Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Arterial Stiffness Is Positively Associated With F-18-fluorodeoxyglucose Positron Emission Tomography-Assessed Subclinical Vascular Inflammation in People With Early Type 2 Diabetes
Published in: Diabetes Care
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10.2337/dc16-0327
OBJECTIVEType 2 diabetes is accompanied by premature atherosclerosis and arterial stiffness. The underlying association remains incompletely understood. The possible relationship between subclinical arterial inflammation assessed by F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and arterial stiffness was investigated in patients with early type 2 diabetes.RESEARCH DESIGN AND METHODSPatients with type 2 diabetes (n = 44), without cardiovascular disease and any type of antidiabetic medication, were studied (median age 63 years [interquartile range 54-66], men:women 27:17). Arterial inflammation was quantified as the FDG uptake maximal standardized uptake value (SUVmax)....
Stefanie A. de Boer, Marieke C. Hovinga-de Boer, Hiddo J. L. Heerspink, Joop D. Lefrandt, Arie M. van Roon, Helen L. Lutgers, Andor W. J. M. Glaudemans, Pieter W. Kamphuisen, Riemer H. J. A. Slart, Douwe J. Mulder
Nuclear medicine imaging of posttraumatic osteomyelitis
Published in: European Journal of Trauma and Emergency Surgery
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10.1007/s00068-016-0647-8
document
Early recognition of a possible infection and therefore a prompt and accurate diagnostic strategy is essential for a successful treatment of posttraumatic osteomyelitis (PTO). However, at this moment there is no single routine test available that can detect osteomyelitis beyond doubt and the performed diagnostic tests mostly depend on personal experience, available techniques and financial aspects. Nuclear medicine techniques focus on imaging pathophysiological changes which usually precede anatomical changes. Together with recent development in hybrid camera systems, leading to better spatial resolution and quantification possibilities, this provides new...
G. A. M. Govaert, A. W. J. M. Glaudemans
Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis
Published in: Circulation
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10.1161/CIRCULATIONAHA.116.021612
Background-Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal cardiomyopathy for which several promising therapies are in development. The diagnosis is frequently delayed or missed because of the limited specificity of echocardiography and the traditional requirement for histological confirmation. It has long been recognized that technetium-labeled bone scintigraphy tracers can localize to myocardial amyloid deposits, and use of this imaging modality for the diagnosis of cardiac ATTR amyloidosis has lately been revisited. We conducted a multicenter study to ascertain the diagnostic value of bone scintigraphy in this disease....
Julian D. Gillmore, Mathew S. Maurer, Rodney H. Falk, Giampaolo Merlini, Thibaud Damy, Angela Dispenzieri, Ashutosh D. Wechalekar, John L. Berk, Candida C. Quarta, Martha Grogan, Helen J. Lachmann, Sabahat Bokhari, Adam Castano, Sharmila Dorbala, Geoff B. Johnson, Andor W. J. M. Glaudemans, Tamer Rezk, Marianna Fontana, Giovanni Palladini, Paolo MilaniPierluigi L. Guidalotti, Katarina Flatman, Thirusha Lane, Frederick W. Vonberg, Carol J. Whelan, James C. Moon, Frederick L. Ruberg, Edward J. Miller, David F. Hutt, Bouke P. Hazenberg, Claudio Rapezzi, Philip N. Hawkins
Somatostatin receptor scintigraphy in patients with rheumatoid arthritis and secondary Sjogren’s syndrome treated with Infliximab: a pilot study
Published in: EJNMMI Research
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10.1186/s13550-016-0202-y
document
Background: Human T lymphocytes infiltrating tissues in autoimmune diseases are known to express somatostatin receptors amongst other activation markers. In this study, we evaluated whether somatostatin receptor scintigraphy (SRS) using a radiolabelled somatostatin analogue (Tc-99m-EDDA/tricine-HYNIC-tyr(3)-octreotide (Tc-99m-EDDA/HYNIC-TOC)) is able to detect the presence of immune-mediated processes in patients with rheumatoid arthritis and secondary Sjogren’s syndrome. We also aimed to evaluate whether positivity to SRS was predictive of therapeutic response and if SRS could be used for monitoring the efficacy of immunomodulatory treatment. Methods: Eighteen patients with rheumatoid arthritis and...
L. K. Anzola-Fuentes, M. Chianelli, F. Galli, A. W. J. M. Glaudemans, L. Martin Martin, V. Todino, A. Migliore, A. Signore
In vivo imaging of microorganisms
Published in: Clinical and Translational Imaging
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10.1007/s40336-016-0176-9
Alberto Signore, Iolanda Santino, Andor W.J.M. Glaudemans