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Joost Kluiver
dr.

I have a central role in all research projects focusing on the role of noncoding RNAs. My main aim is to understanding how small and long non-coding RNAs contribute to the pathogenesis of B-cell lymphoma. Ongoing studies include MYC-regulated miRNAs and lncRNAs, as well as miRNA-lncRNA interactions and the role of circular RNAs. We apply state-of-the-art methodology including AGO2-RIP, RNA-FISH and gain- and loss-of-function screens using shRNA and CRISPR-Cas technology.

Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma
Published in: Oncotarget
Access to document 10.18632/oncotarget.6165 document
Several studies have indicated an important role for miR-155 in the pathogenesis of B-cell lymphoma. Highly elevated levels of miR-155 were indeed observed in most B-cell lymphomas with the exception of Burkitt lymphoma (BL). However, the molecular mechanisms that underlie the oncogenic role of miR-155 in B-cell lymphoma are not well understood. To identify the miR-155 targets relevant for B-cell lymphoma, we performed RNA immunoprecipitation of Argonaute 2 in Hodgkin lymphoma (HL) cells upon miR-155 inhibition and in BL cells upon ectopic expression of miR-155. We identified 54...
Joost Kluiver, Izabella Slezak-Prochazka, Debora de Jong, Katarzyna Smigielska, Gertrud Kortman, Melanie Winkle, Bea Rutgers, Jasper Koerts, Lydia Visser, Arjan Diepstra, Bart-Jan Kroesen, Anke van den Berg
Transforming Growth Factor Beta Affects Mirna Expression In Control And COPD Fibroblasts
J. Ong, W. Timens, V. Rajendran, A. Algra, A. Spira, M. Lenburg, J. Campbell, D. S. Postma, A. Van den Berg, J. Kluiver, Corry-Anke Brandsma
Mir-155 Enhances B-Cell Lymphoma Growth By Targeting TBRG1
Joost Kluiver, Izabella Slezak, Melanie Winkle, Lydia Visser, Arjan Diepstra, Bart-Jan Kroesen, Anke Van den Berg
KNOWN AND NOVEL MICRORNA EXPRESSION PROFILES IN BRCA1-ASSOCIATED PELVIC HIGH-GRADE SEROUS CANCER
J. Brouwer, R. C. de Almeida, J. Kluiver, W. Reitsma, R. Modderman, S. Withoff, H. Hollema, G. H. de Bock, M. J. E. Mourits, Anke Berg, van den
Age-Associated Differences in MiRNA Signatures Are Restricted to CD45RO Negative T Cells and Are Associated with Changes in the Cellular Composition, Activation and Cellular Ageing
Published in: PLoS ONE
Access to document 10.1371/journal.pone.0137556 document
MicroRNAs (miRNAs) have emerged as important players in the regulation of T-cell functionality. However, comprehensive insight into the extent of age-related miRNA changes in T cells is lacking. We established miRNA expression patterns of CD45RO- naive and CD45RO+ memory T-cell subsets isolated from peripheral blood cells from young and elderly individuals. Unsupervised clustering of the miRNA expression data revealed an age-related clustering in the CD45RO- T cells, while CD45RO+ T cells clustered based on expression of CD4 and CD8. Seventeen miRNAs showed an at least 2-fold up-or downregulation...
Nato Teteloshvili, Joost Kluiver, Kornelis S. M. van der Geest, Roelof Jan van der Lei, Pytrick Jellema, Graham Pawelec, Elisabeth Brouwer, Bart-Jan Kroesen, Annemieke M. H. Boots, Anke van den Berg