I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists.
Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
A phase 1 study of RAD1901, an oral selective estrogen receptor degrader, to determine changes in the F-18-FES uptake and tumor responses in ER-positive, HER2-negative, advanced breast cancer patients
Published in: Cancer Research
Nuclear medicine imaging of multiple myeloma, particularly in the relapsed setting
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Multiple myeloma (MM) is characterized by a monoclonal plasma cell population in the bone marrow. Lytic lesions occur in up to 90 % of patients. For many years, whole-body X-ray (WBX) was the method of choice for detecting skeleton abnormalities. However, the value of WBX in relapsing disease is limited because lesions persist post-treatment, which restricts the capacity to distinguish between old, inactive skeletal lesions and new, active ones. Therefore, alternative techniques are necessary to visualize disease activity. Modern imaging techniques such as magnetic resonance imaging, positron emission...
Diagnostic value of imaging in infective endocarditis: a systematic review
Published in: Lancet Infectious Diseases
Sensitivity and specificity of the modified Duke criteria for native valve endocarditis are both suboptimal, at approximately 80%. Diagnostic accuracy for intracardiac prosthetic material-related infection is even lower. Non-invasive imaging modalities could potentially improve diagnosis of infective endocarditis; however, their diagnostic value is unclear. We did a systematic literature review to critically appraise the evidence for the diagnostic performance of these imaging modalities, according to PRISMA and GRADE criteria. We searched PubMed, Embase, and Cochrane databases. 31 studies were included that presented original data on the performance of...
Anna Gomes,
Andor W J M Glaudemans,
Daan J Touw,
Joost P van Melle,
Tineke P Willems,
Alexander H Maass, Ehsan Natour,
Niek H J Prakken,
Ronald J H Borra, Peter Paul van Geel,
Riemer H J A Slart, Sander van Assen,
Bhanu Sinha
Quality in Nuclear Medicine
Linagliptin Reduces Arterial Stiffness and Arterial Inflammation in Persons With Early Type 2 Diabetes: a Double-blind, Randomized Controlled Trial
