processes, deregulation of miRNAs is thought to play an important role in the pathogenesis of HL. MiRNA expression studies have been performed on HL cell lines,...
PML nuclear bodies and SATB1 are associated with HLA class I expression in EBV+ Hodgkin lymphoma
Published in: PLoS ONE
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10.1371/journal.pone.0072930
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Tumor cells of classical Hodgkin lymphoma (cHL) are characterized by a general loss of B cell phenotype, whereas antigen presenting properties are commonly retained. HLA class I is expressed in most EBV+ cHL cases, with an even enhanced expression in a proportion of the cases. Promyelocytic leukemia protein (PML) and special AT-rich region binding protein 1 (SATB1) are two global chromatin organizing proteins that have been shown to regulate HLA class I expression in Jurkat cells. We analyzed HLA class I, number of PML nuclear bodies (NBs) and...
Yuxuan Liu, Anke van den Berg, Rianne Veenstra, Bea Rutgers, Ilja Nolte, Gustaaf van Imhoff, Lydia Visser, Arjan Diepstra
HLA Associations in Classical Hodgkin Lymphoma: EBV Status Matters
Published in: PLoS ONE
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10.1371/journal.pone.0039986
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The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients using a PCR-based sequence-specific oligonucleotide probe (SSOP) hybridization approach. The allele frequencies were compared to HLA typings of more than 6,000 controls. The age of the cHL patients varied between 13 and 81 years with a median of 35 years. Nodular sclerosis subtype was the most common subtype (87%) and EBV was detected in...
Xin Huang, Kushi Kushekhar, Ilja Nolte, Wierd Kooistra, Lydia Visser, Ilby Bouwman, Niels Kouprie, Rianne Veenstra, Gustaaf van Imhoff, Bianca Olver, Richard S. Houlston, Sibrand Poppema, Arjan Diepstra, Bouke Hepkema, Anke van den Berg
ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis
Published in: Nephrology Dialysis Transplantation
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10.1093/ndt/gfr583
Background. Interstitial fibrosis and tubular atrophy (IF/TA) is an important cause of renal function loss and ischaemia-reperfusion (I/R) injury is considered to play an important role in its pathophysiology. The aim of the present study was to investigate the role of a disintegrin and metalloproteinase 17 (ADAM17) in human renal allograft disease and in experimental I/R injury of the kidney. Methods. We studied the expression of ADAM17 messenger RNA (mRNA) in IF/TA and control kidneys by reverse transcription-polymerase chain reaction and in situ hybridization. Moreover, we assessed ADAM17-mediated...
Gemma M. Mulder, Wynand B. W. H. Melenhorst, Johanna W. A. M. Celie, Niels J. Kloosterhuis, Jan-Luuk Hillebrands, Rutger J. Ploeg, Marc A. Seelen, Lydia Visser, Marcory C. R. F. van Dijk, Harry van Goor