PURPOSE: Yttrium-90 (90Y) selective internal radiation therapy (SIRT) is an established treatment for hepatocellular carcinoma (HCC), yet dose-response relationships remain incompletely understood. We evaluated whether voxel-based dose heterogeneity is associated with tumour response and treatment-related toxicity. METHODS: This retrospective study included 45 HCC patients with 68 lesions treated with 90Y resin SIRT. Dose distributions were derived from post-therapy 90Y PET/CT. DVH-based metrics included hot-spot (D2, D10, Dmax), cold-spot (D90, D98, Dmin), and coverage parameters (V100, V150, V200). Tumour response was assessed using mRECIST. Grade ≥ 3 toxicity was classified as...

Background: Prostate-specific membrane antigen (PSMA)-targeted radioguided surgery (PSMA-RGS) is a promising intraoperative technique for improving lesion localization and surgical accuracy in prostate cancer (PCa), particularly in high-risk or recurrent cases. Objective: To systematically evaluate the diagnostic performance of PSMA-RGS in PCa using multilevel meta-analysis. Methods: Following PRISMA 2020 guidelines, we searched PubMed, Embase, and Web of Science for clinical studies published between January 2016 and May 2025, with the final search performed on May 1, 2025, and identified 28 eligible studies. Diagnostic accuracy was assessed at the patient,...

PSMA PET/CT is increasingly used for prostate cancer staging, restaging, treatment selection, and therapy response assessment. In parallel, several interpretation frameworks have been developed to standardize reporting. PROMISE version 2 integrates the PRIMARY score for local disease, molecular imaging TNM staging, and a PSMA expression score. PSMA-RADS 2.0 supports lesion-level characterization, whereas response systems such as the PSMA PET progression criteria and RECIP 1.0 focus on treatment response assessment. Despite the availability of these systems and professional society guidance, real-world reporting remains heterogeneous, with limited framework adoption, inconsistent...

Objective – To investigate how often referring physicians perform history taking and physical examination before PET/computed tomography (PET/CT) referral, and whether their absence influences clinical reasoning quality or diagnostic yield.  Methods – Patients undergoing PET/CT at a tertiary academic hospital were asked whether their referring physician had conducted history taking and physical examination before referral. Associations between omission of clinical assessment and clinical reasoning quality or PET/CT positivity (defined as PET/CT findings relevant to the clinical indication) were analyzed using multivariable regression.  Results – Among 288 patients (median...