Lydia Visser
PhD
My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.
Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups (Retracted article. See vol. 118, pg. 5211, 2011)
Published in: Blood
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10.1182/blood-2011-04-342998
The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients and more than 5000 controls using a PCR-based sequence-specific oligonucleotide probe hybridization approach. HLA-A68 and HLA-DR11 (5) were significantly increased in the cHL patient population compared with the controls. Three class II associations were observed in the EBV- cHL population with an increase of HLA-DR15 (2) and a decrease of HLA-DR4 and HLA-DR7. Allele...
Xin Huang, Kushi Kushekhar, Ilja Nolte, Wierd Kooistra, Lydia Visser, Ilby Bouwman, Niels Kouprie, Gustaaf van Imhoff, Bianca Olver, Richard S. Houlston, Sibrand Poppema, Arjan Diepstra, Bouke Hepkema, Anke van den Berg, R. Veenstra
EXPRESSION OF THE C-MET ONCOGENE CORRELATES WITH FAVORABLE PROGRESSION FREE SURVIVAL IN CLASSICAL HODGKIN LYMPHOMA
C. Xu, A. van den Berg, W. Plattel, N. Ruether, X. Huang, M. Wang, D. de Jong, H. Vos, G. van Imhoff, A. Viardot, P. Moeller, S. Poppema, A. Diepstra, L. Visser
Expression of CD1d and presence of invariant NKT cells in classical Hodgkin lymphoma
Published in: American Journal of Hematology
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10.1002/ajh.21743
Chuanhui Xu, Riemer de Vries, Lydia Visser, Arjan Diepstra, Stephan D. Gadola, Sibrand Poppema, Anke van den Berg
Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury
Published in: The Journal of Pathology
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10.1002/path.2698
The epidermal growth factor (EGF) receptor and its ligands are crucially involved in the renal response to ischaemia. We studied the heparin binding-epidermal growth factor (HB-EGF), a major ligand for the EGF receptor, in experimental and human ischaemia/reperfusion injury (IRI). HB-EGF mRNA and protein expression was studied in rat kidneys and cultured human tubular (HK-2) cells that were subjected to IRI and in human donor kidneys during transplantation. The effect of EGF receptor inhibition was investigated in vivo and in vitro. Furthermore, urinary HB-EGF protein excretion was studied...
Gemma M. Mulder, Willemijn N. Nijboer, Marc A. Seelen, Maria Sandovici, Eelke M. Bos, Wynand B. W. H. Melenhorst, Monika Trzpis, Niels J. Kloosterhuis, Lydia Visser, Rob H. Henning, Henri G. D. Leuvenink, Rutger J. Ploeg, Susan W. Sunnarborg, Harry van Goori
Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients
Published in: PLoS ONE
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10.1371/journal.pone.0010865
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Background: In Caucasian populations, the tumor cells of Epstein Barr virus (EBV)-positive classical Hodgkin Lymphomas (cHL) patients more frequently express HLA class I and HLA class II molecules compared to EBV-negative cHL patients. HLA expression (in relation to EBV) in Asian cHL patients has not been previously investigated. Methodology/Principal Findings: We randomly selected 145 cHL patients with formalin-fixed, paraffin embedded tissue blocks available from 5 hospitals from the Northern part of China. Hematoxylin & Eosin-stained slides were used to reclassify the histological subtypes according to the WHO classification....
Xin Huang, Anke van den Berg, Zifen Gao, Lydia Visser, Ilja Nolte, Hans Vos, Bouke Hepkema, Wierd Kooistra, Sibrand Poppema, Arjan Diepstra