I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists.
Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
A Phase 1 study of RAD1901, an oral selective estrogen receptor degrader, in ER positive, HER2 negative, advanced breast cancer patients.
Published in: Journal of Clinical Oncology
Androgen receptor and estrogen receptor imaging in patients with metastatic breast cancer.
Published in: Journal of Clinical Oncology
Clasina Marieke Venema, Lemonitsa H. Mammatas, Michel van Kruchten, Giulia Apollonio,
Carolina Pia Schröder,
Andor W. J. M. Glaudemans, Otto S. Hoekstra, Henk M. W. Verheul,
Bert van der Vegt,
Erik F. J. De Vries,
Elisabeth G. E. de Vries, Catharina Wilhelmina Menke,
Geke Hospers
Imaging latent tuberculosis infection with radiolabeled nitroimidazoles
Published in: Clinical and Translational Imaging
Molecular imaging in ovarian cancer
Published in: Annals of Oncology
Ovarian cancer has a high mortality and novel-targeted treatment strategies have not resulted in breakthroughs for this disease. Insight into the molecular characteristics of ovarian tumors may improve diagnosis and selection of patients for treatment with targeted therapies. A potential way to achieve this is by means of molecular imaging. Generic tumor processes, such as glucose metabolism (F-18-fluorodeoxyglucose) and DNA synthesis (F-18-fluorodeoxythymidine), can be visualized non-invasively. More specific targets, such as hormone receptors, growth factor receptors, growth factors and targets of immunotherapy, can also be visualized. Molecular imaging...
PET/CT imaging of Mycobacterium tuberculosis infection.
Published in: Clinical and Translational Imaging
Tuberculosis has a high morbidity and mortality worldwide. Mycobacterium tuberculosis (Mtb) has a complex pathophysiology; it is an aerobic bacillus capable of surviving in anaerobic conditions in a latent state for a very long time before reactivation to active disease. In the latent tuberculosis infection, the individual has no clinical evidence of active disease, but exhibits a hypersensitive response to proteins of Mtb. Only some 5-10 % of latently infected individuals appear to have reactivation of tuberculosis at any one time point after infection, and neither imaging nor...
