Anke van den Berg
prof. dr.
I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.
Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas
Since Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) generally have immunoglobulin gene rearrangements, they are considered to be of B-cell origin. One of the characteristics of HRS cells is a prominent production of various cytokines and chemokines. Cytokine production is generally driven by expression of T-cell transcription factors (TFs). Only limited information is available on the expression of T-cell TFs in HL. Expression of four T-cell TFs and the target cytokine spectrum of these TFs were analyzed in six HL and three large B-cell lymphoma (LBCL)...
C Atayar, S Poppema, T Blokzijl, G Harms, M Boot, Anke van den Berg
Dimeric galectin-1 induces IL-10 production in T-lymphocytes: an important tool in the regulation of the immune response
Published in: The Journal of Pathology
Access to document
10.1002/path.1671
J. Van der Leij, Anke van den Berg, T. Blokzijl, G. Harms, H. van Goor, Peter Zwiers, Robert van Weeghel, Sibrand Poppema, Lydia Visser
Enhanced ecto-apyrase activity of stimulated endothelial or mesangial cells is downregulated by glucocorticolds in vitro
Published in: European Journal of Pharmacology
Access to document
10.1016/j.ejphar.2004.08.008
Jola Jovita Kapojos, Anke van den Berg, Theo Borghuis, B. Banas, Sipkje Huitema, Klaas Poelstra, W.W Bakker
Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations
Published in: Leukemia and Lymphoma
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10.1080/10428190310001593166
Autoimmune Lymphoproliferative Syndrome (ALPS) is generally the result of a mutation in genes associated with apoptosis, like Fas, Fas ligand, Casp 8 and Casp 10. As a result, the normal homeostasis of T- and B-lymphocytes is disturbed and a proliferation of polyclonal T lymphocytes occurs. This leads to hepatosplenomegaly and lymphadenopathy and in most patients also to autoimmune phenomena like anemia and thrombocytopenia. The proliferating T cells are TCRalphabeta and/or TCRgammadelta positive but lack both CD4 and CD8. Hence they are termed double negative (DN) T cells. In...
Sibrand Poppema, Ewerton Maggio, Anke van den Berg
Prolonged survival of rat islet xenografts in mice after CD45RB monotherapy
Published in: Transplantation
Access to document
10.1097/01.TP.0000111741.85249.EC
Lydia Visser, Sibrand Poppema, Bart de Haan, Pieter Klok, J. Van der Leij, Anke van den Berg, P. de Vos