Lydia Visser
PhD
My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.
Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes
Published in: Blood
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10.1182/blood-2007-09-112128
Hodgkin and Reed-Sternberg (HRS) cells in Hodgkin lymphoma (HL) secrete factors that interact with inflammatory background cells and may serve as biomarkers for disease activity. To detect new proteins related to pathogenesis, we analyzed the secretome of HRS cells. Proteins in cell culture supernatant of 4 HL cell lines were identified using 1 DGE followed by in-gel trypsin digestion and LC-MS/MS. In total, 1290 proteins, including 368 secreted proteins, were identified. Functional grouping of secreted proteins revealed 37 proteins involved in immune response. Sixteen of the 37 proteins...
Yue Ma, Lydia Visser, Johan Roelofsen, Marcel de Vries, Arjan Diepstra, Gustaaf van Imhoff, Tineke van der Wal, Marjan Luinge, Gloria Alvarez Llamas, Hans Vos, Sibrand Poppema, Roel Vonk, Anke van den Berg
HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBVI Hodgkin lymphoma
Published in: Blood
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10.1182/blood-2007-05-086934
Previous studies showed that the HLA class I region is associated with Epstein-Barr virus (EBV)-positive Hodgkin lymphoma (HL) and that HLA-A is the most likely candidate gene in this region. This suggests that antigenic presentation of EBV-derived peptides in the context of HLA-A is involved in the pathogenesis of EBV+ HL by precluding efficient immune responses. We genotyped exons 2 and 3, encoding the peptide-binding groove of HLA-A, for 32 single nucleotide polymorphisms in 70 patients with EBV+ HL, 31 patients with EBV- HL, and 59 control participants....
Marijke Niens, Ruth F. Jarreft, Bouke Hepkema, Ilja M. Nolte, Arjan Diepstra, Mathieu Platteel, Niels Kouprie, Craig P. Delury, Alice Gallagher, Lydia Visser, Sibrand Poppema, Gerard J. te Meerman, Anke Van den Berg
Hodgkin’s lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments
Background: Hodgkin’s lymphoma (HL) is characterised by an ineffective immune response that is predominantly mediated by CD4(+) T-cells. Aims: To analyse the expression of the key regulatory T-cell transcription factors (TFs) in the T-cells of HL involved tissues in order to assess the nature of the T-H immune response in HL. Methods and results: By immunohistochemistry, GATA3 was strongly and T-bet exclusively expressed in a subset of interfollicular lymphocytes in the reactive lymphoid tissues. In classical HL (CHL), which is generally located in the interfollicular zones, a predominance...
Cigdem Atayar, Anke van den Berg, Tjasso Blokzijl, Marcel Boot, Randy D. Gascoyne, Lydia Visser, Sibrand Poppema
5 ‘-UTR FAS mutation pattern and frequency in nodal diffuse large B-cell lymphoma similar to normal germinal center B cells
Published in: Leukemia and Lymphoma
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10.1080/10428190701297378
Anke Van den Berg, Lydia Visser, Sibrand Poppema
Strongly enhanced IL-10 production using stable galectin-1 homodimers
Published in: Molecular Immunology
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10.1016/j.molimm.2006.02.011
Galectin-1 is the homodimeric form of a protein, which is present in a dynamic equilibrium with the beta-galactoside monomeric form and has potent anti-inflammatory and immunomodulating effects. These favorable effects are probably related to the induction of apoptosis in activated T cells and the induction of IL-10, which have been demonstrated to be characteristic for the dimeric form of the protein. Based on these findings it can be speculated that the in vivo effects of galectin-1 can be improved by the generation of stable galectin-1 homodimers (dGal). To...
Judith van der Leij, Anke van den Berg, Geert Harms, Hugo Eschbach, Hans Vos, Peter Zwiers, Rob van Weeghel, Herman Groen, Sibrand Poppema, Lydia Visser