Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
Leukocyte Imaging of the Diabetic Foot
Published in: Current Pharmaceutical Design
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10.2174/1381612824666180227094116
document
Background: Diagnosing diabetic foot infection is often difficult, despite several available diagnostic methods. Amongst these, several imaging modalities exist to evaluate the diabetic foot in case of a suspected osteomyelitis. Nuclear Medicine, in particular, offers a variety of radiopharmaceuticals and techniques. Nowadays the gold standard radionuclide procedure, when an osteomyelitis is suspected, is represented by the use of radiolabelled leukocytes with either Tc-99m-HMPAO or In-111-oxine. Methods: In this review, we describe the correct acquisition and interpretation of white blood cell scintigraphy and we provide an overview of the...
Chiara Lauri, Andor W. J. M. Glaudemans, Alberto Signore
The Role of PET in Monitoring Therapy in Fungal Infections
Published in: Current Pharmaceutical Design
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10.2174/1381612824666171213101648
Positron emission tomography (PET) is a powerful diagnostic nuclear medicine imaging technique. PET allows in vivo detection of a wide variety of physiologic and pathologic phenomena and it offers a noninvasive tool for the monitoring of therapy in various diseases. Invasive fungal infections (IFIs) are a global concern because of the increasing population of patients at risk of IFIs and the high morbidity and mortality. Therapy with antifungal agents is long-standing and expensive. The emerging resistant fungal strains make the management of IFIs challenging. There is an absolute...
Alfred O Ankrah, Hans C Klein, Lambert F R Span, Erik F J de Vries, Rudi A J O Dierckx, Mike M Sathekge, Andor W J M Glaudemans
Primary tumor volume measurements in Ewing sarcoma: MRI inter- and intraobserver variability and comparison with FDG-PET
Published in: ACTA ONCOLOGICA
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10.1080/0284186X.2017.1398411
document
BACKGROUND: Primary tumor volume is as an important and independent prognostic factor in Ewing sarcoma. However, the observer variability of magnetic resonance imaging (MRI)-based primary tumor volume measurements in newly diagnosed Ewing sarcoma has never been investigated. Furthermore, it is unclear how MRI-based volume measurements compare to (18)F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)-based volume measurements. This study aimed to determine the observer variability of simplified MRI-based primary tumor volume measurements in newly diagnosed treatment-naive Ewing sarcoma and to compare them to the actual primary tumor volume at MRI...
Somatostatin receptor based hybrid imaging in sarcoidosis
Published in: European Journal of Hybrid Imaging
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10.1186/s41824-017-0014-y
document
Several diagnostic imaging methodologies are available for the clinical evaluation of sarcoidosis, but all have their limitations. FDG PET/CT is frequently used, but this technique does not provide optimal results in all cases. Novel radiopharmaceuticals aimed at other disease targets may be helpful, particularly in cardiac sarcoidosis when FDG PET/CT has a low diagnostic accuracy, due to difficulties in preparing the patients who should use a specific diet combined with prolonged fasting. 68Ga-labeled somatostatin based receptor hybrid imaging is a potential alternative to FDG PET/CT. This short communication...
Riemer H J A Slart, Klaas-Pieter Koopmans, Peter Paul van Geel, Henk Kramer, Harry J M Groen, C Tji-Joong Gan, Niek H J Prakken, Andor W J M Glaudemans, George D Nossent
Investigation into cardiac sympathetic innervation during the commencement of haemodialysis in patients with chronic kidney disease
Published in: European Radiology Experimental
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10.1186/s41747-017-0027-0
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Background: Patients with chronic kidney disease (CKD) who undergo chronic haemodialysis (HD) show altered sympathetic tone, which is related to a higher cardiovascular mortality. The purpose of this study was to investigate the effect of transition from pre-HD to HD on cardiac sympathetic innervation. Methods: Eighteen patients aged 58 ± 18 years (mean ± standard deviation [SD]), 13 males and five females, with stage 5 CKD and nine healthy control subjects aged 52 ± 17 (mean ± SD), three males and six females, were included in this prospective study between May 2010 and December 2013. All...
Walter Noordzij, Akin Özyilmaz, Andor W J M Glaudemans, René A Tio, Esther R Goet, Casper F M Franssen, Riemer H J A Slart