Lydia Visser
PhD
My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.
TIMP-I expression in anaplastic large cell lymphoma is usually restricted to macrophages and only seldom observed in tumour cells
Published in: The Journal of Pathology
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10.1002/path.1796
Anaplastic large cell lymphomas (ALCLs) can be subdivided into two subgroups on the basis of their expression of the ALK protein. ALK protein expression leads to activation of signal transducer and activator of transcription (STAT) 3, which is more commonly expressed in ALK-positive than in ALK-negative tumours. Activated STAT3 leads to the induction of several genes such as Mcl-1, Bcl-2 and Bcl-X-L, and tissue inhibitor of metalloproteinase (TIMP)-1. In this study, we analysed TIMP-1 expression in five ALCL cell lines and 11 tumours by quantitative RT-PCR and immunohistochemistry....
R Rust, T Blokzijl, G Harms, M Lim, L Visser, WA Kamps, S Poppema, Anke van den Berg
High expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma
Published in: Journal of Clinical Pathology
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10.1136/jcp.2004.022335
Aim: To gain more insight into the genes involved in the aetiology and pathogenesis of anaplastic large cell lymphoma (ALCL). Methods: Serial analysis of gene expression ( SAGE) was undertaken on the CD4+ALK+ ( anaplastic lymphoma kinase positive) ALCL derived cell line Karpas299 and as comparison on CD4+ T cells. Quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry were performed on five ALCL derived cell lines and 32 tissue samples to confirm the SAGE data. Results: High expression of Mcl-1 was seen in the Karpas299 cell line,...
R Rust, G Harms, T Blokzijl, M Boot, A Diepstra, J Kluiver, L Visser, SC Peh, M Lim, WA Kamps, S Poppema, Anke van den Berg
Dimeric galectin-1 induces IL-10 production in T-lymphocytes: an important tool in the regulation of the immune response
Published in: The Journal of Pathology
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10.1002/path.1671
J. Van der Leij, Anke van den Berg, T. Blokzijl, G. Harms, H. van Goor, Peter Zwiers, Robert van Weeghel, Sibrand Poppema, Lydia Visser
Prolonged survival of rat islet xenografts in mice after CD45RB monotherapy
Published in: Transplantation
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10.1097/01.TP.0000111741.85249.EC
Lydia Visser, Sibrand Poppema, Bart de Haan, Pieter Klok, J. Van der Leij, Anke van den Berg, P. de Vos
Shedding of L-selectin as induced by anti-CD45RB does not involve TACE/ADAM17
Downregulation of CD45RB and L-selectin by anti-CD45RB antibody treatment may play an important role in the mechanism of action these antibodies in transplantation and autoimmune animal models. We found that the metalloprotease TACE/ADAM17 is not involved. Therefore, anti-CD45RB may activate another protease to cause the shedding of L-selectin and possibly also CD45RB.
L Visser, S Poppema