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Andor Glaudemans
prof. dr.

I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.

I-123-Labelled metaiodobenzylguanidine for the evaluation of cardiac sympathetic denervation in early stage amyloidosis
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Access to document 10.1007/s00259-012-2187-8
PURPOSE: Cardiac amyloidosis is a rare disorder, but it may lead to potentially life-threatening restrictive cardiomyopathy. Cardiac manifestations frequently occur in primary amyloidosis (AL) and familial amyloidosis (ATTR), but are uncommon in secondary amyloidosis (AA). Echocardiography is the method of choice for assessing cardiac amyloidosis. Amyloid deposits impair the function of sympathetic nerve endings. Disturbance of myocardial sympathetic innervations may play an important role in the remodelling process. (123)I-MIBG can detect these innervation changes. METHODS: Patients with biopsy-proven amyloidosis underwent general work-up, echocardiography and (123)I-MIBG scintigraphy. Left ventricular...
Walter Noordzij, Andor W J M Glaudemans, Ronald W J van Rheenen, Bouke P C Hazenberg, René A Tio, Rudi A J O Dierckx, Riemer H J A Slart
Adrenal Hemorrhage Causing Adrenal Insufficiency in a Patient with Antiphospholipid Syndrome: Increased Adrenal F-18-FDG Uptake
Published in: Journal of Clinical Endocrinology and Metabolism
Access to document 10.1210/jc.2012-2050
Leo Boneschansker, Marcel Nijland, Andor W J M Glaudemans, Sibylle B van der Meulen, Philip M Kluin, Robin P F Dullaart
Development and testing of a new disposable sterile device for labelling white blood cells
Aim. White blood cell (WBC) labelling requires isolation of cells from patient’s blood under sterile conditions using sterile materials, buffers and disposables under good manufacturing practice (GMP) conditions. Till now, this limited the use of white blood cell scintigraphy (WBC-S) only to well equipped laboratories with trained personnel. We invented, developed and tested a disposable, sterile, closed device for blood manipulation, WBC purification and radionuclide labelling without exposing patient’s blood and the operator to contamination risks. This device prototype and a final industrialized device (Leukokit (R)) were tested...
A. Signore, A. W. J. M. Glaudemans, G. Malviya, E. Lazzeri, N. Prandini, A. L. Viglietti, E. F. J. De Vries, R. A. J. O. Dierckx
Adverse cardiovascular effects of anabolic steroids: pathophysiology imaging
Published in: European Journal of Clinical Investigation
Access to document 10.1111/j.1365-2362.2011.02642.x
Eur J Clin Invest 2012; 42 (7): 795803 Abstract Background Anabolic-androgenic steroids (AAS) are widely abused for enhancing muscle mass, strength, growth and improving athletic performance. Materials and methods In recent years, many observational and interventional studies have shown important adverse cardiovascular effects of AAS abuse. Conclusions This review discusses established and future perspectives of novel molecular imaging techniques that may serve as potential tools for early detection of AAS-associated cardiovascular disorders.
Reza Golestani, Riemer H. J. A. Slart, Robin P. F. Dullaart, Andor W. J. M. Glaudemans, Clark J. Zeebregts, Hendrikus H. Boersma, Rene A. Tio, Rudi A. J. O. Dierckx
PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Access to document 10.1007/s00259-012-2085-0
BACKGROUND: Deterioration of left ventricular (LV) function after myocardial infarction (MI) is a major cause of heart failure. Myocardial perfusion performance may play an important role in deterioration or improvement in LV function after MI. The aim of this study was to evaluate the myocardial perfusion reserve (MPR) and stress perfusion in deteriorating and non-deteriorating LV segments in patients after MI by PET and MRI, respectively. METHODS: Regional wall thickening of 352 segments in 22 patients was assessed at 4 and 24 months after MI by cardiac MRI....
Riemer H J A Slart, Julius Glauche, Reza Golestani, Clark J Zeebregts, Jan W Jansen, Rudi A J O Dierckx, Matthijs Oudkerk, Tineke P Willems, Andor W J M Glaudemans, Hendrikus H Boersma, René A Tio