Lydia Visser
PhD
My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.
Supplementary Material for: MicroRNA High Throughput Loss-of-Function Screening Reveals an Oncogenic Role for miR-21-5p in Hodgkin Lymphoma
Access to document
10.6084/m9.figshare.7047695
Background/Aims: Classical Hodgkin lymphoma (cHL) is among the most frequent lymphoma subtypes. The tumor cells originate from crippled germinal center (GC)-B cells that escaped from apoptosis. MicroRNAs (miRNAs) play important roles in B-cell maturation and aberrant expression of miRNAs contributes to the pathogenesis of cHL. Our aim was to identify oncogenic miRNAs relevant for growth of cHL using a high-throughput screening approach. Methods: A lentiviral pool of 63 miRNA inhibition constructs was used to identify miRNAs essential to cell growth in three cHL cell lines in duplicate. As...
Ye Yuan (Creator)Fubiao Niu (Creator)Ilja Nolte (Creator)Jasper Koerts (Creator)Bea Rutgers (Creator)Jan Osinga (Creator)Maria Sarkis Azkanaz (Creator)Martijn Terpstra (Creator)Leo Bystrykh (Creator)Arjan Diepstra (Creator)Lydia Visser (Creator)Agnieszka Dzikiewicz-Krawczyk (Polish Academy of Sciences) (Creator)Klaas Kok (Creator)Joost Kluiver (Creator)Anke van den Berg (Creator)
Supplementary Material for: MicroRNA High Throughput Loss-of-Function Screening Reveals an Oncogenic Role for miR-21-5p in Hodgkin Lymphoma
Access to document
10.6084/m9.figshare.7047695.v1
Background/Aims: Classical Hodgkin lymphoma (cHL) is among the most frequent lymphoma subtypes. The tumor cells originate from crippled germinal center (GC)-B cells that escaped from apoptosis. MicroRNAs (miRNAs) play important roles in B-cell maturation and aberrant expression of miRNAs contributes to the pathogenesis of cHL. Our aim was to identify oncogenic miRNAs relevant for growth of cHL using a high-throughput screening approach. Methods: A lentiviral pool of 63 miRNA inhibition constructs was used to identify miRNAs essential to cell growth in three cHL cell lines in duplicate. As...
Fubiao Niu (Contributor)Ye Yuan (Second Affiliated Hospital of Harbin Medical University) (Contributor)Maria Sarkis Azkanaz (Contributor)Arjan Diepstra (Contributor)Leo Bystrykh (Contributor)Lydia Visser (Contributor)Agnieszka Dzikiewicz-Krawczyk (Polish Academy of Sciences) (Contributor)Jan Osinga (Contributor)Bea Rutgers (Contributor)Klaas Kok (Contributor)Jasper Koerts (Contributor)Martijn Terpstra (Contributor)Joost Kluiver (Contributor)Anke van den Berg (Contributor)Ilja Nolte (Contributor)Debora de Jong (Contributor)