Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
PET Imaging of Estrogen Receptors as a Diagnostic Tool for Breast Cancer Patients Presenting with a Clinical Dilemma
Published in: Journal of Nuclear Medicine
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10.2967/jnumed.111.092734
16 alpha-F-18-fluoro-17 beta-estradiol (F-18-FES) is an estrogen receptor (ER)-specific PET tracer with various potential interesting applications. The precise contribution of this technique in current clinical practice, however, has yet to be determined. Therefore, the aim of this study was to evaluate the value of F-18-FES PET in breast cancer patients presenting with a clinical dilemma. Methods: F-18-FES PET examination could be requested by referring physicians for patients with a history of ER-positive breast cancer and the presence of a clinical dilemma despite complete standard work-up. All requests for...
Michel van Kruchten, Andor W. J. M. Glaudemans, Regina G. H. Beets-Tan, Carolien P. Schroder, Rudi A. Dierckx, Elisabeth G. E. de Vries, Geke A. P. Hospers, Erik de Vries
The role of nuclear medicine imaging in inflammatory diseases: drug targets and clinical applications.
Published in: Trends on the role of PET in drug development
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10.1142/9789814317740_0023
An unusual cause of hyperandrogenism
M. Wendker-van Wattum, R. S. M. E. Wouters, J. E. van der Wal, A. W. J. M. Glaudemans, B. H. R. Wolffenbuttel
The molecular imaging approach to image infections and inflammation by nuclear medicine techniques
Published in: ANNALS OF NUCLEAR MEDICINE
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10.1007/s12149-011-0521-z
Inflammatory and infectious diseases are a heterogeneous class of diseases that may be divided into infections, acute inflammation and chronic inflammation. Radiological imaging techniques have, with the exception of functional MRI, high sensitivity but lack in specificity. Nuclear medicine techniques, by contrast, allow the in vivo detection in humans of different physiologic and pathologic phenomena and offer noninvasive tools to detect early pathophysiological changes before anatomical changes occur. In this review, we highlight the role of nuclear medicine in inflammation/infection with emphasis on molecular imaging for in vivo...
High-resolution imaging of human atherosclerotic carotid plaques with micro(18)F-FDG PET scanning exploring plaque vulnerability
Published in: Journal of Nuclear Cardiology
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10.1007/s12350-011-9460-2
FDG-PET can be used to identify vulnerable plaques in atherosclerotic disease. Clinical FDG-PET camera systems are restricted in terms of resolution for the visualization of detailed inflammation patterns in smaller vascular structures. The aim of the study is to evaluate the possible added value of a high-resolution microPET system in excised carotid plaques using FDG. In this study, 17 patients with planned carotid endarterectomy were included. Excised plaques were incubated in FDG and subsequently imaged with microPET. Macrophage presence in plaques was evaluated semi-quantitatively by immunohistochemistry. Plaque calcification...
Marleen G. Masteling, Clark J. Zeebregts, Rene A. Tio, Jan-Cees Breek, Uwe J. F. Tietge, Jan Freark de Boer, Andor W. J. M. Glaudemans, Rudi A. J. O. Dierckx, Hendrikus H. Boersma, Riemer H. J. A. Slart