Anke van den Berg
prof. dr.
I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.
Genomic aberrations guiding treatment of non-small cell lung cancer patients
Published in: Cancer Treatment Communications
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10.1016/j.ctrc.2015.03.005
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CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma
Published in: Experimental Hematology & Oncology
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10.1186/s40164-015-0022-1
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BACKGROUND: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is characterized by lymphocyte-predominant (LP) cells in a background of CD4+ CD57+ T-cells. These cells are normally present in the germinal center of lymphoid tissues. The cells rosetting LP cells are described to be PD-1 and BCL-6 positive, which are markers of T-follicular helper cells. This study was designed to address the question: are the CD57+ T cells in germinal centers of tonsil and NLPHL TFH cells? RESULTS: Immunohistochemistry was performed on tonsil and NLPHL. For tonsil, cells per germinal center...
T-Cell Activation induces Dynamic Changes in miRNA Expression Patterns in CD4 and CD8 T-Cell Subsets
Published in: MicroRNA
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10.2174/2211536604666150819194636
T-cell activation affects microRNA (miRNA) expression in T-cell subsets. However, little is known about the kinetics of miRNA regulation and possible differences between CD4 and CD8 T cells. In this study we set out to analyze the kinetics of activation-induced expression regulation of twelve pre-selected miRNAs. The dynamics of the expression of these miRNAs was studied in sorted CD4 and CD8 CD45RO- T cells of healthy individuals stimulated with αCD3/αCD28 antibodies. Analysis of miRNA levels at day 3, 5, 7 and 10 showed significant activation-induced changes in expression...
Nato Teteloshvili, Katarzyna Smigielska-Czepiel, Bart-Jan Kroesen, Elisabeth Brouwer, Joost Kluiver, Anke van den Berg, Anna Boots
Immuno-miRs: critical regulators of T-cell development, function and ageing
Published in: Immunology
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10.1111/imm.12367
MicroRNAs (miRNAs) are instrumental to many aspects of immunity, including various levels of T-cell immunity. Over the last decade, crucial immune functions were shown to be regulated by specific miRNAs. These immuno-miRs’ regulate generic cell biological processes in T cells, such as proliferation and apoptosis, as well as a number of T-cell-specific features that are fundamental to the development, differentiation and function of T cells. In this review, we give an overview of the current literature with respect to the role of miRNAs at various stages of T-cell...
Bart-Jan Kroesen, Nato Teteloshvili, Katarzyna Smigielska, Elisabeth Brouwer, Annemieke Boots, Anke van den Berg, Joost Kluiver
Meta-Analysis of Hodgkin Lymphoma and Asthma Genome-Wide Association Scans reveals common variants in GATA3
Yinfei Kong, Pouya Khankhanian, Daniel Himmelstein, Amie E. Hwang, Kristin A. Rand, Dalin Li, David J. Van Den Berg, Arjan Diepstra, David V. Conti, Smita Bhatia, Pierre-Antoine Gourraud, Sally L. Glaser, Thomas M. Mack, Jorge Oksenberg, Kenan Onel, Anke Van Den Berg, Ruth F. Jarrett, James D. Mckay, Henrik Hjalgrim, Sergio BaranziniFrank D. Gilliland, W. James Gauderman, Wendy Cozen