Anke van den Berg
prof. dr.
I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.
Genetic Associations in Classical Hodgkin Lymphoma: A Systematic Review and Insights into Susceptibility Mechanisms
Published in: Cancer Epidemiology, Biomarkers & Prevention
Access to document
10.1158/1055-9965.EPI-14-0683
Both targeted and genome-wide studies have revealed genetic associations for susceptibility, prognosis, and treatment-induced secondary malignancies and toxicities in classical Hodgkin lymphoma (cHL). This review gives a systematic and comprehensive overview of significant associations and places them into a biologic context. The strongest susceptibility polymorphisms have been found for the human leukocyte antigen (HLA) genes. These associations are specific for cHL overall or for subgroups based on tumor cell Epstein-Barr virus (EBV) status. These findings strongly suggest that EBV-specific immune responses influence cHL susceptibility in EBV+ cHL and...
MICRORNA EXPRESSION PROFILING OF PELVIC HIGH-GRADE SEROUS CANCER IN BRCA1 CARRIERS
J. Brouwer, M. J. E. Mourits, H. Hollema, G. H. de Bock, W. Reitsma, R. C. de Almeida, R. Modderman, S. Withoff, A. van den Berg
The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing
Published in: Leukemia
Access to document
10.1038/leu.2014.201
Y. Liu, F.R. Abdul Razak, M. Terpstra, F.C. Chan, A. Saber, M. Nijland, G. van Imhoff, Lydia Visser, R. Gascoyne, C. Steidl, J. Kluiver, A. Diepstra, K. Kok, Anke van den Berg
Embryological signaling pathways in Barrett’s metaplasia development and malignant transformation; mechanisms and therapeutic opportunities
Published in: Critical Reviews in Oncology/Hematology
Access to document
10.1016/j.critrevonc.2014.05.002
Barrett’s metaplasia of the esophagus (BE) is the precursor lesion of esophageal adenocarcinoma (EAC), a deadly disease with a 5-year overall survival of less than 20%. The molecular mechanisms of BE development and its transformation to EAC are poorly understood and current surveillance and treatment strategies are of limited efficacy. Increasing evidence suggests that aberrant signaling through pathways active in the embryological development of the esophagus contributes to BE development and progression to EAC. We discuss the role that the Bone morphogenetic protein, Hedgehog, Wingless-Type MMTV Integration Site...
Toll-like receptors in the pathogenesis of human B cell malignancies
Published in: Journal of Hematology & Oncology
Access to document
10.1186/s13045-014-0057-5
document
Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may be involved in the pathogenesis of B-cell lymphomas. Accumulating studies show differential expression in this heterogeneous group of cancers. Stimulation with TLR specific ligands, or agonists of their ligands, leads to aberrant responses in the malignant B-cells. According to current data, TLRs can be implicated in malignant transformation, tumor progression and immune evasion processes. Most of the studies focused on multiple myeloma and chronic lymphocytic leukemia, but in the last decade the putative role...