Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
F-18-FES PET Has Added Value in Staging and Therapy Decision Making in Patients With Disseminated Lobular Breast Cancer
Published in: Clinical Nuclear Medicine
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10.1097/RLU.0000000000001724
Lobular breast cancer is the second most common type of invasive breast cancer. Lobular breast cancer lesions are often difficult to detect with conventional imaging because they tend to grow less cohesively than ductal cancer. These images represent 3 lobular breast cancer cases, in whom confirmation of metastatic disease would make the crucial difference between curative or noncurative treatment. Staging with conventional imaging, however, yielded equivocal results, and a biopsy was not feasible. In contrast, FES (16 alpha-[F-18]fluoro-17 beta-estradiol) PET provided a decisive contribution to clinical decision making...
FDG-PET/CT as a New Method for Diagnosis and Whole-Body Evaluation of Lemierre Syndrome
Published in: Clinical Nuclear Medicine
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10.1097/RLU.0000000000001708
Lemierre syndrome is a rare disease that is defined by a pharyngeal infection, complicated by septicemia and internal jugular vein thrombosis followed by septic emboli. Because of its rarity, a delay in diagnosis is not uncommon. However, given the mortality rate of approximately 2%, prompt diagnosis and detection of septic emboli are essential to initiate prompt treatment, preventing organ damage and ongoing sepsis. We present 3 cases that demonstrate the value of FDG-PET/CT as a possible alternative or adjunct to conventional imaging methods for diagnosis and whole-body evaluation...
Late onset cardiomyopathy as presenting sign of ATTR A45G amyloidosis caused by a novel TTR mutation (p.A65G)
Published in: Cardiovascular Pathology
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10.1016/j.carpath.2017.04.002
document
Objective: The clinical description of a novel TTR genemutation characterized by a late onset amyloid cardiomyopathy. Methods and Results: A 78-year-old man of Dutch origin with recent surgeryforbilateral carpal tunnel syndrome(CTS) was admitted to our hospital because of heart failure with preserved ejection fraction (55%). Cardiac ultrasound showed thickened biventricular walls, and cardiac magnetic resonance imaging also showed late gadolinium enhancement. Early signs of a polyneuropathy were found by neurophysiological testing. A few months later, his 72year- old sister was admitted to an affiliated hospital because of heart...
Sebastiaan H. C. Klaassen, Henny H. Lemmink, Johan Bijzet, Andor W. J. M. Glaudemans, Reinhard Bos, Wouter Plattel, Maarten P. van den Berg, Riemer H. J. A. Slart, Hans L. A. Nienhuis, Dirk J. van Veldhuisen, Bouke P. C. Hazenberg
Accuracy of diagnostic imaging modalities for peripheral post-traumatic osteomyelitis: a systematic review of the recent literature
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-017-3683-7
document
Post-traumatic osteomyelitis (PTO) is difficult to diagnose and there is no consensus on the best imaging strategy. The aim of this study is to present a systematic review of the recent literature on diagnostic imaging of PTO. A literature search of the EMBASE and PubMed databases of the last 16 years (2000-2016) was performed. Studies that evaluated the accuracy of magnetic resonance imaging (MRI), three-phase bone scintigraphy (TPBS), white blood cell (WBC) or antigranulocyte antibody (AGA) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and plain computed tomography (CT) in...
Geertje A Govaert, Frank F IJpma, Martin McNally, Eugene McNally, Inge H Reininga, Andor W Glaudemans
In vitro imaging of bacteria using (18)F-fluorodeoxyglucose micro positron emission tomography
Published in: Scientific Reports
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10.1038/s41598-017-05403-z
document
Positron emission tomography (PET) with fluorine-18-fluorodeoxyglucose ((18)F-FDG) can be applied to detect infection and inflammation. However, it was so far not known to what extent bacterial pathogens may contribute to the PET signal. Therefore, we investigated whether clinical isolates of frequently encountered bacterial pathogens take up (18)F-FDG in vitro, and whether FDG inhibits bacterial growth as previously shown for 2-deoxy-glucose. 22 isolates of Gram-positive and Gram-negative bacterial pathogens implicated in fever and inflammation were incubated with (18)F-FDG and uptake of (18)F-FDG was assessed by gamma-counting and µPET imaging....