Joost Kluiver
dr.
I have a central role in all research projects focusing on the role of noncoding RNAs. My main aim is to understanding how small and long non-coding RNAs contribute to the pathogenesis of B-cell lymphoma. Ongoing studies include MYC-regulated miRNAs and lncRNAs, as well as miRNA-lncRNA interactions and the role of circular RNAs. We apply state-of-the-art methodology including AGO2-RIP, RNA-FISH and gain- and loss-of-function screens using shRNA and CRISPR-Cas technology.
Latest publications
(104)
Activities
(80)
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(2)
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(2)
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(4)
Supervised work
(17)
Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis
Published in: Cancers
Access to document
10.3390/cancers16061126
document
Classical Hodgkin lymphoma (cHL) is a hematological malignancy of B-cell origin. The tumor cells in cHL are referred to as Hodgkin and Reed-Sternberg (HRS) cells. This review provides an overview of the currently known miRNA-target gene interactions. In addition, we pinpointed other potential regulatory roles of microRNAs (miRNAs) by focusing on genes related to processes relevant for cHL pathogenesis, i.e., loss of B-cell phenotypes, immune evasion, and growth support. A cHL-specific miRNA signature was generated based on the available profiling studies. The interactions relevant for cHL were extracted...
UNMASK
In collaboration with Games for health Europe we designed a citizen science game to let the gernal public help us with the identification of miRNA targets for important lymphoma associated miRNAs. See UNMASK.NL
Joost Kluiver (Photographer), A. van den Berg (Photographer)
Analysis of primary miRNA processing in normal and malignant B-cells
I. Slezak-Prochazka, K. Kok, P. Bil, J. Kluiver, A. van den Berg
Studying the role of oncogenic mir-24-3p in hodgkin lymphom
Y. Yuan, J. Kluiver, J. Koerts, D. de Jong, Bea Rutgers, A. Diepstra, Lydia Visser, Anke Berg, van den
Mutations in CD58 and MYB in Hodgkin Lymphoma
F.R. Abdul Razak, A. Diepstra, D. Jong, J. Koerts, B. Rutgers, J. Kluiver, Lydia Visser, Anke Berg, van den