Walter Noordzij
dr.
In my profession as a nuclear medicine physician, I’m involved in both clinical and scientific applications of nuclear medicine and radiology modalities. My main interests include haematology, general oncology, radio-immunotherapy, and especially the implementation of new therapeutic strategies. Currently, I have a special interest in imaging post-transplant lymphoproliferative disease, as well as radio-immunotherapy in chemotherapy refractory (non)-Hodgkin’s lymphoma.
Differential [18F]FAPI-42 and [18F]FDG uptake patterns distinguish desmoid tumours from GISTs on PET/CT imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Access to document
10.1007/s00259-025-07707-z
BACKGROUND: Intra-abdominal desmoid tumours (IADT) can closely mimic gastrointestinal stromal tumours (GISTs), particularly in recurrence and metastases. However, differentiating these two diseases using radiological methods remains challenging. This study aimed to investigate the value of [ 18F]FAPI-42 PET/CT in differentiating IADT and GISTs compared to [ 18F]FDG PET/CT. METHODS: This study retrospectively included a total of 24 patients (12 patients with IADT and 12 patients with recurrent/metastatic GISTs) who underwent two separate PET/CT scans using [ 18F]FAPI-42 and [ 18F]FDG, respectively. The differences in tumour SUV max on...
Chunhui Wu, Xiaoyan Wang, Xiaojie Lin, Andor W J M Glaudemans, Bart Cornelissen, Walter Noordzij, Xin Hu, Yu Zeng, Xiangsong Zhang, Xinhua Zhang
Separation of simultaneously acquired [89Zr]atezolizumab and [18F]FDG PET scans
Published in: European Journal of Nuclear Medicine and Molecular Imaging
Access to document
10.1007/s00259-025-07340-w
document
[18F]F-FAPI PET/CT and LAparoscopy in STagIng advanced gastric Cancer: a multicenter prospective study (PLASTIC-3 study).
Published in: BMC Cancer
Access to document
10.1186/s12885-025-15347-7
BACKGROUND: Treatment decisions for locally advanced gastric adenocarcinoma rely on staging with gastroscopy, computed tomography (CT), and staging laparoscopy (SL). However, CT often fails to detect peritoneal and other distant metastases, and SL is an invasive procedure with complication risks and costs. Therefore, an accurate non-invasive imaging biomarker to detect such metastases could improve the care for gastric cancer patients. Radiolabeled fibroblast-activating protein inhibitors (FAPI), targeting stromal cancer-associated fibroblasts, are promising radiotracers. Preliminary Asian studies indicate that FAPI PET/CT outperforms [ 18F]FDG PET/CT in tracer uptake, tumor-to-background ratio...
PLASTIC-3 Study Group, Lianne Triemstra, Sarah W J M Spruijt, Dennis Vriens, Erik Vegt, Wilma E Mesker, Luuk J A C Hawinkels, Sopany Saing, Marije Slingerland, Vera Kemp, Stijn A L P Crobach, Jelle J Goeman, Martin Pool, Petra Dibbets-Schneider, Roel J Bennink, Mark I van Berge Henegouwen, Marc J van Det, Boudewijn J van Etten, Henk H Hartgrink, Richard van HillegersbergMarnix G E H Lam, Nanda M Smulders, Misha D P Luyer, Walter Noordzij, Emilia C Owers, Wim J G Oyen, Johanna W van Sandick, Wendy Schreurs, Wobbe O de Steur, Jan H M B Stoot, Leo E Weijs, Bas P L Wijnhoven, Bart P L Witteman, Jelle P Ruurda, Lioe-Fee de Geus-Oei
Yttrium-90 Selective Internal Radiation Therapy for Neuroendocrine Liver Metastases: An Institutional Case Series, Updated Systematic Review, and Meta-Analysis
Published in: Diagnostics
Access to document
10.3390/diagnostics16010111
document
Background/Objectives: To evaluate the efficacy, safety, and symptom impact of yttrium-90 selective internal radiation therapy (Y-90 SIRT) for neuroendocrine liver metastases (NELM) through an updated systematic review and meta-analysis integrated with our institutional data. Methods: We retrospectively analyzed 12 patients with NELM treated with Y-90 resin microspheres between 2019 and 2024. Outcomes included overall survival (OS), hepatic progression-free survival (HPFS), symptom improvement, and adverse events. Concurrently, a systematic review and meta-analysis of 43 studies (including our institutional cohort; total n = 2221; 2008-2025) was conducted following PRISMA guidelines....
Xinlin Zheng, Fang Wen, Huan Xi, Joyce van Sluis, Reinoud P H Bokkers, Susanne Lütje, G Matthijs Kater, Frederik J H Hoogwater, Annemiek M E Walenkamp, Derk-Jan A de Groot, Simeon J S Ruiter, Walter Noordzij
Single-center experience comparing glass and resin microspheres in lobar Y-90 SIRT for early- to intermediate-stage hepatocellular carcinoma
Published in: EJNMMI Research
Access to document
10.1186/s13550-025-01343-2
document
BACKGROUND: Selective internal radiation therapy (SIRT) with yttrium-90 (Y-90) microspheres is an established locoregional treatment for early- to intermediate-stage hepatocellular carcinoma (HCC). While both resin and glass microspheres are widely used, their comparative effectiveness and safety in lobar infusion remain unclear. This study aimed to compare the effectiveness and safety of resin versus glass microspheres in patients with early- to intermediate-stage HCC undergoing lobar Y-90 SIRT. RESULTS: A retrospective single-center analysis was conducted on 37 consecutive patients with early- to intermediate-stage HCC who underwent lobar Y-90 SIRT (resin:...