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Anke van den Berg
prof. dr.

I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.

Mir-155 Enhances B-Cell Lymphoma Growth By Targeting TBRG1
Joost Kluiver, Izabella Slezak, Melanie Winkle, Lydia Visser, Arjan Diepstra, Bart-Jan Kroesen, Anke Van den Berg
Microenvironment, crosstalk, and immune escape mechanisms
Published in: Hematologic Malignancies
Access to document 10.1007/978-3-319-12505-3_4
Lydia Visser, Anke Van Den Berg, Sibrand Poppema, Arjan Diepstra
A Novel Risk Locus at 6p21.3 for Epstein-Barr Virus-Positive Hodgkin Lymphoma
Published in: Cancer Epidemiology, Biomarkers & Prevention
Access to document 10.1158/1055-9965.EPI-15-0534
Background: A proportion of the genetic variants involved in susceptibility to Hodgkin lymphoma differ by the tumor’s Epstein-Barr virus (EBV) status, particularly within the MHC region. Methods: We have conducted an SNP imputation study of the MHC region, considering tumor EBV status in 1,200 classical Hodgkin lymphoma (cHL) cases and 5,726 control subjects of European origin. Notable findings were genotyped in an independent study population of 468 cHL cases and 551 controls. Results: We identified and subsequently replicated a novel association between a common genetic variant rs6457715 and...
Manon Delahaye-Sourdeix, Kevin Y. Urayama, Valerie Gaborieau, Rianne Veenstra, Matthieu Foll, Amelie Chabrier, Yolanda Benavente, Alexandra Nieters, Nikolaus Becker, Lenka Foretova, Marc Maynadie, Anthony Staines, Karin Ekstrom Smedby, Ingrid Glimelius, Tracy Lightfoot, Pierluigi Cocco, Pilar Galan, Lars J. Vatten, Eric J. Duell, Lambertus KiemeneyEve Roman, Silvia de Sanjose, Mark Lathrop, Mads Melbye, Paul Brennan, Arjan Diepstra, Anke Van den Berg, Henrik Hjalgrim, Ruth F. Jarrett, James D. McKay
KNOWN AND NOVEL MICRORNA EXPRESSION PROFILES IN BRCA1-ASSOCIATED PELVIC HIGH-GRADE SEROUS CANCER
J. Brouwer, R. C. de Almeida, J. Kluiver, W. Reitsma, R. Modderman, S. Withoff, H. Hollema, G. H. de Bock, M. J. E. Mourits, Anke Berg, van den
Age-Associated Differences in MiRNA Signatures Are Restricted to CD45RO Negative T Cells and Are Associated with Changes in the Cellular Composition, Activation and Cellular Ageing
Published in: PLoS ONE
Access to document 10.1371/journal.pone.0137556 document
MicroRNAs (miRNAs) have emerged as important players in the regulation of T-cell functionality. However, comprehensive insight into the extent of age-related miRNA changes in T cells is lacking. We established miRNA expression patterns of CD45RO- naive and CD45RO+ memory T-cell subsets isolated from peripheral blood cells from young and elderly individuals. Unsupervised clustering of the miRNA expression data revealed an age-related clustering in the CD45RO- T cells, while CD45RO+ T cells clustered based on expression of CD4 and CD8. Seventeen miRNAs showed an at least 2-fold up-or downregulation...
Nato Teteloshvili, Joost Kluiver, Kornelis S. M. van der Geest, Roelof Jan van der Lei, Pytrick Jellema, Graham Pawelec, Elisabeth Brouwer, Bart-Jan Kroesen, Annemieke M. H. Boots, Anke van den Berg