Anke van den Berg
prof. dr.
I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.
Age-related gene and microRNA expression changes in the airways of healthy individuals
Published in: European Respiratory Journal
Access to document
10.1183/13993003.congress-2018.PA4230
Roy R. Woldhuis, Jennie Ong, Ilse M. Boudewijn, Anke Van den Berg, Joost L. Kluiver, Klaas Kok, Martijn M. Terpstra, Victor Guryev, Maaike De Vries, Corneel J. Vermeulen, Wim Timens, Maarten Van den Berge, Corry-Anke Brandsma
Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells
Published in: Frontiers in Immunology
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10.3389/fimmu.2018.01400
document
Loss of CD28 is a characteristic feature of T cell aging, but the underlying mechanisms of this loss are elusive. As differential expression of microRNAs (miRNAs) has been described between CD28+ and CD28- T cells, we hypothesized that altered miRNA expression contributes to the age-associated downregulation of CD28. To avoid the confounding effects of age-associated changes in the proportions of T cells at various differentiation stages in vivo, an experimental model system was used to study changes over time in the expression of miRNA associated with the loss...
Nato Teteloshvili, Gerjan Dekkema, Annemieke M. Boots, Peter Heeringa, Pytrick Jellema, Debora de Jong, Martijn Terpstra, Elisabeth Brouwer, Graham Pawelec, Klaas Kok, Anke van den Berg, Joost Kluiver, Bart-Jan Kroesen
IDENTIFICATION OF TWO PROTEIN-SIGNALING STATES DELINEATING TRANSCRIPTIONALLY HETEROGENEOUS HUMAN MEDULLOBLASTOMA
Walderik Zomerman, Sabine Plasschaert, Siobhan Conroy, Frank Scherpen, Tiny Meeuwsen-de Boer, Harm-Jan Lourens, Sergi Guerrero Llobet, Marlinde Smit, Lorian Slagter-Menkema, Annika Seitz, Corrie Gidding, Esther Hulleman, Pieter Wesseling, Lisethe Meijer, Leon van Kempen, Anke van den Berg, Daniel Warmerdam, Frank Kruyt, Floris Foijer, Marcel van VugtWilfred den Dunnen, Eelco Hoving, Victor Guryev, Eveline de Bont, Sophia Bruggeman
The Microenvironment in Epstein-Barr Virus-Associated Malignancies
Published in: Pathogens
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10.3390/pathogens7020040
document
The Epstein-Barr virus (EBV) can cause a wide variety of cancers upon infection of different cell types and induces a highly variable composition of the tumor microenvironment (TME). This TME consists of both innate and adaptive immune cells and is not merely an aspecific reaction to the tumor cells. In fact, latent EBV-infected tumor cells utilize several specific mechanisms to form and shape the TME to their own benefit. These mechanisms have been studied largely in the context of EBV+ Hodgkin lymphoma, undifferentiated nasopharyngeal carcinoma, and EBV+ gastric...
Combined PD-1 and JAK1/2 inhibition in refractory primary mediastinal B-cell lymphoma
Published in: Annals of Hematology
Access to document
10.1007/s00277-018-3233-9
document
Marcel Nijland, Tom van Meerten, Annika Seitz, Gerwin Huls, Robby Kibbelaar, Lydia Visser, Anke van den Berg, Arjan Diepstra